• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of the mechanisms of the persistence seizure susceptibility acquired in the developing periods in amygdaloid kindled rats

Research Project

Project/Area Number 13671005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTottori University

Principal Investigator

YOSHIOKA Shin-ichi  Tottori University, Faculty of Medicine Associate professor, 医学部, 助教授 (00191544)

Co-Investigator(Kenkyū-buntansha) IMOTO Toshiaki  Tottori University, Faculty of Medicine Associate professor, 医学部, 助教授 (10109639)
YOSIOKA Shin-ichi  Tottori University, Faculty of Medicine Associate professor (00191544)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsamygdaloid kindling / seizure susceptibility / epileptogenesis / monosodium glutamate / methotrexate / immature / re-kindling / rat
Research Abstract

We investigated whether the primary and secondary epileptogenesis acquired in developing periods persists into adulthood using amygdaloid kindling rats. When the initial kindling was established at age 40 and 70 days, the number of stimulations required to induce the first stage 5 seizure at the contralateral as well as ipsilateral sites was significantly fewer in kindled rats than in non-stimulated controls. When the initial kindling was established at age 14 days the number of stimulations required to induce the first stage 5 seizure at neither ipsilateral or contralateral site in kindled rats was not significantly different from that in non-stimulated controls. When the initial kindling was established at age 28 days, the facilitative effect was observed at the ipsilateral site, but not at the contralateral site. These results suggest that both the primary and secondary epileptogenesis acquired at age 14 days is diminished after maturation, and the persistence of seizure susceptibility acquired in the developing periods is weaker in the primary than secondary site.
To clarify the mechanisms of the persistence of seizure susceptibility, we (MTX) treatments in rats modify the development of amygdaloid kindling in immature period and the persistence of seizure susceptibility during development. Both MSG and MTX treatments decreased significantly the number of stimulations required to reach the first stage 5 seizure in pups at age 14 days. When the rats were rekindled at age 70 days, the number of stimulations required to reinduce the first stage 5 seizure was significantly lower in rats treated with both MSG and MTX than that in control rats. These results suggest that the susceptibility to kindling-induced seizure in immature rats is enhanced with both MSG and MTX treatments, and that the enhanced seizure susceptibility acquired in immature period persists into maturity.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] S-I, Yoshioka: "Development of amygdaloid kindling in rats treated neonatally with monosodium glutamate"Epilepsia. 42(Suppl.2). 128-129 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉岡伸一: "発達期のラット扁桃核キンドリングに及ぼす新生仔期グルタミン酸投与の影響"てんかん研究. 20. 78 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shin-ichi Yoshioka: "Maturational changes of primary and secondary epileptogenesis acquired in developing periods in rats"Epilepsia. 43(Suppl.8). 82 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shin-ichi,Yoshioka.: "Development of amygdaloid kindling in rats treated neonatally with monosodium glutamate"Epilepsia. 42 (Suppl.2). 128-129 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shin-ichi,Yoshioka.: "Effects of neonatal treatment of glutamate on the development of amygdaloid kidling in developing rats"J. Jpn. Epil. Soc.. 20. 78 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shin-ichi,Yoshioka.: "Maturational changes of primary and secondary epileptogenesis acquired in developing periods in rats"Epilepsia. 43(Suppl.8). 82 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S-I, Yoshioka: "Development of amygdaloid kindling in rats treated neonatally with monosodium glutamate"Epilepsia. 42(Suppl.2). 128-129 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 吉岡伸一: "発達期のラット扁桃核キンドリングに及ぼす新生仔期グルタミン酸投与の影響"てんかん研究. 20・1. 78 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shin-ichi Yoshioka: "Maturational changes of primary and secondary epileptogenesis acquired in developing periods in rats"Epilepsia. 43(Suppl.8). 82 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S-I.Yoshioka: "Development of amygdaloid kindling in rats treated with monosodium glutamate"Epilepsia. 42(Suppl.2). 128-129 (2001)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi