• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Group recognition for Natural Toxic Compounds based on Their Toxicity and Its Contribution to Rapid Analysis

Research Project

Project/Area Number 13640604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionKyoto Institute of Technology

Principal Investigator

HOSOYA Ken  Kyoto Inst. of Tech., Dept of Polymer Sci., Associate Professor, 繊維学部, 助教授 (00209248)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsFragment Imprinting Method / Artificial Receptor / Mycrocystins / Pre-treatment / HPLC / Molecular Imprinting / Toxicity Recognition / Nano-technology / 人工レセプター / ナノテクノロジ
Research Abstract

The following results have been obtained along 2 years' project.
1)Development of novel fragment imprinting method
For a naturally occurring toxic compound, Microcystin, the novel fragment imprinting method was applied using Adda functional group as pseudo-template molecule. Interestingly, even alkylbenzenes could be utilized as effective pseudo-template to Microcystins, in addition, relatively loose molecular recognition ability based on alkylbenzene imprinted polymer was found to realize effective group recognition of Microcystins. This recognition was found to be based on their toxicity recognition.
2)Group recognition based on toxicity recognition
In addition to the results described above, an imprinting for glutamic acid moiety was also quite effective for the group recognition. This was found to be based on interesting exclusion mechanism for other less important functional groups of Microcystins.
3)Pre-treatment of environmental water
the separation media obtained showed concentration effect of the target homologues, while other contaminants were easily excluded from the separation media. This is very important because much easier pre-treatment can be done using the obtained separation media.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Ken HOSOYA: "Preparation strategy for uniformly sized, polymer-based HPLC packing materials having practically acceptable column efficiency. 1. Copolymerization technique"Analytical Chemistry. 73/24. 5852-5857 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken HOSOYA: "Design and valid "surface" property of polymer-based separation media for capillary electrochromatography (CEC) : Correlation between separation selectivity, retentivity, and gene"Chroamtography. 22/3. 187-193 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Selective Surface Modification Technique for Improvement of Chromatographic Separation selectivity for Sugar Derivative"Analytical Science. 18. 55-58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Novel surface modification of polymer-based separation media controlling separati on selectivity, retentivity and generation of electroosmotic flow"Journal of Chromatography A. 979. 3-10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "A possible purification method of DNAs' fragments from humic matters in soil extracts using novel stimulus responsive polymer adsorbent"Journal of Pharmaceutical and Biomedical Analysis. 30. 1919-1922 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "On column concentration of bisphenol A with one-step removal of humic acids in water"Journal of Chromatography A. 987. 389-394 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Molecularly Imprinted Polymer"John Willey(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Preparation strategy for uniformly sized, polymer-based HPLC packing materials having practically acceptable column efficiency. 1"Anal. Chem.. 73(24). 5852-5857 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Design and valid surface property of polymer-based separation media for capillary electrochromatography (CEC): Correlation between separation selectivity, retentivity, and generation of electroosmotic flow."CHROMATOGRAPHY. 22(3). 187-193 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Selective Surface Modification Technique for Improvement of Chromatographic Separation selectivity for Sugar Derivatives"Anal. Sci.. 18. 55-58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Novel surface modification of polymer-based separation media controlling separation selectivity, retentivity and generation of electroosmotic flow"J. Chromatogr. A. 979. 3-10 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "A possible purification method of DNAs' fragments from humic matters in soil extracts using novel stimulus responsive polymer adsorbent"J. Pharm. and Biomed. Anal.. 30. 1919-1922 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "On-column concentration of bisphenol A with one-step removal of humic acids in water"J. Chromatogr. A. 987. 389-394 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya: "Molecularly Imprinted Polymer"John Willey (In Press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ken Hosoya他: "Preparation strategy for uniformly sized, polymer-based HPLC packing materials having practically acceptable column efficiency. 1. Copolymerization technique"Analytical Chemistry. 73・24. 5852-5857 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "Design and valid"surface"property of polymer-based separation media for capillary electrochromatography (CEC) : Correlation between separation selectivity, retentivity, and generation of electroosmotic flow"Chromatography. 22・3. 187-193 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "Selective Surface Modification Technique for Improvement of Chromatographic Separation selectivity for Sugar Derivatives"Analytical Science. 18. 55-58 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "Novel surface modification of polymer-based separation media controlling separation selectivity, retentivity and generation of electroosmotic flow"Journal of Chromatography A. 979. 3-10 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "A possible purification method of DNAs' fragments from humic matters in soil extracts using novel stimulus responsive polymer adsorbent"Journal of Pharmaceutical and Biomedical Analysis. 30. 1919-1922 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "On column concentration of bisphenol A with one-step removal of humic acids in water"Journal of Chromatography A. 987. 389-394 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya他: "Molecularly Imprinted Polymer"John Willey(印刷課程)(仮題).

    • Related Report
      2002 Annual Research Report
  • [Publications] Ken Hosoya 他: "Monodisperse polymer-based stationary phase for carbohydrate analysis by reduced -diameter coulumn anion -exchange chromatography with pulsed amperometric detector"Journal of Microcolumn Separations. 13. 8-12 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya: "Preparation strategy for uniformly sized, polymer -based HPLC packing,materials having practically acceptable colum n effciency. 1. Copolymerization technique"Analytical Chemistry. 73・24. 5852-5857 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya 他: "Design and valid "surface"property of polymer -based separation media for c apillary electrochromatography (CEC) : Correlation between separation selectivity, retentivity, and generation of electroosmotic flow"Chromatography. 22・3. 187-193 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya 他: "Selective Surface Modification Technique for Improvement of Chromatographic Separation selecitivity for Sugar Derivatives"Analytical Science. 18. 55-58 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya 他: "Capillary Electrochromatography on Monolithic Silica Columns"Analytical Science. 18. 89-92 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya 他: "Monolithic Silica Columns for High -Efficiency Separations by HPLC"Journal of Chromatography A. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken Hosoya 他: "Molecular Imprint (仮題)"John Wiley(印刷中).

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi