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Mechanism of Isotopic Fractionation of Transition Metals through Organic-Inorganic Interactions

Research Project

Project/Area Number 13640489
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 地球化学
Research InstitutionTOKYO INSTITUTE OF TECHNOLOGY

Principal Investigator

HIRATA Takafumi  Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Associate Professor, 大学院・理工学研究科, 助教授 (10251612)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsFe and Zn isotopes / Red Blood Cell / ICP-Mass Spectrometry / Biologically Induced Isotopic Fractionation / External Correction / Metals in Biochemical Samples / 生体試料中の金属 / 鉄同位体 / 亜鉛同位体 / 溶媒抽出法 / 遷移金属 / 銅同位体分別 / 亜鉛同位体分別 / 鉄同位体分別 / 無機的反応 / プラズマイオン源質量分析法 / 生物誘起起源鉄鉱床 / Goethite
Research Abstract

The study of natural isotopic variations for heavier elements (e. g. , Fe, Cu, Zn or Ge) had a significant influence in many research fields such as biology, planetary, Earth, and environmental sciences. Recent series of isotopic study for transition metals revealed that the isotopic compositions of Fe and Zn were largely fractionated through biologically induced processes. This indicates that isotopic ratios of heavy elements can be used as a new biomarker for geological samples (Isotopic Biomarker). However, the mechanisms of large isotopic fractionation of heavy elements were still unclear. In order to understand the mechanism of large isotopic fractionation of heavy elements, and also to discuss the genetic link between the large isotopic fractionation and biological processes, further precise and reliable isotopic data must be obtained from series of biochemical samples.
Detection of natural variation in isotopic composition of the heavy elements was very difficult because of their … More small magnitude of isotopic fractionation mainly due to small relative mass differences. To overcome this, sensitive and precise isotopic ratio measurements for heavy elements, especially for transition metals, have been made by means of a multiplecollector-ICP-Mass Spectrometry (MC-ICPMS). The precision and repeatability of the isotopic ratio measurements can be remarkably improved by a combination of sample-standard bracketing technique and newly developed correction for slow response of the Faraday preamplifiers. The precision and reliability of the resulted Fe and Zn isotopic ratio data were comparable to the isotopic data obtained by a thermal ionisation-mass spectrometry (TIMS). It should be noted that total amount of Zn and Fe required for the ICPMS measurements were almost order of magnitude lower than those for TIMS technique. This indicates that the ICPMS technique becomes now standard technique for sensitive and rapid isotopic ratio measurements for most transition metals.
The isotopic ratios of Fe and Zn in human blood cell (BRC) samples were measured. No significant seasonal change could be found both for Fe and Zn obtained from series of 12-month RBC samples. This can be explained by a small exchange efficiency (1 mg per day) of these elements in human body. The Fe isotopes in the RBC samples were largely fractionated (~1.5‰/amu), whereas Zn isotopes in the RBC samples showed very small variations (~0.3‰/amu). Moreover, lighter-Fe isotopes were enriched in the RBC samples, whilst heavier-Zn isotopes were enriched in the RBC samples. This indicates the clear difference in intake or metabolic efficiencies of these elements. Another interesting feature observed on Fe and Zn isotopes in the RBC samples were that isotopic ratios of Fe for male human bodies were significantly lighter than Fe isotopic composition of female bodies. This indicates that intake efficiency of Fe for male bodies were less effective than that for female bodies. The data presented here demonstrate clearly that the Fe and Zn isotopic ratios obtained by the ICPMS technique can give strong clues to elucidate the isotopic fractionation of transition metals occurring in biochemical reactions. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Takafumi Hirata: "Chemically assisted-Laser ablation-inductively coupled plasma-mass spectrometry"Analytical Chemistry. 76. 228-233 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "In-situ precise isotopic analysis of tungsten using laser ablation-multiple collector-inductively coupled plasma mass spectrometry (LA-Mc-ICPMS) with time resolved data acquisition technique"J.Anal.Atom.Spectrom.. 17. 204-210 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaharu Tanimizu, Yoichi Asada, Takafumi Hirata: "Absolute Isotopic Composition and Atomic Weight of Commercial Zinc Using Inductively Coupled Plasma Mass Spectrometry"Analytical Chemistry. 74. 5814-5819 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata, Takeshi Ohno: "In-situ isotopic ratio analysis of iron using a laser ablation-multiple collector-inductively coupled plasma mass sectrometry (LA-Mc-ICPMS)"J.Anal.Atom.Spectrom.. 