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Synthesis of Silver(I) and Gold(I) Complexes Showing a Variety of Spectra of Antimicrobial Activities and Thier Structure-Activity Correlations

Research Project

Project/Area Number 13640566
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic chemistry
Research InstitutionKanagawa University

Principal Investigator

NOMIYA Kenji  Kanagawa University, Faculty of Science, Professor, 理学部, 教授 (80119354)

Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordssilver(I) complexes / gold(I) complexes / bismuth(III) complexes / antimicrobial activities / structure-activity correlation / thiosemicarbazone ligands / hinokitiol ligand / amino-acid ligands / 抗菌抗カビ活性 / X線構造解析 / Rietveld解析 / 2-メルカプトプロピオン酸 / 6-メルカプトニコチン酸 / 配位子交換性 / ヒノキチオール配位子 / チオセミカルバゾン配位子 / 抗菌スペクトル
Research Abstract

Several novel results in this research were obtained :
1. Water-soluble silver(I) complexes with amino-acid ligands such as glycine, aspartic acid and asparagines, showing wide spectra of effective antimicrobial activities, were synthesized and their structures in the solid-state and in solution were characterized. Such complexes were classified into four based on bonding modes of the silver center.
2. Selective and effective antimicrobial activities against Gram-positive bacteria found in 2-coordinate gold(I)-PPh_3 complexes with AuSP and AuNP cores were discussed based on ligand-exchange reactions with aliphatic thiol ligands such as D-penicillamine and 2-mercaptopropionate.
3. Several silver(I) complexes such as "molecular metal wheel" -type Ag_8 cluster formed by 2-mercaptopropionate and PPh_3 ligands and "cyclohexane-chair" -type Ag_6 cluster formed by 2-mercaptonicotinate were synthesized and their crystal/molecular structures determined. Gold(I) complex formed by 2-mercaptopropionate and PPh_3 ligands, and that formed by 6-mercaptonicotinate and PPh_3 ligands showed supramolecular arrangement of 2-coordinate AuSP cores.
4. Structure-activity correlations in the antimicrobial activities by several metal complexes with thiosemicarbazone and hinokitiol ligands have been studied. Antimicrobial activities by metal complexes were strongly dependent on the metal centers rather than their molecular structures. The complexes with similar core-structures of the same metal center showed similar spectra of antimicrobial activities.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] K.Nomiya, H.Yokoyama: "Structures and antimicrobial activities of silver(I) complexes with amino acids"J.Chem.Soc., Dalton Trans.. 2483-2490 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Structure of a Molecular Metal Wheel, an Octanuclear Silver(I) Cluster"Chem.Lett.. 922-923 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Structure of hexanuclear silver(I) nicotinate cluster"Inorg.Chem.. 42. 8028-8032 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Ligand-exchangeability of 2-coordinate phosphinegold(I) complexes"J.Inorg.Biochem.. 95. 208-220 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Silver(I), aluminium(III) and cobalt(II) complexes with hinokitiol"J.Inorg.Biochem.. 98. 46-60 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya, H.Yokoyama: "Synthesis, crystal structure and antimicrobial activities of polymeric silver(I) complexes with three amino acids (aspartic acid (H_2asp), glycine (Hgly) and asparagines (Hasn)"J.Chem.Soc., Dalton Trans.. 2483-2490 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Synthesis and Structure of a Molecular Metal Wheel, an Octanuclear Silver(I) Cluster Formed by Racemic 2-Mercaptopropionic Acid and Triphenylphoshine Ligands"Chem.Lett.. 410-411 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] I.Tsyba et al.: "Synthesis and Structure of a Water-Soluble Hexanuclear Silver(I) Nicotinate Cluster Comprised of a "Cyclohexane-Chair"-Type of Framework, Showing Effective Antibacterial and Antifungal Activities : Use of "Space Matrix" Techniques for Growing Crystals of Water-Soluble Inorganic Complexes"Inorg.Chem.. Vol.42. 8028-8032 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Ligand-exchangeability of 2-coordinate phosphinegold(I) complexes with AuSP and AuNP cores showing selective antimicrobial activities against Gram-positive bacteria. Crystal structures of [Au(2-Hmpa)(PPh_3)] and [Au(6-Hmna)(PPh_3)](2-H_2mpa=2-mercaptopropionic acid, 6-H_2mna=6-mercaptonicotinic acid)"J.Inorg.Biochem.. Vol.95. 208-220 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] N.C.Kasuga et al.: "Synthesis, structural characterization and antimicrobial activities of twelve zinc(II) complexes with four thiosemicarbazones and two semicarbazone ligands"J.Inorg.Biochem.. Vol.96. 298-310 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Synthesis, solid-state characterization and antimicrobial activities of three different polymorphs of a copper(II) complex with 4-isopropyltropolone (hinokitiol)"Inorg.Chim.Acta. Vol.357. 1168-1176 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities"J.Inorg.Biochem.. Vol.98. 46-60 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Syntheses, crystal structures and antimicrobial activities of monomeric 8-coordinate, and dimeric and monomeric 7-coordinate bismuth(III) complexes with tridentate and pentadentate thiosemicarbazones and pentadentate semicarbazone ligands"J.Inorg.Biochem.. Vol.98. 601-615 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] K.Nomiya et al.: "Structure of hexanuclear silver(I) nicotinate cluster"Inorg.Chem.. 42. 8028-8032 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya et al.: "Silver(I), aluminium(III) and cobalt(II) complexes with hinokitiol"J.Inorg.Biochem.. 98. 46-60 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya et al.: "Ligand-exchangeability of 2-coordinate phosphinegold(I) complexes"J.Inorg.Biochem.. 95. 208-220 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya et al.: "Twelve zinc(II) complexes with thiosemicarbazones and semicarbaones"J.Inorg.Biochem.. 96. 298-310 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya et al.: "Three different polymorphs of copper(II) complex with hinokitiol"Inorg.Chim.Acta. 357. 1168-1176 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya: "Bismuth (III) complexes with thiosemicarbazones and semicarbazones"J.Inorg.Biochem.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] K.Nomiya, H.Yokoyama: "Structures and antimicrobial activities of silver(l) complexes with amino acids"J.Chem.Soc., Dalton Trans.. 2483-2490 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Nomiya et al.: "Structure of a Molecular Metal Wheel, an Octanuclear Silver(l) Cluster"Chem.Lett.. 922-923 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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