YOSHIKAWA Kazuhiro Associate professor, Department of Pathology, Aichi Medical University, 医学部, 講師 (60109759)
SAGA Shinsuke Professor, Department of Pathology, Aichi Medical University, 医学部, 教授 (40144141)
|Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,400,000 (Direct Cost: ¥2,400,000)
We reviewed 208 clinically suspected malignant lymphoma cases of under sixteen years old. All those clinically suspected cases were histologically evaluated and placed into 2 major groups: i.e., non-Hodgkin lymphoma (NHL, 134 cases) and other diagnosis (63 cases). Other diagnosis group included 12 Hodgkin lymphoma, 12 leukemias, 26 reactive lymphoid hyperplasia, 8 necrotizing histocytic lymphadenitis, and 5 others..
134 NHL cases were classified according to WHO classification; 15 precursor B lymphoblastic lymphoma, 24 diffuse large B-cell lymphoma, 26 Burkitt lymphoma, 30 precursor T lymphoblastic lymphoma, 33 anaplastic large cell lymphoma, 2 peripheral T-cell lymphoma, and 4 other NHLs.
In 5 cases of precursor B lymphoblastic lymphoma and 6 cases precursor T lymphoblastic lymphoma, three chromosomal translocations in pediatric acute lymphoblastic lymphoma, i.e., t(12;21)(p13;q22), t(4;11)(q21;q23), T(9;22)(q34;q11) were examined by FISH and by RT-PCR method. None of those chromosomal translocation or fusion transcripts was detected.
As for prognosis, two patients (one with diffuse large B-cell lymphoma and the other with anaplastic large cell lymphoma) died due to aggressive disease. Prognostic analysis will be continued to determine the prognostic impact of histology, phenotype, clinical stage, and primary sites.