| Project/Area Number |
13670953
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | 宮崎医科大学 |
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Principal Investigator |
YANO Takanori (2002-2003) MIYAZAKI UNIVERSITY, MEDICAL COLLEGE, ASSISTANT PROFESSOR, 医学部, 助手 (20315378)
陣之内 正史 (2001) 宮崎医科大学, 医学部, 助教授 (60154423)
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| Co-Investigator(Kenkyū-buntansha) |
UNO Takeshi MIYAZAKI UNIVERSITY, MEDICAL COLLEGE, ASSOCIATE PROFESSOR, 医学部, 助教授 (70038842)
KODAMA Takao MIYAZAKI UNIVERSITY, MEDICAL COLLEGE, ASSOCIATE PROFESSOR, 医学部, 助教授 (40153564)
NAGAMACHI Shigeki MIYAZAKI UNIVERSITY, MEDICAL COLLEGE, ASSOCIATE PROFESSOR, 医学部, 助教授 (40180517)
菅 涼子 宮崎医科大学, 医学部, 助手 (60325751)
矢野 貴徳 宮崎医科大学, 医学部, 助手 (20315378)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Chronic pain / rCBF SPECT / Spinal Cord Stimulation / SPM analysis / 3DSSP analysis / 脳血流 / 硬膜外脊髄通電 / SPM / 治療効果 / 局所脳血流 / リドカイン |
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| Research Abstract |
The purpose of the present study was to objectively review the pathological condition of chronic pain and evaluate the efficacy of SPECT cerebral blood flow analysis and statistic image analysis in judgment of outcome of SCS treatment. A total of 14 patients with chronic pain underwent Tc-99m-HMPAO SPECT cerebral blood flow analysis before and after SCS treatment. 3D-SSP was adopted to evaluate the reproduced images. The normal controls were 15 individuals who underwent MRI and were told that no organic abnormalities were noted. Nine patients responded favorably to SCS treatment, while five responded poorly to this treatment. We used the data obtained from the patients to make the following comparisons : (1)comparison between the baseline cerebral blood flow distribution in the patient group and the data obtained from the normal control group, (2)comparison between the posttreatment cerebral blood flow distribution in the effective group and the data obtained from the normal control gr
… More
oup and that between the posttreatment cerebral blood flow distribution in the ineffective group and the data obtained from the normal control group and (3)comparison between the pretreatment and posttreatment cerebral blood flow distribution in the effective group and that between the pretreatment and post-treatment data in the ineffective group. (1)According to the baseline data, the blood flow in the prefrontal region, anterior cingulate cortex and secondary somatosensory cortex (SII) either decreased or increased. (2)After SCS treatment, the regions showing decreased blood flow were examined and the statistical pixel-by-pixel summation scores (Z scores) of the prefrontal region, SII and anterior cingulate cortex were decreased in the effective group. In the ineffective group, the regions showing decreased blood flow were also examined and Z scores of the prefrontal region, SII and anterior cingulate cortex were increased. (3)The significant changes in regional cerebral blood flow distribution were observed in the effective group, while only slight changes were recognized in the ineffective group.Tc-99m-HMPAO SPECT analysis and 3D-SSPs seemed to be effective in objectively evaluating the severity and improvement of pain in the patients with chronic pain. Less
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