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Molecular epidemiology on two new human malaria in Southeast Asia

Research Project

Project/Area Number 13576006
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 寄生虫学(含医用動物学)
Research InstitutionNagoya University

Principal Investigator

KAWAMOTO Fumihiko  Nagoya University, Graduate School of Medicine Assoc.Prof., 大学院・医学系研究科, 助教授 (40115556)

Co-Investigator(Kenkyū-buntansha) KIMURA Masatsugu  Osaka City University, Med.Sch.Assoc.Prof, 大学院・医学研究科, 助教授 (60195378)
KONDO Takaaki  Nagoya University, Graduate School of Medicine Assoc. Prof, 大学院・医学系研究科, 助教授 (00195900)
MATSUOKA Hiroyuki  Jichi Medical School, Med.Sch.Assoc.Prof., 医学部, 助教授 (10173816)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2002: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2001: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsinternational collaboration / Plasmodium malariae / Plasmodium ovale / malaria / gene analysis / SSUrRNA gene / field survey / Myaynmar : Indonesia : Vietnam : Thailand / 新型卵型マラリア原虫 / 野外調査 / ミャンマー:インドネシア:タイ / 分子疫学的調査 / ミャンマー:インドネシア:ベトナム
Research Abstract

During 2001 to 2002, field surveys of malaria were conducted in Southeast Asia, including Myanmar, Indonesia, Vietnam and Thailand, by using a rapid diagnosis with acridine orange staining, and gene analysis was performed on Plasmodium malariae and P.ovale isolates.
1. In Myanmar, malaria surveys were conducted at many villages in Sagain Division, Rakhine State, Mon State, Mandalay Division, Shan State and Tanintharyi Division during 2001 to 2002. In all villages, we detected many patients infected with the new types of P.malariae and several patients infected with P.ovale. In addition, single infections with the new types of P.malariae and P.ovale were also detected from many villages.
2. In Indonesia, we surveyed malaria at Maumere and Lalantuka, Flores island, East Nusa Tenggara Province, during 2001 to 2002. At both places, many patients infected with P.malariae and some patients infected with P.ovale were detected.
3. In Vietnam, malaria survey was done at Bao Loc, Lam Dong Province, on September 2001, but the new types of P.malariae and P.ovale were not found.
4. In Thailand, malaria surveys were performed at Sangkhlaburi on November, 2002, and three cases infected with the new types of P.malariae were detected. But, P.ovale infection was not detected.
5. The SSUrRNA gene was analyzed in all wild isolates of P.malariae and P.ovale collected from Southeast Asia, and all, except for one P.ovale isolate, were reconfirmed as the new variant types. In addition, single infections with the new types of P.malariae were also reconfirmed by molecular diagnosis.
6. Analysis of the full SSUrRNA gene in variant P.ovale isolates collected from Southeast Asia indicated that they were actually the new type.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] A.Laoboonchai et al.: "PCR-based ELISA technique for malaria diagnosis of specimens from Thailand"Trop.Med.Int. Health. 6・6. 458-462 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C.Wongsrichanalai et al.: "In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs."Am.J.Trop.Med. Hyg. 65・5. 450-455 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.T.Win et al.: "Detection of Plasmodium ovale by the ICT Malaria P.f/P.v. immunochromatographioc test"Acta Tropica. 80・3. 283-284 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] D.P.Mason et al.: "A comparison of two rapid field immuno chromatographic tests to expert microscopy in the diagnosis of malaria"Acta Tropica. 82・1. 51-59 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.T.Win et al.: "Wide distribution of Plasmodium ovale in Myanmar"Trop.Med.Int. Health. 7・3. 231-239 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F.Kawamoto et al.: "Unusual Plasmodium malariae-like parasites in Southeast Asia"J.Parasitology. 88・2. 350-357 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A.Laoboonchai et al.: "PCR-based ELISA technique for malaria diagnosis of specimens from Thailand"Trop.Med.Int.Health. 6. 458-462 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] C.Wongsrichanalai et al.: "In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs"Am.J.Trop.Med.Hyg. 65. 450-455 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.T.Win et al.: "Detection of Plasmodium ovale by the ICT Malaria P.f/P.v.immunochromatographioc test"Acta Tropica. 80. 283-284 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] D.P.Mason et al.: "A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria"Acta Tropica. 82. 51-59 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.T.Win et al.: "Wide distribution of Plasmodium ovale in Myanmar"Trop.Med.Int.Health. 7. 231-239 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] F.Kawamoto et al.: "Unusual Plasmodium malariae-like parasites in Southeast Asia"J.Parasitology. 88. 350-357 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] D.P.Mason et al.: "A comparison of two rapid field immuno chromatographic tests to expert microscopy in the diagnosis of malaria"Acta Tropica. 82・1. 51-59 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.T.Win et al.: "Wide distribution of Plasmodium ovale in Myanmar"Trop. Med. Int. Health. 7・3. 231-239 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Unusual Plasmodium malariae-like parasites in Southeast Asia"J. Parasitology. 88・2. 350-357 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] A.Laoboonchai et al.: "PCR-based ELISA technique for malaria diagnosis of specimens from Thailand."Trop.Med.Int.Health. 6・6. 458-462 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.Wongsrichanalai et al.: "In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs."Am.J.Trop.Med.Hyg.. 65・5. 450-455 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.T.Win et al.: "Detection of Plasmodium ovale by the ICT Malaria P.f/P.v.immunochromatographic test."Acta Tropica. 80・3. 283-284 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] D.P.Mason et al.: "A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria."Acta Tropica. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.T.Win et al.: "Wide distribution of Plasmodium ovale in Myanmar."Trop.Med.Int.Health. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Unusual Plasmodium malariae-like parasites in Southeast Asia."J.Parasitol.. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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