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Study on the pulmonary microvascular thromboembolism associated with severe influenza virus infection in the elderly

Research Project

Project/Area Number 13670586
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

OHRUI Takashi  Tohoku University Hospital Research Associate, 医学部附属病院, 助手 (90271923)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsInfluenza A virus / older subject / respiratory failure / pulmonary microthromboembolism / D-dimer / oxidative stress / anti-coagulant therapy / exaled CO concentration
Research Abstract

Influenza has been a significant and highly contagious disease of global importance for a long time. We recruited 18 elderly patients (mean age, 78.6, range 69-91 years) with high grade fever (more than 38.5℃) general fatigue and hypoxemia during flu seasons from January 2001 to March 2003 in our university hospital. Among those subjects. 11 patients (7 male) were dignosed as having influenza A (H3N2) virus infection by influenza diagnosing kit. In 5 out of 11 influenza patients, serum D-dimer (mean. 482 ng/ml vs 215 ng/ml) and exaled CO concentrations (mean. 7.2 ppm vs 1.6 ppm) were significantly higher compared with the remained 6 patients, respectively. In 4 out of 5 patients, pulmonary perfusion scan revealed multiple nodular defects in the bilateral lungs (figure). Pulmonary microvascular thromboembolism was diagnosed and three patients who agreed to receive heparin and urokinase therapy survived finally. However, one patient who disagreed to anti-coagulant therapy died with acute severe respiratory fai lure. These results suggest that pulmonary microthromboemboli is an important complication of influenza A virus infection and prompt diagnosis is essential to save the patients from acute death associated with influenza.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Yasuda H: "Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases"Thorax. 57. 779-783 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsui T: "Sitting position to prevent aspiration in bed-ridden patients"Gerontology. 48. 194-195 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoneyama T: "Oral care reduces pneumonia of elderly patients in nursing homes"J Am Geriatr Soc. 50. 430-433 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohrui T: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax. 57. 561 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaya M: "Prevention of respiratory infections in the elderly (Review)"Geriatr Gerontol Internat. 2. 115-121 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Wang HD: "Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats"Am J Respir Crit Care Med. 165. 406-411 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasuda H: "Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases"Thorax.. 57. 779-783 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsui T: "Sitting position to prevent aspiration in bed-ridden patients"Gerontology.. 48. 194-195 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoneyama T: "Oral care reduces pneumonia of elderly patients in nursing homes"J Am Geriatr Soc.. 50. 430-433 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohrui T: "Relationship between asthma severity and progression of Alzheimer' s disease"Thorax.. 57. 561 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yamaya M: "Prevention of respiratory infections in the elderly (Review)"Geriatr Gerontol Internat.. 2. 115-121 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Wang HD: "Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats"Am J Respir Crit Care Med.. 165. 406-411 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yasuda H: "Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases"Thorax. 57. 779-783 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsui T: "Sitting position to prevent aspiration in bed-ridden patients"Gerontology. 48. 194-195 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoneyama T: "Oral care reduces pneumonia of elderly patients in nursing homes"J Am Geriatr Soc. 50. 430-433 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohrui T: "Relationship between asthma severity and progression of Alzheimer's disease"Thorax. 57. 561 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamaya M: "Prevention of respiratory infections in the elderly (Review)"Geriatr Gerontol Internat. 2. 115-121 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wang HD: "Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats"Am J Respir Grit Care Med. 165. 406-411 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamaya M: "Interventions to prevent pneumonia among older adults"J Am Geriatr Soc. 49. 85-90 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohrui T: "A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia?"Tohoku J Exp Med. 193. 245-249 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamaya M: "Antithrombotic therapy for prevention of pneumonia"J Am Geriatr Soc. 49. 687-688 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Wada H: "Risk factors of aspiration pneumonia in Alzheimer's disease patients"Gerontology. 47. 271-276 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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