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Molecular Epidemiological Study on Human Hereditary Resistant Factors to Malaria

Research Project

Project/Area Number 13576017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionKobe University

Principal Investigator

SHIRAKAWA Taku  Kobe University, School of Medicine, Associate professor, 医学部, 助教授 (30171044)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Shigeru  Osaka University, Graduate School of Literature, Professor, 大学院・文学研究科, 教授 (30087150)
MATSUO Masafumi  Kobe University, Graduate School of Medicine, professor, 大学院・医学系研究科, 教授 (10157266)
NISHIYAMA Kaoru  Kobe University, School of Medicine, professor, 医学部, 教授 (00150061)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥9,300,000 (Direct Cost: ¥9,300,000)
KeywordsMalaria / G6PD Deficiency / α-Thalassemia / Southeast Asian Ovalocytosis / Hemoglobin Abnormality / Gene Analysis / G6PD
Research Abstract

Inherited erythrocyte disorders related to malaria resistance were investigated in some Asian countries.
We analyzed one hundred twenty two samples of the G6PD deficiency with neonatal jaundice in Singapore by MPTP and direct sequencing method. As the result, the mutations in the exon of G6PD gene were identified in 111 of the samples. By contrast, in other 11 samples, such mutations were not identified in the exon, nor in the promoter region.
In Malaysia, G6PD deficiency and SAO were investigated with 300 cord blood samples and the frequency were 3.3% and 4.8%, respectively. Sixty-five patients out of 141 neonatal jaundice patients were diagnosed as G6PD deficiency. Incidence of SAO in patients with distal renal tubular acidosis (dRTA) was significantly higher (81.8%) compared with normal adults (4%). These results indicate that these disorders become to the health problem in Malaysia.
G6PD deficiency, ovalocytosisi, α-thalassemia and β-globin gene abnormality were investigated with cord and peripheral blood samples in 3 different places in Nepal. Kathmandu valley located on the altitude of 1400m is a low malaria endemic area in Nepal. The frequency of α-thalassemia was 20 % and that of other factors were very low in Kathmandu. Japha located on southeast Nepal is a middle malaria endemic area. The frequency of α-thalassemia was 15 % in this area. The majority such as Brahmin, Chhetri, Newar and Mongolian in Nepal live in Kathmandu and Jhapa. On the other hand, Danuwar, a minority in Nepal, living in high malaria endemic area had high prevalence of α-thalassemia (75%) and G6PD deficiency (3.1%). These results suggest that α-thalassemia adapt Danuwar to malaria infection, whereas almost majority in Nepal have little resistant factors to malaria.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Yusoff NM, et al.: "High prevalence of Southeast Asian ovalocytosis in Malays with distal renal tubular acidosis."Journal of Human Genetics. 48・12. 650-653 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Watanabe K, et al.: "Bancroftian filariasis in Nepal : a survey for circulating antigenemia of Wuchereria bancrofti and urinary IgG4 antibody in two rural areas of Nepal."Acta Tropica. 88・1. 11-15 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Padilla C, et al.: "Screening for glucose-6-phosphate dehydrogenase deficiency using a modified formazan method : a pilot study on Filipino male newborns."Pediatric International. 45・1. 10-15 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yusoff NM, et al.: "Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Malays in Malaysia."International Journal of Hematology. 76・2. 149-152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Narazah M, Yusoff et al.: "Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Malays in Malaysia."International Journal of Hematology. 76-2. 149-152 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Carmencita, Padilla et al.: "Screening for glucose-6-phosphate dehydrogenase deficiency using a modified formazan method : a pilot study on Filipino male newborns."Pediatric International. 45-1. 10-15 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Narazah M, Yusoff et al.: "High prevalence of Southeast Asian ovalocytosis in Malays with distal renal tubular acidosis."Journal of Human Genetics. 48-12. 650-653 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kanji, Watanabe: "Bancroftian filariasis in Nepal : a survey for circulating antigenemia of Wuchereria bancrofti and urinary IgG4 antibody in two rural areas of Nepal."Acta Tropica. 88-1. 11-15 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yusoff NM, et al.: "High prevalence of Southeast Asian ovalocytosis in Malays with distal renal tubular acidosis"Journal of Human Genetics. 48・12. 650-653 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Watanabe K, et al.: "Bancroftian filariasis in Nepal : a survey for circulating antigenemia of Wuchereria bancrofti and urinary IgG4 antibody in two rural areas of Nepal"Acta Tropica. 88・1. 11-15 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Padilla C, et al.: "Screening for glucose-6-phosphate dehydrogenase deficiency using modified formazan method : a pilot study on Filipino male newborns"Pediatric International. 45・1. 10-15 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yusoff NM, et al.: "Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Malays in Malaysia"International Journal of Hematology. 76・2. 149-152 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Narazah Mohd Yusoff, et al.: "Molecular Heterogeneity of Glucose-6-Phosphate Dehydrogenase Deficiency in Malays in Malaysia"International Journal of Hematology. 76・2. 149-152 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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