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Analysis oftarget anfigens in oerebrospinal oligoclonal bands in multiple sclerosis patients

Research Project

Project/Area Number 13670626
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

FUJIHARA Kazuo  Tohoku University Hospital, Associate Professor, 医学部附属病院, 助教授 (70280873)

Co-Investigator(Kenkyū-buntansha) ONODERA Hiroshi  Tohoku University Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (20214207)
ITOYAMA Yasuto  Tohoku University Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (30136428)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsdemyelinating disease / neuroimmunology / neurologic intractable diseasa / multiple sclerosis / oligoclonal band
Research Abstract

Cerebrospinal fluid (CSF) oligoclonal lgG band (OS) is an important laboratory finding in multiple sclerosis (MS). Since its clinical implication and target antigens remain to be elucidated, we conducted the following analyses. We applied the sensitive isoelectric focusing (IEF) method to detect OB in MS and found that the frequencies of OB were 67.9% in conventional MS (CMS) and 10% in optic-spinal MS (OSMS). Interestingly, the brain MRI findings in OB-negative CMS patients were often atypical. We studied the CSF lgG epitopes with the phage display method. Common aminoacid sequences were detected in each case, and they were frequently homogenous to herpes viral proteins. However, those sequences in each patient were unique. We analyzed the 3 CSF samples of an OB-positive patient and consistently detected the identical sequences homologous to EB viral proteins. Among them, the sequence homologous to EB viral ZEBRA protein reacted more to CSF than serum in VVestern blot, suggesting the relevance to OB. The GST fusion proteins were synthesized, and the CSF lgG reacted to the fusion protein were precipitated in the GST pull down assay. After the absorption, the CSF was subjected to IEF, but the banding pattern of OB was unchanged. Therefore, each band of OB probably consists of multiple antibodies. The viral IL-1O was not detected in any CSF sample obtained during relapse. Some patients have linear trigeminal root lesions, and these unique lesions are similar to those caused by herpes simplex viral infection in animals. The CSF antibody titers to herpes virus were elevated in one OB-positive patient with such lesion during relapse. Our study demonstrated the pathogenetic significance of OB in MS. The peptide sequences shown to react to CSF lgG in MS in the present study may be an important information to further analyze the target antigens of OB.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (112 results)

All Other

All Publications (112 results)

