Noninvasive Measurement of Temperature Distribution in Tissues by Ultrasonic CT
| Project/Area Number |
13650241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thermal engineering
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| Research Institution | Yatsushiro National College of Technology |
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Principal Investigator |
NAWATA Yutaka Yatsushiro National College of Technology, Professor, 機械電気工学科, 教授 (30037890)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Ultrasonic Sound / Computed Tomography / Temperature Measurement / Tissue / Sound speed |
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| Research Abstract |
It is necessary to measure the temperature distributions in tissues during hyperthermia which is a treatment of cancer. We have anticipated a technology measuring indirectly the interior temperature distribution of the arbitrary transverse section in tissues and displaying the image for monitoring.
We can obtain the sound speed distribution within the object by measuring the transit time of sound wave with ultrasonic CT. The purpose of this study is to develop a method measuring indirectly the temperature distribution in tissues from the differences in sound speed before and after heating, using the characteristics that sound speed depends on the temperature.
The first experiment we made was about the dependence of temperature on sound speed in water, agar and several excised tissues, and we obtained some relations between the temperature and the sound speed.
Then, the phantom made of agar was placed in a water bath. A series of sound projections was measured before and after heating by ultrasonic CT method. We obtained the distribution of the temperature differences below 1℃ in phantom by subtracting the sound distribution before heating from after heating.
Next, we made the experiment with excised tuna in a water bath. But we were not able to measure the temperature difference below 1℃ in tuna. This is because the difference in sound speed between tuna and water is much more than the difference between agar and water. Tissue has to be placed in liquid which has the sound speed close to the sound speed in tissue in order to obtain the temperature distribution in tissue.
We can make the glucose solution having a given sound speed by changing the concentration. We measured the dependence of sound speed in glucose solution on temperature and concentration. Then we made the experiment with excised tuna and glucose solution having the sound speed close to tuna's. As a result, We were able to measure the temperature difference below 1℃ in excised tuna.
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Report
(4 results)
Research Products
(15 results)
