| Project/Area Number |
13670525
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | Kochi medical School |
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Principal Investigator |
ONISHI Saburo Kochi medical School, First dept. Med., Professor, 医学部, 教授 (60136380)
|
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji Kochi medical School, First dept. Med., Assistant Professor, 医学部附属病院, 講師 (60145125)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | flowcytometry / aromatase / ArKO / CD25 / CD44 / estrogen / ArKO / thymocyte / auto immunity |
|---|
| Research Abstract |
Thymic regression and reduced cellularity were evident in aromatase-deficient mice. The major difficulties in thymocyte development were observed during the CD44^+CD25^- stage at the cortico-medullary junction and during the CD44^-CD25^- stage at the subcapsular region. The expression of Smoothened of the Hedgehog signaling was enhanced in CD4^-CD8^- double negative cells. This enhancement may result in impaired progression of CD44^-CD25^- cells to the CD4^+CD8^+ double positive stage and impaired proliferation of CD4^+CD8^+ double positive cells. This could be the reason why the proportion of CD3^+TCRβ^<high> cells during the late phase of thymocyte maturation was reduced in ArKO mice.
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