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Polymorphism screening and association analysis of neurotrophic factor genes in neuropsychiatric diseases

Research Project

Project/Area Number 13671034
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry (2002)
Teikyo University (2001)

Principal Investigator

KUNUGI Hiroshi  Head, Department of Mental Disorder Research, National Center of Neurology and Psychiatry, 疾病研究第三部, 部長 (40234471)

Co-Investigator(Kenkyū-buntansha) NANKO Shinichiro  Professor, Department of Psychiatry, Teikyo University School of Medicine, 医学部, 教授 (60101127)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsneurotrophic factor / VGF / p75 / neurotrophin-3 / schizophrenia / Alzheimer's disease / polymorphism / association study / ニューロトロフィン-3 / 精神分裂病 / 一塩基多型(SNP)
Research Abstract

Based on the neurodevelopmental hypothesis in the etiology of schizophrenia, neurotrophic factors (NTFs) maybe involved in the pathogenesis of the illness. NTFs are also implicated in the pathogenesis of neurodegenerative diseases. We searched for polymorphisms for genes encoding brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), their low affinity receptor p75, and vgf, which is induced by neurotrophins during development and differentiation of the central nervous system. Detected polymorphisms were subject to association analyses with neuropsychiatric diseases. We found that a particular haplotype (G[[-3004]-A3] in the NT-3 gene was significantly associated with schizophrenia (p=0.005), suggesting that this haplotype gives susceptibility to schizophrenia. Using direct sequencing, we found two single nucleotide polymorphisms (SNPs) in the p75 gene, one of which results in an amino-acid change. When this polymorphism was examined for the possible association with schizophrenia and Alzheimer's disease, however, there was no significant difference in the genotype or allele distribution between patients and controls. With respect to the vgf gene, we found several differential sequences from those sequences that were previously published. However, we obtained no evidence for the presence of polymorphisms in our sample, suggesting that DNA sequence of the vgf gene is highly conserved. Further investigations on the possible role of the NT-3 gene in the pathogenesis of schizophrenia are warranted.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 功刀 浩 ほか: "神経栄養因子遺伝子と精神神経疾患:VGF遺伝子の変異解析"精神薬療研究年報. 34. 29-33 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akahane A ほか: "Association analysis of polymorphic CGG repeats in 5'UTR of the reelin and VLDLR genes with schizophrenia"Schizophrenia Research. 58. 37-41 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kunugi H ほか: "Polymorphism screening of the neurotrophin receptor p75 gene and association analysis with schizophrenia"American Journal of Medical Genetics. 114. 855 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hattori M ほか: "Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia"American Journal of Medical Genetics. 114. 304-309 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kunugi H ほか: "Brain derived neurotrophic factor gene and schizophrenia : polymorphism screening and association analysis"Schizophrenia Research. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hattori M, Kunugi H, Akahane A, Tanaka H, Ishida S, Hirose T, Morita R, Yamakawa K, Nanko S: "Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia"American Journal of Medical Genetics. 114 (3). 304-309 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Akahane A, Kunugi H, Tanaka H, Nanko S: "Association analysis of polymorphic CGG repeats in 5' UTR of the reelin and VLDLR genes with schizophrenia"Schizophrenia Research. 58 (1). 37-41 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kunugi H, Nanko S: "Polymorphism screening of the neurotrophin receptor p75 gene and association analysis with schizophrenia"American Journal of Medical Genetics. 114 (7). 855 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kunugi H, Akahane A, Tanaka H, Nanko S: "Polymorphism analysis on the vgf gene in neuropsychiatric diseases"Annual Report of Pharmacopsychiatry Research. 34. 29-33 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kunugi H, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: "Brain derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis"Schizophrenia Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hattori M. 他: "Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia"Am. J. Med. Genet.. 114. 304-309 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akahane A. 他: "Association analysis of polymorphic CGG repeats in 5' UTR of the reelin and VLDLR genes with schizophrenia"Schizopjr. Res.. 58. 37-41 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kunugi H. 他: "Polymorphism screening of the neurotrophin receptor p75 gene and association analysis with schizophrenia"Am. J. Med. Genet.. 114. 855 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 功刀浩 他: "神経栄養因子と精神神経疾患:VGF遺伝子の変異解析"精神薬療研究年報. 34. 29-33 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kunugi H. 他: "Brain derived neurotrophic factor gene and schizophrenia : polymorphism screening and association analysis"Schizopjr. Res.. (印刷中).

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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