The correlation between the charge-transfer-rate and bases alignment in a DNA molecule : Study with STM/STS
| Project/Area Number |
13640585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
機能・物性・材料
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| Research Institution | Hosei University |
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Principal Investigator |
MARUYAMA Yuusei Hosei University, Faculty of Engineering, Professor, 工学部, 教授 (40013479)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | DNA / STM / STS / charge-transter / tunneling spectroscopy |
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| Research Abstract |
It was suggested that the charge transfer rate through the base molecules in a double-helix DNA molecule is strongly dependent on the base-pairs alignment in a biochemical analysis. In this study we directly observed the energy spectra of the electron-density of states just on the each base-site with using scanning tunneling microscopy/spectroscopy. We compared the spatially-resolved tunneling spectra of DNA(poly(dA-dT) ・ poly(dA-dT)) with those of DNA(poly(dG-dC) ・ poly(dG-dC)) and found out that the latter has the higher electron energy for the shallowest DOS peak in the valence band. This fact means that a (G-C) pair performs as a lower barrier for holes compared with an (A-T) pair. This conclusion is consistent with the elucidation by the biochemical approach.
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Report
(3 results)
Research Products
(8 results)
