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Identification of endothelium-derived hyperpolarizing factor (EDHF) in human arteries.

Research Project

Project/Area Number 13670724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyushu University

Principal Investigator

HIRAKAWA Yoji  Kyushu Univ, Dept of CV Med, Assist Prof, Hospital, 医学部附属病院, 助手 (90332840)

Co-Investigator(Kenkyū-buntansha) SHIMOKAWA Hiroaki  Kyushu Univ, Dept of CV Med, Assoc Prof., 大学院・医学研究院, 助教授 (00235681)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsEDHF / Vascular endothelial cells / EDRFs / Hydrogen peroxide / 内皮依存性過分極因子 / ブラジキニン / カタラーゼ / ギャップジャンクション
Research Abstract

We have recently identified that endothelium-derived hydrogen peroxide (H202) is an endothelium-derived hyperpolarizing factor (EDHF) in mice (Journal of Clinical Investigation, 2002). In this series of experiments, we have examined whether H202 is also and EDHF in human arteries.
In isolated human mesenteric arteries, EDHF-mediated responses were inhibited by catalase that specifically decomposes H202 into water and oxygen. Exopgenous H202 also exerted relaxations and hyperpolarizations of vascular smooth muscle. By contrast, we were unable to confirm other hypotheses on the nature of EDHF, including epoxyeicosatrienoic acids (EETs), K ion, and gap junctions.
These results indicate that H202 is also an EDHF in human mesenteric arteries.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Matoba T, et al.: "Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries"Biophys Biochem Res Comm.. 290. 909-913 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yada T, et al.: "Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase"Circulation. 107. 1040-1045 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matoba T, et al,: "Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries."Biophyc Biochem Res Commun.. 290. 909-913 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yada T, Shimokawa H, et al.: "Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase."Circulation.. 107. 1040-1045 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matoba T, et al.: "Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries"Biophys Biochem Res Comm.. 2002. 909-913 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yada T, et al.: "Hydrogen peroxide, an endogenous EDHF, plays an important role in coronary autoregulation in vivo"Circulation. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tetsuya Matoba: "Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries"Biochemical and Biophysical Research Communication. 290. 909-913 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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