Identification of break point genes of leukemia with t(1 ; 22)(p13 ; q13)
| Project/Area Number |
13670810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
ASOU Hiroya Research Institute for Radiation Biology and Medicine Research Associate, 原爆放射線医科学研究所, 助手 (60243614)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | leukemia / t(1 ; 22)(p13 ; q13) / t(1;22)(p13;q13) / 融合遺伝子 |
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| Research Abstract |
1) A human megakaryoblastic leukemia cell line with t(1 ; 22)((p13 ; q22), HIS was established.
2) HIS cell line expressed OTT-MAL fusion gene.
3) Growth of HIS cells were suppressed by antisense DNA of OTT-MAL fusion gene.
4) RBM15-MKL1 fusion gene was detected by RTPCR in samples from infant acute megakaryoblastic leukemia.
5) A human myeloid leukemia cell line, Kasumi-6 with mutated C/EBP alpha gene was established.
6) Expression vector either OTT, MAL, or OTT-MAL gene were made.
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Report
(3 results)
Research Products
(10 results)