16. 487-491 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "Determinations of Zr isotopic composition and U-Pb age for terrestrial and extraterrestrial zircons and baddeleytes using laser ablation-inductively coupled plasma mass spectrometry : implications for Nb-Zr isotopic systematics"Chemical Geology. 176. 323-342 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Michinari Hattori, Takafumi Hirata: "A novel sample decomposition technique at atmospheric pressure for the determination of Os abundances in iron meteorites using isotope dilution inductively coupled plasma-mass spectrometry"The Analyst (London). 126. 846-851 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "Chemically assited-Laser ablation-inductively coupled plasma-mass spectrometry"Analytical Chemistry. 76. 228-233 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "In-situ precise isotopic analysis of tungsten using laser ablation-multiple collector-inductively coupled plasma mass spectrometry (LA-MC-ICPMS) with time resolved data acquisition technique"J. Anal. Atom. Spectrom.. 17. 204-210 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaharu Tanimizu, Yoichi Asada, Takafumi Hirata: "Absolute Isotopic Composition and Atomic Weight of Commercial Zinc Using Inductively Coupled Plasma Mass Spectrometry"Analytical Chemistry. 74. 5814-5819 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata, Takeshi Ohno: "In-situ isotopic ration analysis of iron using a laser ablation-multiple collector-inductively coupled plasma mass spectrometry (LA-MC-ICPMS)"J. Anal. Atom. Spectrom.. 16. 487-491 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "Determinations of Zr isotopic composition and U-Pb age for terrestrial and extraterrestrial zircons and baddeleytes using laser ablation inductively coupled plasma mass spectrometry : implications for Nb-Zr isotopic systematics"Chemical Geology. 176. 323-342 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Michinari Hattori, Takafumi Hirata: "A novel sample decomposition technique at atmospheric pressure for the determination of Os abundances in iron meteorites using isotope dilution inductively coupled plasma-mass spectrometry"The Analyst (London). 126. 846-851 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takafumi Hirata: "In-situ precise isotopic analysis of tungsten using laser ablation-multiple collector-inductively coupled plasma mass spectrometry (LA-MC-ICPMS) with time resolved data acquisition technique"J. Anal. Atom. Spectrom.. 17. 204-210 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masaharu Tanimizu, Yoichi Asada, Takafumi Hirata: "Absolute Isotopic Composition and Atomic Weight of Commercial Zinc Using Inductively Coupled Plasma Mass Spectrometry"Analytical Chemistry. 74. 5814-5819 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takafumi Hirata: "Chemically assisted-Laser ablation-inductively coupled plasma-mass spectrometry"Analytical Chemistry. 76. 228-233 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 平田岳史: "全地球史解読(分担執筆)"東大出版会. 109-130 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takafumi Hirata, Takeshi Ohno: "In-situ isotopic ratio analysis of iron using a laser ablation-multiple collector-inductively coupled plasma mass spectrometry (LA-MC-ICPMS)"J.Anal.Atom, Sectrom.. 16. 487-491 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takafumi Hirata: "Determinations of Zr isotopic composition and U-Pb age for terrestrial and extraterrestrial zircons and baddeleytes using laser ablation-inductively coupled plasma mass spectrometry : implications for Nb-Zr isotopic systematics"Chemical Geology. 176. 323-342 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Michinari Hattori, Takafumi Hirata: "A novel sample decomposition technique at atmospheric pressure for the determination of Os abundances in iron meteorites using isotope dilution inductively coupled plasma-mass spectrometry"The Analyst (London). 126. 846-851 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Fujii, T.Hirata, Y.Shibahara, K.Nishizawa: "Mass -dependent and mass -independent isotopic effects of zinc in chemical exchange reactions using liquid chromatography with a cryptand stationary phase"Phys.Chem.Chem.Phys.. 3. 3125-3129 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Fujii, H.Moriyama, Hirata, K.Nishizawa: "Isotopic effects of hafnium in solvent extraction using crown ethers"Bull.Chem.Soc.. 74. 1031-1032 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 平田岳史: "絶対年代測定法、全地球史解読"大日本出版. 535 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 平田岳史: "地球の誕生と形成直後の進化「マントル・地殻の地球化学地球化学」"培風館. 347 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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