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Polymorphism in cancer-related genes among oral cancers from the eastern Asian area

Research Project

Project/Area Number 13576025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

CHENG Jun  Niigata University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (40207460)

Co-Investigator(Kenkyū-buntansha) OHSHIRO Kazufumi  Niigata University, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (50332648)
SUZUKI Makoto  Niigata University, Medical and Dental Hospital, Lecture, 医歯学総合病院, 講師 (50107778)
SAKU Takashi  Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (40145264)
MIYAZAKI Hideo  Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (00157629)
IDA Hiroko  Niigata University, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (60293213)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2003: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsAsia nation / oral cancer / superficial squamous cell carcinoma / pre-cancer / dysplasia / orthoprosthesis / chew tobacco / pathologic epidemiology / アポトーシス / 噛みたばこ / 口腔癌 / 癌関連遺伝子 / リンパ球 / 表在癌 / マイクロディセクション / PCR / 東アジア / 南アジア
Research Abstract

Oral cancers and precancerous lesions were collected from China, Sri-Lanka, Bangladesh, and India. Among the present collection of oral cancers and precancerous lesions, we found lesions which can be referred to as superficial carcinoma in many areas with or without the custom of chewing tobacco. There were 128 cases of superficial carcinoma among 800 cases of oral squamous cell carcinoma. Among them, 82 superficial carcinomas out of 680 cases from the Japanese population. The clinicopathobgical characteristics of the Japanese patients with superficial carcinoma were as follows : the patients were mainly older women ; the superficial carcinoma arose more commonly in the longue, gingival, and buccal mucosa ; the Lesions were multiple and recurrent ; less consumptions of tobacco for smoking and alcohol than patients with invasive carcinomas ; the superficial carcinoma lesions had some association with the patients' anamneses for prosthetic treatments. In contrast, the lesion from Asian c … More ountries was found exclusively in the buccal mucosa and gingival, and the patients were mainly males with chewing habits. Histopathobgy of the superficial carcinoma was the same among the Japanese and Asian patients. They were commonly composed of carcinoma in-situ, which could be divided into three types, such as basaloid, verrucous, and acanthotic, and of surrounding epithelial dysplasia with the characteristic two-phase appearances. In order to recognize such a disease entity of superficial carcinoma of the oral mucosa, a workshop was taken place in Singapore in August 2002, at which oral pathologists from Japan, Korea, Malaysia, Indonesia, Sri-Lanka, and the United Kingdom attended and discussed about the possibility of the concept
Using paraffin-embedded specimens collected from Asian countries, superficial carcinomas were investigated in several aspects as follows : the characteristic two-phase appearance in epithelial dysplasia was investigated by immunohistochemistry and in-situ hybridization, and its molecular mechanism was revealed to be due to apoptosis of prickle cells by mechanical stress of basaloid cell proliferation in the lower layer and thick keratinization in the surface layer. In addition, extracellular matrix remodeling in oral submucous fibrosis was determined for one of the backgrounds of oral carcinogenesis. DNA samples obtained by microdissection were analyzed for mutational events in cancer-related genes. Among them, there were several characteristic mutations in the p53 gene which were shared by the collected cases.
Based on the data obtained in this study, it is highly suggested that superficial carcinomas of the oral mucosa caused by different environmental factors shared similar genetic alterations in the cancer-related genes. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (48 results)

All 2005 2004 2003 2002 Other

All Journal Article (34 results) Publications (14 results)

  • [Journal Article] Extracellular matrix remodeling in oral submucous fibrosis : its stage-specific modes revealed by immunohistochemistry and in-situ hybridization2005

    • Author(s)
      Utsunomiya H
    • Journal Title

      J Oral Pathol Med (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas2005

    • Author(s)
      Jen KY
    • Journal Title

      Virus Genes 30(2)

      Pages: 223-235

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells2005

    • Author(s)
      Syafriadi M
    • Journal Title

      J Oral Pathol Med 34(3)

      Pages: 140-149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Extracellular matrix remodeling in oral submiicous fibrosis : its stage-specific modes revealed by immunohistochemistry and in-situ hybridization2005

    • Author(s)
      Utsunomiya H, Tilakaratne WM, Ohshiro K, Ida-Yonemochi H, Cheng J, Saku T
    • Journal Title

      Journal of Oral Pathology & Medicine 2005 (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas2005

    • Author(s)
      Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, Lin HL, Chen Z, Gurtsevitch V, Fujii M, Saku T
    • Journal Title

      Virus Genes 30(2)

      Pages: 223-235

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells2005

    • Author(s)
      Syafriadi M, Cheng J, Jen KY, Ida-Yonemochi H, Suzuki M, Saku T
    • Journal Title