  • [Publications] Nakashima I: "Linear trigeminal root lesions in multiple sclerosis -clinical and MRI study in five cases-"Arch Neurol. 58. 101-104 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Chemokine receptor expression on T-cells in blood and cerebrospinal fluid at relapse and emission of multiple sclerosis : Imbalance of Th1/Th2-associated chemokine signaling"J Neuroimmunol. 114. 207-212 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimizu H: "Clinical and physiological significance of abnormally prolonged central motor conduction time in HAM/TSP"J Neurol Sci. 185. 39-42 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Linear pontine and trigeminal root lesions and trigeminal neuralgia"Arch Neurol. 58. 1311-1312 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazawa I: "Eugene Devic (1858-1930)"J Neurol. 249. 351-352 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Pure optic-spinal form of multiple sclerosis in Japan"Brain. 125. 2460-2468 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "A comparative study of Japanese patients with and without oligoclonal IgG bands"Mult Scler. 8. 459-462 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hayashi T: "Inflammatory demyelinating disease mimicking malignant glioma"J Nucl Med. 44. 565-569 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto Y: "CDR3 spectratyping analysis of the T cell receptor repertoire in multiple sclerosis"J Immunol. 170. 4846-4853 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 松崎理子: "若年性腎血管性高血圧に合併した横断性脊髄症の1例"脳と神経. 53. 859-862 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 糸山泰人: "多発性硬化症の治療戦略"臨床神経学. 41. 1214-1217 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤 滋: "脱髄疾患 疾患と薬物療法"Clinical Neuroscience. 19. 166-168 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤 滋: "多発性硬化症の免疫学的研究"脊髄脊椎ジャーナル. 14. 201-204 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 三須建郎: "横断性脊髄炎"Clinical Neuroscience. 19. 788-791 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 糸山泰人: "多発性硬化症の治療"Current Insight in Neurological Science. 9. 2-4 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中島一郎: "ANCA関連脊髄炎"脊髄脊椎ジャーナル. 14. 432-435 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 宮澤イザベル: "Neuromyelitis optica(Devic病)と視神経脊髄型MS"脳と神経. 53. 901-910 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中島一郎: "視神経脊髄型MSの疫学と臨床"脳と神経. 53. 911-917 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 糸山泰人: "多発性硬化症 病因・病態研究の進歩と新たな治療"脳と神経. 54. 5-21 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 糸山泰人: "内科100年のあゆみ 多発性硬化症"日本内科学会雑誌. 91. 2339-2343 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "Neuromyelitis optica原典とその今日的意義"神経内科. 56. 306-311 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中島一郎: "多発性硬化症(特集 急性期神経疾患への一般内科的対応)"Mebio. 19. 27-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原 一男: "多発性硬化症の免疫学的治療の問題点と戦略"神経免疫学. 10. 221-226 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "ミエロパチー(シェーグレン症侯群、サルコイドーシス、全身性エリテマトーデス"脊椎脊髄ジヤーナル. 16. 585-587 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "QOLを重視した多発性硬化症患者の治療"神経治療学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "視神経脊髄型MSと免疫病態"臨床神経学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "多発性硬化症のインターフェロンβ療法"Current Insights in Neurological Science. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "多発性硬化症の臨床病型と免疫病態"日本臨床. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 三須建郎, 藤原一男, 糸山泰人: "多発性硬化症 ケモカイン・ケモカイン受容体の解析"日本臨床. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Pure neuromyelitis optica : a clinical, MRI, and immunological study in 10 Japanese patients"Neurology. 56(suppl3). A196-A196 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Clinical features of Japanese multiple sclerosis patients without oligoclonal IgG bands"Neurology. 56(suppl3). A197-A197 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujimori J: "The epitope analysis of CSF oligoclonal IgG in Japanese MS patients by phage display method"Neurology. 56(suppl3). A225-A225 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "The association between oligoconal IgG bands and corpus callosal lesions in Japanese multiple sclerosis patients"Neurology. 58(suppl3). A71-A71 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "CCR7-positive antigen presenting cells and central memory T cells in CNS of multiple sclerosis"Neurology. 58(suppl3). A304-A304 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujimori J: "Epitope analysis of cerebrospinal fluid IgG in HTLV-I-associated myelopathy patients using phage display method"Neurology. 58(suppl3). A306-A306 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Feng J: "Immunological and virological effects of interferon-α therapy in HTLV-I associated myelopathy/tropical spastic paraparesis"Ann Neurol. 52(suppl1). S72-S72 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 黒田 宙: "神経内科 検査・処置マニュアル"新興医学出版社. 5 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 藤原一男: "ダイナミック神経診断学"西村書店. 9 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Linear trigeminal root lesions in multiple sclerosis -clinical and MRI study in five cases-"Arch Neurol. 58. 101-104 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Chemokine receptor expression on T-cells in blood and cerebrospinal fluid at relapse and emission of multiple sclerosis: Imbalance of Th1/Th2-associated chemokine signaling"J Neuroimmunol. 114. 207-212 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimizu H: "Clinical and physiological signiflcance of abnormally prolonged central motor conduction time in HAM/TSP"J Neurol Sci. 185. 39-42 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Linear pontine and trigeminal root lesions and trigeminal neuralgia"Arch Neurol. 58. 1311-1312 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazawa I: "Eugene Devic (1858-1930)"J Neurol. 249. 351-352 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Pure optic-spinal form of multiple sclerosis in Japan"Brain. 125. 