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Molecular etiological study on buccal carcinogenesis in Bangladesh

Research Project

Project/Area Number 13576026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionHokkaido University

Principal Investigator

YASUDA Motoaki  Hokkaido University, Hokkaido University, Graduate shool of Dentai medicine, assisant professor (90239765)

Co-Investigator(Kenkyū-buntansha) HIGASHINO Fumibito  Hokkaido university, Guaduate school of Dental medicine, lecture (50301891)
SHINDOH Masanobu  Hokkaido university, Guaduate school of Dental medicine, assisant professor (20162802)
千葉 逸朗  北海道大学, 大学院・歯学研究科, 講師 (50250460)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2001: ¥8,200,000 (Direct Cost: ¥8,200,000)
KeywordsHPV / DNA array / Baccal cancer / Bangladesh / ヒトパピローマウイルス / バングラデッシュ / メンブレンアレイ / 口腔がん / 分子疫学
Research Abstract

The prevalence of human papillomavirus (HPV) in healthy and pathological oral tissue samples collected in Bangladesh and Japan was analyzed. PCR amplification with a consensus primer set (1) and a novel DNA array system detecting twenty-five different HPV genotypes were utilized. PCR amplification was able to detect one copy of HPV plasmid. The DNA array system used in this study could detect fifty copies of HPV plasmid without cross hybridization. HPV was found in 2 of the 28 Japanese samples but not in any of the 55 normal mucosa or 21 cancer samples from Bangladesh. These results together with results of a previous study on prevalence of HPV in Japanese oral cancers (detection of HPV genome in 25% of oral cancer samples ; (2)) suggest that a geometrical difference in HPV infection exists, and that HPV plays an insignificant role in the carcinogenesis of buccal mucosae in Bangladesh. It is possible that differences in life styles contribute to the discrepancy in HPV detection rate. However, the mechanism of HPV transmission to the oral region is still obscure.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (4 results)

All 2005 2003

All Journal Article (4 results)

  • [Journal Article] Comprehensive Detection of Human Papillomavirus in Buccal Cancer2005

    • Author(s)
      Hamahira S., et al.
    • Journal Title

      Dentistry in Japan 41(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Comprehensive Detection of Human Papillomavirus in Buccal Cancer2005

    • Author(s)
      Hamahira S, et al.
    • Journal Title

      Dentistry in Japan vol.41(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] 口腔粘膜におけるヒトパピローマウイルス感染とウイルスゲノムの網羅的検出法2003

    • Author(s)
      安田元昭
    • Journal Title

      ウイルス感染症セミナー 第5号

      Pages: 13-18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] The comprehensive detection system for human papillomavirus.2003

    • Author(s)
      Yasuda M
    • Journal Title

      Seminar of virus infection Vol.5

      Pages: 14-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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