      Journal of Oral Pathology & Medicine 34(3)

      Pages: 140-149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Superficial carcinoma of the oral mucosa : a new disease entity caused by prosthetic treatments2004

    • Author(s)
      Cheng J
    • Journal Title

      Cancer Science 95(S)

      Pages: 535-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Histopathological criteria for carcinoma in-situ of the oral mucosa confirmed by p53 gene mutation2004

    • Author(s)
      Syafriadi M
    • Journal Title

      日本病理学会会誌 93(1)

      Pages: 339-339

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium2004

    • Author(s)
      Ikarashi T
    • Journal Title

      J Oral Pathol Med 33(2)

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 基底膜型ヘパラン硫酸プロテオグリカン・パールカンの上皮内配置:上皮内間質という新しい概念2004

    • Author(s)
      依田 浩子
    • Journal Title

      Niigata Dent J 34(2)

      Pages: 83-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Differential expression of extracellular matrix molecules in co-culture of squamous cell carcinoma cells and fibroblasts2004

    • Author(s)
      Metwaly H
    • Journal Title

      J Oral Pathol Med 33(8)

      Pages: 510-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Superficial carcinoma of the oral mucosa : a new disease entity caused by prosthetic treatments2004

    • Author(s)
      Cheng J, Suzuki M, Maruyama S, Saku T
    • Journal Title

      Cancer Science 95(S)

      Pages: 535-535

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Histopathological criteria for carcinoma in-situ of the oral mucosa confirmed by p53 gene mutation2004

    • Author(s)
      Syafriadi M, Cheng J, Suzuki M, Jen KY, Saku T
    • Journal Title

      Journal of the Japanese Society of Pathology 93(1)

      Pages: 339-339

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium2004

    • Author(s)
      Ikarashi T, Ida-Yonemochi H, Ohshiro K, Cheng J, Saku
    • Journal Title

      Journal of Oral Pathology & Medicine 33(2)

      Pages: 87-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Perlecan, a basement membrane type heparan sulfate proteoglycan, in the epithelial space : a possibility of a new concept of intraepithelial stroma2004

    • Author(s)
      Ida H, Saku T
    • Journal Title

      Niigata Dental Journal 34(2)

      Pages: 83-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Differential expression of extracellular matrix molecules in co-culture of squamous cell carcinoma cells and fibroblasts2004

    • Author(s)
      Metwaly, H, Cheng J, Saku T
    • Journal Title

      Journal of Oral Pathology & Medicine 33(8)

      Pages: 510-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Carcinoma in-situ of the oral mucosa has a definite tendency towards keratinization2003

    • Author(s)
      Syafriadi M
    • Journal Title

      Oral Med Pathol 8(2)

      Pages: 43-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas2003

    • Author(s)
      Jen KY
    • Journal Title

      Int J Cancer 105(5)

      Pages: 654-660

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Jaw bone remodeling at the invasion front of gingival squamous cell carcinomas2003

    • Author(s)
      Ito M
    • Journal Title

      J Oral Pathol Med 32(1)

      Pages: 10-17

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Clinicopathological characteristics of superficial carcinoma of the oral mucosa : prosthodontic anamneses as its pathogenetic factor2003

    • Author(s)
      Cheng J
    • Journal Title

      Cancer Science 94(S)

      Pages: 459-460

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization for ECM molecules of two distinct types of the neoplastic stroma in oral SCC2003

    • Author(s)
      Jen KY
    • Journal Title

      日本病理学会会誌 92(1)

      Pages: 361-361

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Carcinoma in-situ of the oral mucosa has a definite tendency towards keratinization2003

    • Author(s)
      Syafriadi M, Ida-Yonemochi H, Ikarashi T, Maruyama S, Jen KY, Cheng J, Hoshina h, Takagi R, Saku T
    • Journal Title

      Oral Medicine and pathology 8(2)

      Pages: 43-44

    • NAID

      110006792246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas2003

    • Author(s)
      Jen KY, Cheng J, Li J, Wu L, Li Y, Yu S, Lin H, Chen Z, Gurtsevitch V, Saku T
    • Journal Title

      International Journal of Cancer 105(5)

      Pages: 654-660

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Jaw bone remodeling at the invasion front of gingival squamous cell carcinomas2003

    • Author(s)
      Ito M, Izumi N, Cheng J, Sakai H, Nakajima T, Oda K, Saku T
    • Journal Title

      Journal of Oral Pathology & Medicine 32(1)