2460-2468 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "A comparative study of Japanese patients with and without oligoclonal IgG bands"Mult Scler. 8. 459-462 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hayashi T: "Inflammatory demyelinating disease mimicking mallgnant glioma"J Nucl Med. 44. 565-569 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsumoto Y: "CDR3 spectratyping analysis of the T cell receptor repertoire in multiple scierosis"J Immunol. 170. 4846-4853 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsuzaki M: "Transverse myelopathy with renovascular hypertension caused by fibromascular dysplasia"Brain and Nerve (No to Shinkei). 53. 859-862 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itoyama Y: "Therapeutic strategy of multiple sclerosis"Clin Neurol (Rinshoushinkeigaku). 41. 1214-1217 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato S: "Demyelinating disease -disease and drug therapy-"Clinical Neuroscience. 19. 166-168 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato S: "Immunological study or multiple sclerosis"Spine and spinal cord. 14. 201-204 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Transverse myelitis"Clinical Neuroscience. 19. 788-791 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itoyama Y: "Therapy of multiple sclerosis"Current Insight in Neurological Science. 9. 2-4 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "ANCA associated myelitis"Spine and spinal cord. 14. 432-435 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Miyazawa I: "Neuromyelitis optica (Devic's disease) and optic-spinal form multiple sclerosis"Brain and Nerve (No to Shinkei). 53. 901-910 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Epidemiology and clinical features of opitc-spinal form multiple sclerosis in Japan"Brain and Nerve (No to Shinkei). 53. 911-917 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itoyama Y: "Multiple sclerosis -recent advances in pathogenesis and treatment-"Brain and Nerve (No to Shinkei). 54. 5-21 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Itoyama Y: "Multiple sclerosis"J Jpn Soc intern Med. 91. 2339-2343 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Neuromyelitis optica (Devic's disease) -its original and the implication"Neurological medicine (Shinkeinalka). 56. 306-311 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Multiple sclerosis"Mebio. 19. 27-33 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Issues and strategies in immunological therapies of multiple sclerosis"Neuroimmunology. 10. 221-226 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Myelopathy in Sjogren syndrome, sarcoidosis and systemic lupus erythematosus"Spine and spinal cord. 16. 585-587 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Therapy and quality of life in multiple sclerosis"Neurological therapeutics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Opitc-spinal multiple sclerosis and the immunopathogenesis"Clin Neurol (Rinshoushinkeigaku). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Interferon-β therapy in multiple sclerosis"Current Insights in Neurological Science. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Clinical subtypes of multiple sclerosis and the immuno-pathogeneses"Nihonrinsho. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Multiple sclerosis -analysis ofchemokines and chemokine receptors-"Nihonrinsho. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Pure neuromyelitis optica: a clinical, MRI, and immunological study in 10 Japanese patients"Neurology. 56(Suppl 3). A196 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "Clinnical features of Japanese multiple sclerosis patients without oligoclonal IgG bands"Neurology. 56(Suppl 3). A197 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujimori J: "The epitope analysis of CSF oligoclonal IgG in Japanese MS patients by phage display method"Neurology. 56(Suppl 3). A225 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakashima I: "The association between oligoconal IgG bands and corpus callosal lesions in Japanese multiple sclerosis patients"Neurology. 58(Suppl 3). A71 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "CCR7 -positive antigen presenting cells and central memory T cells in CNS of multiple sclerosis"Neurology. 58(Suppl 3). A304 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujimori J: "Epitope analysis of cerebrospinal fluid IgG in HTLV-I-associated myelopathy patients using phase display method"Neurology. 58(Suppl 3). A306 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Feng J: "Immunological and virological effects of interferon-α therapy in HTLV-I associated myelopathy tropical spastic paraparesis"Ann Neurol. 52(Suppl 1). S72 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kuroda S: "Shinkoigaku Publishing Co."Plasmapheresis in Neurology-Laboratory and Procedure Manual-. 5 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fujihara K: "Mishimura Shoten"immunological diagnostic methods in Dynamic Neurological Diagnosis. 9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Misu T: "Pure optic-spinal form of multiple sclerosis in Japan"Brain. 125. 2460-2468 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakashima I: "A comparative study of Japanese patients with and without oligoclonal IgG bands"Mult Scler. 8. 459-462 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hayashi T: "Inflammatory demyelinating disease mimicking malignant glioma"J Nucl Med. (in press). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsumoto Y: "CDR3 spectratyping analysis of the T cell receptor repertoire in multiple sclerosis"J Immunol. (in press). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Miyazawa I: "Eugene Devic (1858-1930)"J Neurol. 249. 351-352 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakashima I: "The association between oligoconal IgG bands and corpus callosal lesions in Japanese multiple sclerosis patients"Neurology. 58(suppl3). A71-A71 (2002)

