An epidemiological research on risk factors for post-polio syndrome
| Project/Area Number |
13670399
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | University of Occupational and Environmental Health |
|---|
Principal Investigator |
SAEKI Satoru University of Occupational and Environmental Health, School of Medicine, Associate professor, 医学部, 助教授 (20269070)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HACHISUKA Kenji University of Occupational and Environmental Health, School of Medicine, Professor, 医学部, 教授 (00129602)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
|
|---|
| Keywords | Polio / Post-polio syndrome / Risk factors / Cohort |
|---|
| Research Abstract |
Post-polio syndrome (PPS) is generally defined as a clinical syndrome of new weakness, fatigue and pain in individuals who have previously recovered from acute paralytic poliomyelitis. PPS is occurred 30 or 40 years later acute epidemic of poliomyelitis. Because the last epidemic of acute poliomyelitis in Japan (1960s) occurred 10 years later than in North America (1950s), issues on PPS also appeared approximately 10 years later in Japan. Since the causation of PPS is not clearly known today, the strategy preventing from PPS could targeted the intervention for potential risk factors of PPS. The purpose of this study was to examine the current symptoms related with PPS and identified risk factors of PPS with polio survivors living in Japan. We registered 37 polio survivors (17 men and 20 women; average age of 53 years) in the initial cohort, and did medical examination. They complained the excessive fatigue (81%), muscle weakness (73%), difficulties in climbing stairs up (68%), and so on. Nested case-control study in the subjects (the above cohort) revealed the potential risk factors that have been newly occurred in recent 5 years. The odds ratios (OR) of risk factors significantly associated with PPS were as follows: weight gain (OR 1.30), shortness of breath (OR 1.34), muscular pain (OR 1.45), muscle weakness (OR 1.99) and difficulties in climbing stairs up (OR 1.83). These factors should be detected for intervention at frequent medical check-ups. From the case-series study, particularly at the workplace, PPS individuals need special supports from both rehabilitation medicine and occupational health services, including improved nutrition, achieving ideal body weight, regular and sensible exercise, and modifying working conditions.
|
Report
(3 results)
Research Products
(7 results)
