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A SPECT study for evaluation of treatment efficacy in dementia of the Alzheimer's type

Research Project

Project/Area Number 13671038
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKansai Medical University

Principal Investigator

NOBUHARA Kenji  Kansai Medical University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (90247932)

Co-Investigator(Kenkyū-buntansha) KINOSHITA Toshihiko  Kansai Medical University, Faculty of Medicine, Professor, 医学部, 教授 (20186290)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsAlzheimer Disease / SPECT / rCBF / Donepezil
Research Abstract

The purpose of this study is to investigate the relation between the clinical efficacy and the changes of regional cerebral blood flow(rCBF) in the early stage of Alzheimer's disease(AD) patients after treatment of Donepezil Hydrochloride(DH). The subjects were seven outpatients. They were diagnosed to have AD on criteria of DSM-IV and NINCDS-ADRDA. The cognitive functions were estimated by ADAS-Jcog. A three-headed gamma-camera system(Toshiba GCA-9300A/DI) was used. In each measurement, 111 MBq[123I]-IMP was injected intravenously. The reconstruction was made with 64×64 matrix. CBF was calculated on a voxel-by-voxel basis using the ARG method. In five of seven patients(the responders to DH) * scores of ADAS-Jcog were improved within three months after treatment of DH therapy. On the other hand, the two patients(the non-responder to DH therapy) had no significant changes. The responder showed increase of CBF in whole brain with more than 10% than baseline within three months after treatment. In this group, marked per fusion increase was found in basal ganglia. The non-responder showed reduction of CBF in whole brain with 10% more than baseline. SPECT is promising tool with which to assess the impact of DH therapy on brain functioning of AD patients.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 吉田常孝: "初期アルツハイマー病の123I-IMP ARG法を用いた脳血流SPECT塩酸ドネペジルによる治療効果予測の可能性について"核医学. 38. 777 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kenji Nobuhara: "SPECT imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQNP"European Journal of Nuclear Medicine. 28. 13-24 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 吉村匡史: "アルツハイマー病の脳電場動態解析による検討"臨床脳波. 44. 707-710 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 延原健二: "晩発生アルツハイマー病患者における薬物治療効果判定に関するSPECT研究"Intervision. 18. 57 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masafumi Yoshimura: "Global Approach to Multi-channel EEG Analysis for Diagnosis and Clinical Evaluation in Mild Alzheimer's Disease."Neuropsychobiology. 49. 163-166 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 吉田常孝: "アルツハイマー病の123I-IMP ARG法を用いた脳血流SPECTと治療効果予測の可能性について"臨床放射線. 48. 306-310 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tunetaka Yoshida: "Recent Advances in Human Brain Mapping. International Congress Series 1232"Koichi Hirata, Yoshihiko Koga, Ken Nagata, Kaoru Yamazaki, Elsevier. 934 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tunetaka Yoshida: "[^<123>I]-IMP SPECT study for prediction of efficacy of Donepezil treatment in early stage of Alzheimer's disease."Kaku Igaku. 38. 777 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kenji Nobuhara: "SPECT imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQN"European Journal of Nuclear Medicine. 28. 13-24 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masafumi Yoshimura: "Spatial EEG dynamics of Alzheimer's disease."Rinsho Nouha. 44. 707-710 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tunetaka Yoshida: "[^<123>I]-IMP brain per fusion SPECT in Alzheimer's disease related to clinical efficacy of Donepezil."Japanese Journal of Clinical Radiology. 48. 306-310 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kenji Nobuhara: "A SPECT study for prediction of treatment response in Alzheimer's disease."Intervision. 18. 57 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Masafumi Yoshimura: "Global Approach to Multi-channel EEG Analysis for Diagnosis and Clinical Evaluation in Mild Alzheimer's Disease."Neuropsychobiology. 49. 163-166 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 吉村匡史: "軽症アルツハイマー病患者における脳電場構造の評価"臨床神経生理学. 31. 203 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 吉田常孝: "アルツハイマー病の123I-IMP ARG法を用いた脳血流SPECTと治療効果予測の可能性について"臨床放射線. 48・2. 306-310 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 延原健二: "晩発性アルツハイマー病患者における薬物治療効果判定に関するSPECT研究"Intervision. 18・8. 57 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tunetaka Yoshida: "Recent Advances in Human Brain Mapping"koichi Hirata, Yoshihiko Koga, Ken Nagata and Kaoru Yamazaki, Elsevier. 934 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 吉田常孝: "アルツハイマー病の^<123>I-IMP ARG法を用いた脳血流SPECTと治療効果予測の可能性について"臨床放射線. 48・2. 306-310 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tunetaka Yoshida: "Recent Advances in Human Brain Mapping"Koichi Hirata, Yoshihiko Koga, Ken Nagata and Kaoru Yamazaki, Elsevier. 5 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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