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Roles of cell surface membrane and nuclear prostaglandin receptors in growth factor production during colon carcinogenesis

Research Project

Project/Area Number 13670553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionSaitama Medical School

Principal Investigator

OTA Shinichi  Saitama Medical School, Medicine, Professor, 医学部, 教授 (30185269)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Kenji  Saitama Medical School, Medicine, Professor, 医学部, 教授 (80101088)
ARAI Shin  Saitama Medical School, Medicine, Assistant, 医学部, 助手 (20306294)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordscolon cancer / COX-2 / prostaglandin / VEGF / PPAR / 大腸腺腫 / 受容体 / 血管内皮増殖因子 / PPARγ / マクロファージ
Research Abstract

Various studies have demonstrated that Non-steroidal anti-inflammatory drugs (NSAIDs) prevent colon cancer formation. However, the mechanisms of these steps have not been elucidated yet while cyclooxygenase (COX-2) has been demonstrated to play an important role in this phenomenon. We investigated the localization of COX-2 in human gastric tumors and possible roles using cell lines. What we found was described below: 1. COX-2 was expressed in mesenchymal cells located at sub-epithelial layer of human colonic adenomas. 2. COX-2 was also expressed in mesenchymal cells located at sub-epithelial layer of human hyperplastic gastric polyps but not in human gastric adenomas. 3. Prostaglandin (PG) E induced vascular endothelial growth factor (VEGF) expression by human macrophages through EP_2 and EP_4 prostaglandin receptors. 4. Cicaprost and iloprost, specific ligands for PGI receptors, also stimulated VEGF production by these cells. 5. A PGJ_2 analogue, a specific ligand for PPARγ, but not a PGI_2 analogue, a specific ligand for PPARδ, showed similar effects. 6. Both a ligand for PPARγ and a ligand for PPARδ but not ligands for PGE receptors or PGI receptors simulated VEGF production by colon cancer cell lines. 7. Rebamipide, an anti-ulcer drug, suppressed membrane PG receptor-mediated but not nuclear receptor-mediated increase of VEGF production by macrophages.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Ota S., Bamba H., et al.: "COX-2, prostanoids and colon cancer"Aliment Pharmacol Ther. 16 Suppl 2. 102-106 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S.et al.: "Expression of cyclooxygenase-2 in hyperplastic gastric polyps"J Exp Clin Cancer Res. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S., et al.: "Effect of rebamipide on prostaglandin receptors mediated increase of inflammatory cytokine Production by macrophages"Aliment Pharmacol Ther. (in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S.(分担): "Recent Research developments in Biophysics & Biochemistry"A.Gayathri(in press). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ota, S., Bamba, H., et al.: "COX-2, prostanoids and colon cancer"Aliment Pharmacol Ther. 16 Suppl 2. 102-106 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S. et al.: "Expression of cyclooxygenase-2 in hyperplastic gastric polyps"J Exp Clin Cancer Res. In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S. et al.: "Effect of rebamipide on prostaglandin Receptors mediated increase of inflammatory cytokine production by macrophages"Aliment Pharmacol Ther. In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Bamba H., Ota S. (co-author): "Recent Research developments in Biophysics & Biochemistry"Research SignPost, In press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ota S., Bamba H., et al.: "COX-2, prostanoids and colon cancer"Aliment Pharmacol Ther. 16Suppl2. 102-106 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Bamba H., Ota S.et al.: "Expression of cyclooxygenase-2 in hyperplastic gastric polyps"J Exp Clin Cancer Res. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Bamba H., Ota S., et al.: "Effect of rebamipide on prostaglandin receptors mediated increase of inflammatory cytokine production by macrophages"Aliment Pharmacol Ther. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Bamba H., Ota S.(分担): "Recent Research developments in Biophysics & Biochemistry"A. Gayathri(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Ota, H.Bamba, C Kawamoto, Y Yoshida, K Fujiwara: "COX-2, Prostanoids and Colon Cancer"Alimentary Pharmacology & Therapeutics. (In press).

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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