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Clinico-Pharmacological Studies of 1,25(OH)_2D_3 to Hypocalcemia in Cows.

Research Project

Project/Area Number 13660313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionIwate University

Principal Investigator

NAITO Yoshihisa  Iwate University, Faculty of agriculture Professor, 農学部, 教授 (40003785)

Co-Investigator(Kenkyū-buntansha) YAMAGISHI Norio  Obihiro University Associate professor, 畜産学部, 助教授 (30281877)
OKADA Keiji  Iwate University Associate professor, 農学部, 助教授 (60233326)
SATO Jun  Iwate University Assistant professor, 農学部, 助手 (30250632)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordscows / hypocalcemia / 1,25(OH)_2D_3 / calcium metabolism / post-parturient disease / milk fever / TRAP / 骨代謝 / TRAP / 予防 / 1,25(OH)_2D_3
Research Abstract

1. In the first study, 1,25-dihydroxyvitamin D_3 [1,25(OH)_2D_3] was injected into late-pregnant cows 12-48 hours prepartum to evaluate the effect of 1,25(OH)_2D_3 for prevention of parturient hypocalcemia. Twelve Holstein cows, at least second parity, were assigned to two groups. Seven cows received 1 μg/kg of 1,25(OH)_2D_3 (1,25(OH)_2D_3 group) in ethanol, and the other five received only ethanol (control group). All cows calved 12-48 hours after administration. Plasma 1,25(OH)_2D_3 concentration in 1,25(OH)_2D_3 group was significantly higher 1 day pre- to 0.5 day postpartum than in control group. Plasma Ca and iP levels in 1,25(OH)_2D_3 group kept high near parturition, and were significantly higher than those in control group from 0.5 day before parturition to 2 days after parturition.
In conclusion, it was considered that the intramuscular injection of 1,25(OH)2D3 before 1-2 day(s) of calving had prophylactic effect for parturient hypocalcemia.
2. The aim of the second study was to investigate association between occurrence of milk fever and bone metabolism. To observe changes in bone metabolism and associations between it and the development of milk fever, we investigated serum tartrate-resistant acid phosphatase (TRAP) activity at each lactating stage n 83 cows.
In this study, it was confirmed utilization of Trap activity in serum for evaluation of bone metabolism in cow. Occurrence of milk fever thought to be related with inactive bone metabolism from the finding of low TRAP activity in milk fever frequent farm. It was thought that measuring of serum TRAP activity was applied to prevent milk fever.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Sato, J., Sato, R., Takagi, A., Goto, T., Okada, K., Yasuda, J., Naito, Y.: "Association between changes in plasma calcium concentration and plasma tartrate-resistant acid phosphatase activity in periparturient cows"J. Vet. Med. Sci.. 65. 291-293 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato, J., Okada, K., Fukuda, S., Sato, R., Yasuda, J., Naito, Y.: "Serum activities of tartrate-resistant acid phosphatase and bone specific alkaline phosphatase as indices of bone metabolism in the cow"J. Vet. Med. Sci.. Sci.. 653-655 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤 淳, 岡田啓司, 佐藤れえ子, 安田 準, 内藤善久: "乳熱多発農家と低発生農家における乳牛の血清酒石酸耐性酸ホスファターゼ活性値"日獣会誌. 55. 580-583 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamagishi, N., Kobayashi, S., Miyamoto, A., Soehartono, R.H., Lee, I.H., Miyahara, K., Naito, Y., Yamada, H.: "Plasma atrial natriuretic peptide concentrations in hypocalcaemic cows. Vet. Rec. 148. 628-629"Vet. Rec. 148. 628-629 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato, J., Sato, R., Takagi, A., Goto, T., Okada, K., Yasuda, J., Naito, Y.: "Association between changes in plasma calcium concentration and plasma tartrate-resistant acid phosphatase activity in periparturient cows"J. Vet. Med. Sci.. 65. 291-293 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato, J., Okada, K., Fukuda, S., Sato, R., Yasuda, J., Naito, Y.: "Serum activities of tartrate-resistant acid phosphatase and bone specific alkaline phosphatase as indices of bone metabolism in the cow"J. Vet. Med. Sci.. 64. 653-655 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato, J., Okada, K., Sato, R., Yasuda, J., Naito, Y.: "Serum activities of tartrate-resistant acid phosphatase in cows from farms where milk fever was frequent and farms where it was rare"J. Jpn. Med. Assoc.. 55. 580-583 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamagishi, N., Kobayashi, S., Miyamoto. A., Soehartono, R. H., Lee, I. H., Miyahara, K., Naito, Y., Yamada, H.: "Plasma atrial natriuretic peptide concentrations in hypocalcaemic cows"Vet. Rec.. 148. 628-629 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 内藤善久, 佐藤 淳, 岡田啓司他: "乳熱多発農家と低発生農家における乳牛の血清酒石酸耐性酸ホスファターゼ活性値"日本獣医会雑誌. 55・9. 580-583 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamagishi, N., Naito, Y., et al.: "Effects of administration of 1,25(OH)_2D_3 on Ca metabolism in cows(発売予定)"J.Vet.Mcd.Sci.

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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