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Analysis of Hswi1 in neuroendocrine tumor

Research Project

Project/Area Number 13670177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKochi Medical School

Principal Investigator

TAKEUCHI Tamotsu  Dept. of Pathology, Kochi Medical School Asist. Prof., 医学部, 助手 (50226990)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordshSWI1 / neuroblastoma / T-cadherin / hSWI1 / neuroblastoma / T-cagherin / 神経芽細胞腫 / クロマチン再構成因子 / ヒトSWI1 / 乳癌 / 滑膜肉腫
Research Abstract

In the present study, we cloned and mapped a B120 gene, as a truncated human SWI1 gene, to human chromosome 1p35-36.1 where possible suppressor genes for various neuroendocrine tumors including neuroblastoma have been mapped. Expression of the B120 gene product was immunohistochemically investigated in various neuroendocrine tumors including neuroblastomas. We also examined cell-cell adhesion molecule including T-cadherin as an induced molecule by B120 overexpression in various tumors. We further explored that T-cadherin molecule was down-regulated by epigenetic events in many cancers.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 竹内 保: "神経分子生物学、細胞接着因子の項目"医学大辞典(医学書院). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katoh, Hiroyuki: "SYT associated with human SNF/SUI Complexes and the C-terminal region of its fusion partner"J. Biol. Chem.. 277. 5498-5505 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, Tamotsu: "Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma"Lab. Invest.. 82. 1023-1029 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, Tamotsu: "Down-regulation of expression of a novel cadherin molecule, T-cadherin, in Basal cell carcinoma"Mol. Carcinogenesis. 35. 173-179 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, Tamotsu: "Recent Progress in Neurochemistry 2003"Research Signpost (In press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi,Tamotsu et al.: "Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma"Lab. Investigation. Vol.82. 1023-1029 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, Tamotsu et al.: "Down-regulation of expression of a novel cadherin molecule, T-cadherin, in basal cell carcinoma"Mol. Carcinogenesis. Vol.35. 173-179 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Katoh, Hiroyuki, ---, Takeuchi, Tamotsu et al.: "SYT associated with human SNF/SWI Complexes and the C-terminal region of its fusion partner"J. Biol. Chemistry. Vol.277. P5498-P5505 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeuchi, Tamotsu and Yuji Ohtsuki: "Recent Progress in Neurochemistry 2003"Research Siga-post. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 竹内保(分担執筆): "神経分子生物学,細胞接着因子の項目"医学大辞典(医学書院). (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeuchi, Tamotsu: "Recent progress in Neurochemistry"Recent Research Developments in Neurochemistry(Research Signpost). (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Katoh, Hiroyuki: "SYT Associates with Human SNF/SWI Complexes and the C-terminal Region of Its Fusion Partner SSX1 Targets Histones"J.Biol.Chem.. 277. 5498-5505 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeuchi, Tamitsu: "Loss of T-Cadherin (CDH13, H-Cadherin) Expression in Cutaneous Squamous cell Carcinoma"Lab Invest. 82. 1023-1029 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeuchi, Tamitsu: "Down-regulation of expression of a novel cadherin molecule, T-cadherm, in basal cell carcinoma"Mol.Carcinogenesis. 35. 173-179 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takeuchi, T et al.: "Recent progress in T-cadlevin research (Review)"Histol Histopathology. 16. 1287-1293 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Liang et al.: "Reduced human mismatch repair protein in the development of precancerous skin lesion"Virchow Arch. 439. 622-627 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Zhou et al.: "Expression of T-cadherin in human keratinocytes"J.Invest Dermat. (In press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato, H. et al.: "SYT associates with human SNF/SWI complexes"J.Biol.Chem.. 277. 5498-5505 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeuchi, T. et al.: "Loss of T-cadherin expression in autareous squamous cell carainoma"Lab.Invest.. (Submitted).

    • Related Report
      2001 Annual Research Report
  • [Publications] Taniuchi, K. et al.: "Developmental Expression of CA-RPVIII, x and x1 in the human brain"Neuroscience. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 竹内 保(共同執筆): "医学書院 医学大辞典"医学書院(予定). (2003)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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