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Hepatic-portal leptin sensor regulates energy metabolism

Research Project

Project/Area Number 13670067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionOITA MEDICAL UNIVERSITY

Principal Investigator

YOSHIMATSU Hironobu  Oita university, department of internal medicine 1, Professor, 医学部, 教授 (00166993)

Co-Investigator(Kenkyū-buntansha) KAKUMA Tetsuya  Oita university, department of internal medicine 1, 医学部, 助手 (80343359)
坂田 利家  大分医科大学, 医学部, 教授 (50037420)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordshepatic-portal vein / leptin / feeding behavior / energy metabolism / brown adipose tissue / adiponectin / 神経ヒスタミン / 交換神経 / 交感神経 / 視床下部
Research Abstract

Present study aimed to clarify the functional role of hepatic-portal, leptin sensor in regulation of energy metabolism. Hepatic-portal infusion of leptin at a dose of 1000 μg/rat suppressed 24-h cumulative food intake and increased activity of sympathetic nerve innervating brown adipose tissue (BAT). However, that treatment with small dosage of leptin did not affect food intake nor nerve activity. Administration of leptin into the hepatic-portal vein decreased mRNA expression of sterol regulatory element binding protein and its downstream enzymes related with lipogenesis. Administration of histamine into the third cerebroventricle induced c-fos expressions in the paraventricular nucleus and the arcuate nucleus. In extrahypothalamic regions, c-fos expression was observed in the hippocampus and the amygdala. Intra-peritoneal administration of adiponectin (1.5mg/kg for 7 days) attenuated body weight gain and reduced visceral adiposity in agouti yellow (A^y/a) obese mice. In addition, adiponectin treatment increased mRNA expression of UCP1 mRNA in the BAT. Furthermore, peripheral administration of adiponectin (1.5mg/kg, one shot) increased BAT sympathetic nerve activity accompanied by an increase of body temperature. These above responses were not induced by central application of adiponectin (15μg/kg). In summary, present study indicate that hepatic-portal leptin sensor may regulate lipid metabolism in the liver, but adiponectin may regulate energy metabolism through action of its hepatic-portal sensor.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Masaki T, et al.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice"Diabetes. 50. 376-384 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabetes. 50. 385-391 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katsuragi I, et al.: "Transplantation of normal islets into the portal vein of Otsuka Long Evans Tokushima Fatty rats prevents diabetic progression"Exp Biol Med. 226. 681-685 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histamine neurons down-regulate ob gene expression in rat white adipose tissue"Inflamm Res. 50. 72-73 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka S, et al.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"J Neurochem. 77. 993-1000 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine"Exp.Biol.Med. 227. 63-68 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka S, et al.: "Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J. 16. 509-518 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tuda K, et al.: "Hypothalamic histamine neurons activate lipolysis in rat adipose tissue"Exp.Biol.Med. 227. 208-213 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H, et al.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur.J.Clin.Invest. 32. 236-241 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuruta Y, et al.: "Hyperleptinemia in A y /a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression"Am J Physiol Endocrinol Metab.. 282. E967-E973 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice"Diabetes. 52. 2266-2273 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obese mice"Endocrinology. 144. 2741-2748 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki T, et al.: "Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity, and uncoupling protein expression in mice"Endocrinology. 144. 3547-3554 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki, T., Yoshimatsu, H., Chiba, S., Watanabe, T, Sakata, T.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice"Diabetes. 50. 376-384 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki, T., Yoshimatsu, H, Chiba, S., Watanabe, T., Sakata T.: "Targeted disruption of histamine Hi-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabetes. 50. 385-391 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katsuragi, L, Okeda, T., Yoshimatsu, H., Utsunomiya, N., Ina, K, Sakata, T.: "Transplantation of normal islets into the portal vein of otsuka long evans tokushima fatty rats prevents diabetic progression"Exp Biol Med. 226. 681-685 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Hidaka, S., Niijima, A., Sakata, T.: "Histamine neurons down-regulates ob gene expression in rat white adipose tissue"Inflamm Res.. 50. 72-73 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka, S., Yoshimatsu, H., Kondou, S., Oka, K, Tsuruta, Y., Sakino, H., Itateyama, E., Noguchi, H., Himeno, K, Okamoto, K, Teshima, Y., Okeda, T., Sakata, T.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"J Neurochem. 77. 993-1000 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu, H, Chiba, S., Tajima, D., Akehi, Y., Sakata, T.: "Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine"ExBiol.Med.. 227. 63-68 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hidaka, S., Yoshimatsu, H, Kondou, S., Tsuruta, Y., Oka, K, Noguchi, H, Okamoto, K, Sakino, H, Teshima, Y., Okeda, T., Sakata T.: "Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J. 16. 509-518 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tuda, K, Yoshimatsu, H., Nijima, A, Chiba, S., Sakata T.: "Hypothalamic histamine neurons activate lipolysis in rat adipose tissue"ExBiol.Med.. 227. 208-216 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu, H., Tsuda, K., Niijima, A., Talsukawa, M., Chiba, S., Sakata, T.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur.J.Clin.Invest.. 32. 236-241 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuruta, Y., Yoshimatsu, H., Hidaka, S., Kondou, S., Okamoto, K., Sakata, T.: "Hyperleptinemia in A y /a mice upregulates arcuate cocaine-and amphetamine-regulated transcript expression"Am J Physiol Endocrinol Metab. 282. E967-E973 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki, T., Chiba, S., Yasuda, T., Tsubone, T., Kakuma, T., Shimomura, I., Funahashi, T., Matuzawa, Y., Yoshimatsu, H.: "Peripheral, but not central, administration of Adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow(Ay/a) obese mice"Diabetes. 52. 2266-2273 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki, T., Chiba, S., Yoshimichi, G., Yasuda, T., Noguchi, FL, Kakuma, T., Sakata, T., Yoshimatsu, H.: "Neuronal histamine regulates food intake, adiposity and uncoupling protein expression in agouti yellow (A^y/a) obese mice"Endocrinology. 144. 2741-2748 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masaki, T., Chiba, S., Yoshimichi, G., Yasuda, T., Noguchi, H., Kakuma, T., Sakata, T., Yoshimatsu, H.: "Corticotropin-releasing hormone-mediated pathway of leptin to regulate feeding, adiposity, and uncoupling protein expression in mice"Endocrinology. 144. 3547-3554 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshimatsu H et al.: "Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine"Exp. Biol. Med.. 227. 63-68 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hidaka S et al.: "Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J.. 16. 509-518 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tuda K et al.: "Hypothalamic histamine neurons activate lipolysis in rat adipose tissue"Exp. Biol. Med.. 227. 208-213 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshimatsu H et al.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur. J. Clin. Invest.. 32. 236-241 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuruta Y et al.: "Hyperleptinemia in A y/a mice upregulates arcuate cocaine-and amphetamine-regulated transcript expression"Am J Physiol. 282. E967-E973 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshimatsu H.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur.J.Clin.Invest.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hidaka S.: "Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats"FASEB J.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsuda K.: "Hypothalamic histamine neurons activate lipolysis in rat adipose tissue"Exp.Biol.Med.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimatsu H.: "Histidine suppresses food intake through its conversion into neuronal histamine"Exp.Biol.Med.. 21. 63-68 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki T.: "Targeted disruption of histamine H_1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice"Diabetes.. 50. 385-391 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki T.: "Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice"Diabetes.. 50. 376-384 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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