| Project/Area Number |
13670039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Gifu University |
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Principal Investigator |
ERA Seiichi School of Medicine, Professor, 医学部, 教授 (30152002)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Tomoya Department of Physiology, Meiji University of Oriental Medicine, Research Assistant, 医療技術短期大学部, 助手 (70293561)
NAKAMURA Koji Department of Medical Technology, Gifu College of Medical Technology, Associate Professor, 講師 (70242724)
KUWATA Kazuo School of Medicine, Assistant Professor, 医学部, 助教授 (00170142)
KINOSADA Yasutomi University Hospital, Professor, 医学部・附属病院, 教授 (50161526)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | free water / unfrozen water / restricted water / synthetic copolymer gels / MRI / DSC / magnetization transfer |
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| Research Abstract |
A prospective study was performed to investigate the correlations between saturation transfer ratio (STR) and histological parameters of invasive ductal carcinomas in human breast. The histological parameters investigated were the extent of fibrosis in the intracellular matrix, dysplastic changes of nuclei, and mitotic index. Twenty-seven patients with breast carcinoma were examined using an off-resonance saturation pulse in conjunction with conventional field-echo T_1-weighted imaging at frequency offsets of 448 Hz and 1200 Hz from water resonance. The values of STR at frequency offset of 1200 Hz (STR_<1200>) increased from non-scirrhous carcinoma to scirrhous carcinoma. Although STR_<1200> showed correlation with the extent of fibrosis in the intracellular matrix, they did not correlate with the dysplastic changes of nuclei or mitotic index. On the other hand, the values of STR at frequency offset of 448 Hz (STR_<448>) demonstrated close correlation to dysplastic changes of nuclei and mitotic index. STR_<1200> correlates with the structural characteristics and STR_<448> correlates with the nature of malignant cells with regard to nuclear dysplasia and mitotic potential.
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