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The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis

Research Project

Project/Area Number 13670464
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 内科学一般
Research InstitutionKagoshima University

Principal Investigator

MATSUYAMA Takami  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (30145479)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Motoyuki  Kagoshima University, Faculty of Medicine, Research Associate, 医学部, 助手 (30343362)
佐藤 克明  鹿児島大学, 医学部, 講師 (40301147)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordssoluble CD163 / rheumatoid arthritis / hemoglobin / hepatitis / 色素沈着絨毛性滑膜炎 / CD163 / 可溶性 / 慢性関節リウマチ / TIMP
Research Abstract

The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163.
The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsushita N, Matsuyama T et al.: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD 163 in sera and fluids from rheumatoid Arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol.. 130(1). 156-161 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakamura M, Matsuyama T 他: "Nitration and chlorination of folic acid by peroxynitrite and hypochloric acid, and the selective binding of 10-nitro-folate to folate receptor β"Biochem. Biophys.Res.Commun.. 297. 1238-1244 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ijiri K, Matsuyama T 他: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"J. Rheumatology. 29. 2266-2270 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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