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Mechanism of prolactin action on induction of development, enlargement and inflammation of prostate -study with prolactin knockout mice-

Research Project

Project/Area Number 13670136
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionNippon Veterinary and Animal Science University (2002)
Mie University (2001)

Principal Investigator

TANAKA Minoru  Nippon Veterinary and Animal Science University, Department of Nippon Veterinary and Animal Science University, Professor, 獣医畜産学部, 教授 (90024736)

Co-Investigator(Kenkyū-buntansha) OHTA Yoshiyuki  Nippon Veterinary and Animal Science University, Department of Nippon Veterinary and Animal Science University, Lecturer, 獣医畜産学部, 講師 (00277667)
中井 直也  三重大学, 医学部, 助手 (90324508)
藤川 隆彦  三重大学, 医学部, 講師 (60293776)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsprolactin / prostate / inflammation / knockout mouse / prolactin receptor / gene expression / bisphenol A / 遺伝子発現調節 / 遺伝子
Research Abstract

It is suggested that chronic hyperprolactinemia in infant mice induced by estrogen causes inflammation in the prostate. To prove the prolactin action on the prostate, extents of inflammation in wild-type and prolactin-knockout (PRL-KO) mice were examined after administration of an estrogenic compound, bisphenol A. The myeloperoxidase activity in the wild-type mice was increased by the treatment, but the activity remained at basal level in PRL-KO mice. These results indicate mat the inflammation ** the prostate is mediated by PRL. In order to clarify the molecular mechanisms of PRL action on the prostate, PRL-receptor (PRL-R) gene expression was analyzed. In addition of the known three first exons, El-1, El-2 and El-3, two novel first exons, El-4 and El-5, were identified in rat PRL-R gene. Each first exon is expressed in a tissue-specific manner. RT-PCR analysis repealed the expression of El-3 exon in the prostate. It has been known that the expression of El-3 was regulated by SP-1 and C/EBPβ, suggesting that the expression of PRL-R gene in the prostate is regulated by these two transcription factors.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Minoru Tanaka: "Identification of a novel first exon of prolactin receptor gene expressed in the rat brain"Endocrinology. 143. 2080-2084 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minoru Tanaka: "Brain-specific control of prolactin receptor gene expression correlated with induction of maternal behavior in the rat"Journal of Reproduction and Development. 48. 103-110 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minoru Tanaka: "Identification of a novel first exon of prolactin receptor gene expressed in the rat brain"Endocrinology. 143-6. 2080-2084 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minoru Tanaka: "Brain-specific control of prolactin receptor gene expression correlated with induction of maternal behavior in the rat"Journal of Reproduction and Development. 48-2. 103-110 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minoru Tanaka: "Identification of a novel first exon of prolactin receptor gene expressed in the rat brain"Endocrinology. 143・6. 2080-2084 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minoru Tanaka: "Brain-specific control of prolactin receptor gene expression correlated with induction of Maternal behavior in the rat"Journal of Reproduction and Development. 48・2. 103-110 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minoru Tanaka: "Brain-specific control of prolactin receptor gene expression correlated with induction of maternal behavior in the rat"Journal of Reproduction and Development. (発表予定).

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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