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  • [Publications] Misu T: "CCR7-positive antigen presenting cells and central memory T cells in CNS of multiple sclerosis"Neurology. 58(suppl3). A304-A304 (2002)

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  • [Publications] 糸山泰人: "多発性硬化症 病因・病態研究の進歩と新たな治療"脳と神経. 54. 5-21 (2002)

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  • [Publications] 藤原一男: "Neuromyelitis optica 原典とその今日的意義"神経内科. 56. 306-311 (2002)

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  • [Publications] 中島一郎: "多発性硬化症(特集 急性期神経疾患への一般内科的対応)"Mebio. 19. 27-33 (2002)

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  • [Publications] 藤原一男: "多発性硬化症の免疫学的治療の問題点と戦略"神経免疫学. 10. 221-226 (2002)

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  • [Publications] 糸山泰人: "多発性硬化症の治療"日内会誌. 91. 2339-2343 (2002)

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  • [Publications] 藤原一男: "視神経脊髄型MSと免疫病態"臨床神経学. (印刷中).

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  • [Publications] 藤原一男: "QOLを重視した多発性硬化症患者の治療"神経治療学. (印刷中).

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  • [Publications] Nakashima I: "Linear trigeminal root lesions in multiple sclerosis clinical and MRI study in five cases"Arch Neurol. 58. 101-104 (2001)

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  • [Publications] Misu T: "Chemokine receptor expression on T-cells in blood and cerebrospinal fluid at relapse and emission of multiple sclerosis : lmbalance of Th1/Th2-associated chemokine signaling"J Neuroimmunol. 114. 207-212 (2001)

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  • [Publications] Shimizu H: "Clinical and physiological significance of abnormally prolonged central motor conduction time in HAM/TSP"J Neurol Sci,. 185. 39-42 (2001)

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  • [Publications] Nagata T: "Decreased expression of c-myc family genes in thymuses from myasthenia qravis patients"J Neuroimmunol,. 115. 199-202 (2001)

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  • [Publications] Oyaizu T: "Lambert-Eaton myasthenic syndrome associated with an anterior mediastinal small cell carcinoma"J Thorac Cardiovasc Surg. 121. 1005-1006 (2001)

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  • [Publications] Tateyama M: "Expression of OX40 in muscles of polymyositis and granulomatous myopathy"J Neurol Sci. 194. 29-34 (2001)

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  • [Publications] 佐藤 滋: "脱髄疾患 疾患と薬物療法"Clinical Neuroscience. 19. 166-168 (2001)

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  • [Publications] 佐藤 滋: "多発性硬化症の免疫学的研究"脊髄脊椎ジャーナル. 14. 201-204 (2001)

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  • [Publications] 三須建郎: "横断性脊髄炎"Clinical Neuroscience. 19. 788-791 (2001)

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  • [Publications] 糸山泰人: "多発性硬化症の治療"Current Insight in Neurological Science. 9. 2-4 (2001)

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  • [Publications] 中島一郎: "ANCA関連脊髄炎"脊髄脊椎ジャーナル. 14. 432-435 (2001)

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  • [Publications] 宮澤イザベル: "Neuromyelitis optica (Devic病)と視神経脊髄型MS"脳と神経. 53. 901-910 (2001)

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  • [Publications] Nakashima I: "A comparative study of Japanese patients with and without oligoclonal lgG bands"Mult Scler. (in press).

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  • [Publications] Miyazawa I: "Eugene Devic (1858-1930)"J Neurol. (in press).

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  • [Publications] Nakashima I: "Linear pontine and trigeminal root lesions and trigeminal neuralgia"Arch Neurol. 58. 1311-1312 (2001)

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  • [Publications] Misu T: "Pure neuromyelitis optica : a clinical, MRI, and immunological study in 10 Japanese patients"Neurology. 56(Suppl 3). A196 (2001)

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  • [Publications] Fujimori J: "The epitope analysis of CSF oligoclonal lgG in Japanese MS patients by phage display method"Neurology. 56(Suppl 3). A225 (2001)

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  • [Publications] 松崎理子: "若年性腎血管性搆血圧に合併した横断性脊髄症の1例"脳と神経. 53. 859-862 (2001)

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  • [Publications] 中島一郎: "視神経脊髄型MSの疫学と臨床"脳と神経. 53. 911-917 (2001)

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  • [Publications] 糸山泰人: "多発性硬化症 病因・病態研究の進歩と新たな治療"脳と神経. 54. 5-21 (2002)

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  • [Publications] 黒田 宙: "神経内科 検査・処置マニュアル"新興医学出版社. 5 (2001)

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  • [Publications] 藤原一男: "ダイナミック神経診断学"西村書店. 9 (2001)

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Published: 2001-04-01   Modified: 2016-04-21  

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