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Molecular pathological study of prognostic factor in node-negative breast cancer patients

Research Project

Project/Area Number13670181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKagoshima University

Principal Investigator

UMEKITA Yoshihisa  Kagoshima University, Faculty of Medicine, Associate professor, 医学部, 助教授 (80244226)

Project Period (FY) 2001 – 2002
Project Status Completed(Fiscal Year 2002)
Budget Amount *help
¥1,800,000 (Direct Cost : ¥1,800,000)
Fiscal Year 2002 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 2001 : ¥900,000 (Direct Cost : ¥900,000)
KeywordsBreast cancer / Micrometastases / maspin / Immunohistochemistry / micrometastasis / breast cancer / prognosis
Research Abstract

The most important subgroup of breast cancer patients for whom reliable prognostic factors are needed is women without axillary lymph node metastases. I investigated the clinical significance of occult micrometastases in axillary lymph nodes in 148 consecutive "node-negative" breast cancer patients. Occult micrometastases were detected in 21 of 148 patients (14.2%) by means of immunohistochemical analyses using cytokeratine antibodies and a single unstained section after routine histopathological examination. Log-rank tests showed that the 7-year disease-free survival (DFS) and overall survival (OS) rates by Kaplan-Meier methods were significantly better in patients without occult micrometastases than in patients with occult micrometastases (DFS; p=0.0009, OS; p=0.0001). According to Cox's multivariate analysis, the presence of occult micrometastases had the most significant effect on DFS (p=0.0053) and OS (P=0.0035). These findings suggest that the presence of occult micrometastases is an independent and significant predictor of clinical outcome, and that their immunohistochemical detection after routine histopathological examination is useful for selecting the "node-negative" breast cancer patient subgroup at high risk for relapse and death.

Report

(3results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

Research Products

(10results)

All Other

All Publications

  • [Publications] 梅北 善久: "Clinical significance of occult micrometastases in axillary lymph nodes in "node-negative" breast cancer patients"Japanese Journal of Cancer Research. 93. 695-698 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 梅北 善久: "Expression of maspin predicts poor prognosis in breast cancer patients"International Journal of Cancer. 100. 452-455 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 梅北 善久: "Expression of maspin is up-regulated during the progression of mammary ductal carcinoma"Histopathology. (印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshihisa Umekita, et al.: "Clinical significance of occult micrometastases in axillary lymph nodes in "node-negative" breast cancer patients"Japanese Journal of Cancer Research. 93. 695-698 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshihisa Umekita, et al.: "Expression of maspin predicts poor prognosis in breast cancer patients"International Journal of Cancer. 100. 452-455 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshihisa Umekita, et al.: "Expression of maspin is up-regulated during the progression of mammary ductal carcinoma"Histopathology. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 梅北 善久: "Clinical significance of occult micrometastases in axillary lymph nodes in node "negative" breast cancer patients"Japanese Journal of Cancer Research. 93. 695-698 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 梅北 善久: "Expression of maspin predicts poor prognosis in breast cancer patients"International Journal of Cancer. 100. 452-455 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 梅北 善久: "Expression of maspin is up-regulated during the progression of mammary ductal carcinoma"Histopathology. (印刷中). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshihisa Umekita, Yasuyo Ohi, et al.: "Overexpression of CyclinD1 predicts for prognosis in estrogen receptor-negative breast cancer patients"International Journal of Cancer. 98(印刷中). (2002)

    • Related Report
      2001 Annual Research Report

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Published : 2001-04-01   Modified : 2016-04-21  

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