|Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
Prognostic significance of proliferative activity of fibroblasts consisting of a fibrotic focus (FF) in invasive ductal carcinomas (IDCs) of the breast was confirmed by the retrospective analysis. In addition, we prospectively investigated the prognostic significance of a FF in 439 IDC patients, and, clearly demonstrated that the presence of a FF in IDCs is a very important independent prognostic histological predictor of the outcome of IDC patients by multivariate analyses. Especially, IDC patients with a FF of greater than 8 mm in diameter significantly increased the hazard rates (HRs) of tumor recurrence and distant-organ metastasis in multivariate analyses according to their nodal status or hormone receptor status.
The central depressed area CODA) thickness (tumor thickness) of colorectal cancers is an important prognostic parameter for colorectal cancer patients. We 'examined whether the proliferative activities of tumor and stromal components play important roles in tumor thicknes
s increase and the progression of 157 T3 ulcerative-type colorectal cancers. Colorectal cancers were classified into thin and thick groups according to tumor thickness. The tumor-stromal fibroblast proliferative activity was the only parameter significantly associated with tumor thickness. High tumor-stromal fibroblast proliferative activity showed significant correlations with tumor recurrence in the thin group, and high proliferative activity of tumor-stromal endothelial cells was a significant parameter of tumor recurrence in the thick group in multivariate analyses.
IDCs of the breast are composed of stroma-invasive tumors, tumors in lymph vessels and in nodes. We investigated whether the histological characteristics of tumors in vessels and nodes are significantly associated with increased nodal metastases as well as outcomes, in 393 IDO patients. Multivariate analyses showed that, in IDCs without nodal metastasis, FF dimension, and lymph vessel tumor emboli with >6 apoptotic figures and those with a distance from the tumor margin >3 mm had significantly increased the HRs of tumorrecurrence. In IDOs with nodal metastases, apoptotic figures >2 in blood vessel tumors, nodal tumors with mitotic figures >5, those with severe stroma and strand growth, and >5 nodes with extra-nodal invasion significantly increased the HRs of tumor recurrence or death.
These above studies firstly demonstrate that tumor-stromal cells in vessels and lymph nodes as well as in primary-invasive tumors play important roles in tumor progression of breast and colorectal cancers in the world. Less