      Pages: 10-17

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Clinicopathological characteristics of superficial carcinoma of the oral mucosa : prosthodontic anamneses as its pathogenetic factor2003

    • Author(s)
      Cheng J, Suzuki M, Saku T
    • Journal Title

      Cancer Science 94(S)

      Pages: 459-460

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Characterization for ECM molecules of two distinct types of the neoplastic stroma in oral SCC2003

    • Author(s)
      Jen KY, Cheng J, Ohshiro K, Ida H, Ikarashi T, Saku T
    • Journal Title

      Proceedings of The Japanese Society of Pathology 92(1)

      Pages: 361-361

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 口腔粘膜扁平上皮癌とその境界病変:組織学的評価に関する新しい動向とその病理学的背景2002

    • Author(s)
      朔 敬
    • Journal Title

      Niigata Dent J 32(2)

      Pages: 209-224

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 口腔粘膜表在癌:新しい疾患概念2002

    • Author(s)
      東 良平
    • Journal Title

      Niigata Dent J 32(1)

      Pages: 91-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Apoptosis is the reason for characteristic two-phase appearance of oral mucosal epithelial dysplasia2002

    • Author(s)
      Syafriadi M
    • Journal Title

      歯科基礎医学会雑誌 44(5)

      Pages: 184-184

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 粘膜下線維症の進行と細胞外基質分子の動態2002

    • Author(s)
      宇都宮宏子
    • Journal Title

      歯科基礎医学会雑誌 44(5)

      Pages: 167-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] New concepts in histopathologic evaluation of squamous cell carcinoma and its borderline lesions of the oral mucosa2002

    • Author(s)
      Saku T
    • Journal Title

      Niigata Dental Journal 32(2)

      Pages: 209-224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Superficial carcinoma of the oral mucosa : a new disease entity2002

    • Author(s)
      Azuma R, Syafriadi M, Suzuki M, Ida H, Cheng J, Saku T
    • Journal Title

      Niigata Dental Journal 32(1)

      Pages: 91-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Apoptosis is the reason for characteristic two-phase appearance of oral mucosal epithelial dysplasia2002

    • Author(s)
      Syafriadi M, Cheng J, Ida H, Saku T
    • Journal Title

      Journal of Oral Biosciences 44(5)

      Pages: 184-184

    • NAID

      110003165023

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Extracellular matrix molecules in oral submucous fibrosis2002

    • Author(s)
      Utsunomiya H, Cheng J, Ohshiro K, Tilakaratne WM, Saku T
    • Journal Title

      Journal of Oral Biosciences 44(5)

      Pages: 167-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Cheng J: "Clinicaopathological characteristics of superficial carcinoma of the oral mucosa : prosthodontic anamneses as its pathogenetic factor"Cancer Science. 94(S). 459 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikarashi T: "Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium"J Oral Pathol Med. 33(2). 87-95 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Syafriadi M: "Carcinoma in-situ of the oral mucosa has a definite tendency towards keratinization"Oral Med Pathol. 8(2). 43-44 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Jen KY: "Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas"Int J Cancer. 105(5). 654-660 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nagata M: "Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis"Int J Cancer. 106(5). 683-689 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Jen K Y: "Mutational events in LMP gene of Epstein-Barr virus in salivary gland lymphepithelial carcinomas"Int J Cancer. 105(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Cheng J: "Epstein-Barr virus infected lymphepithelial carcinomas of the salivary gland in the Russia-Asian area : a clinicopathologic study of 160 cases"Archivs of Pathology. 47(1). 45-50 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ito M: "Jaw bone remordeling at the invasion front of gingival squamous cell carcinomas"J Oral Pathol Med. 32(1). 10-17 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 朔 敬: "口腔粘膜扁平上皮癌とその境界病変:組織学的評価に関する新しい動向と其の病理学的背景"新潟歯学会雑誌. 32(2). 209-224 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mei Syafriadi: "Carcinoma in-situ of the oral mucosa has a definite tendency for keratinization"Oral Medicine & Pathology. 8(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 東 良平: "口腔粘膜表在癌:新しい疾患概念"新潟歯学会雑誌. 32(1). 91-92 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 鈴木 誠 ほか: "舌癌-長期にわたり再発をくりかえした口腔癌の一例-"新潟医学会雑誌. 31(2). 61-64 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Jen K., et al.: "Stromal characteristics of squamous cell carcinoma of the tongue compared between well- and poorly-differentiated foci : an immunohistochemical study"歯科基礎医学会雑誌. 43(5). 632 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 鈴木 誠 ほか: "口腔粘膜多発癌の臨床病理学的検討"日本病理学会雑誌. 91(1). 342 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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