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Mechanisms for the Progression of Renal Disease - Fatty Acids as an Aggravating Factor and Fatty Acid Binding Protein as an Ameliorating Factor

Research Project

Project/Area Number 13671099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

KIMURA Kenjiro  St. Marianna University School of Medicine, Internal Medicine, Professor, 医学部, 教授 (00161555)

Co-Investigator(Kenkyū-buntansha) HIRATA Yasunobu  University of Tokyo, Internal Medicine, Lecturer, 医学部付属病院, 講師 (70167609)
SUGAYA Takesi  Tanabe Seiyaku Co., Research Institute, Researcher, 創薬研究所, 主任研究員
SATO Takeo  St. Marianna University School of Medicine, Internal Medicine, Lecturer Chief, 医学部, 講師 (40215801)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsfatty acid binding protein / renal damage / proteinuria / proximal tubule / cultured tubular cells / transgenic mice / トランスジェニックスマウス
Research Abstract

In order to clarify the pathogenesis of the tubulointerstitial damage by proteinuria, we performed the following experiments.
Bovine serum albumin (BSA) was intraperitoneally injected for 2 weeks. Normal BSA induced remarkable tubulointerstitial damage, while defatted BSA did mild tubulointerstitial damage. The cultured proximal tubules similarly took normal BSA and defatted BSA into the cytoplasm. We established transgenic mice where human L-FABP was expressed in the proximal tubule. Intraperitoneal injection of normal BSA into the transgenic mice made severe tubulointerstitial damage and the expression of L-FABP was enhanced. Urinary excretion of L-FABP was increased. However, defatted BSA induced only mild tubulointerstitial damage. Neither the renal expression of L-FABP nor the urinary excretion of L-FABP was changed.
In conclusion, fatty acid bound to albumin play an important role in the pathogenesis of the tubulointerstitial damage induced by proteinuria. Fatty acid stress to the proximal tubule increased the renal expression and urinary excretion of L-FABP.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Kamijo A, Kimura K et al.: "Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage"Kidney International. 62. 1628-1637 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 上條敦子, 木村健二郎: "尿中肝臓型fatty acid binding Protein(L-FABP)の意義"Annual Review 腎臓 2001(編集:伊藤克己, 浅野泰, 遠藤仁,御手洗哲也, 東原英二). 53-57 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamijo A, Kimura K et al.: "Urinary Fatty Acids Bound to Albumin is an Aggravating Foctor For the Tubulointerstitial Damage in Chronic Renal Disease"Journal of American Society of Nephrology. 12:Abstract Issue. 680A (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamijo A, Kimura K et al: "Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage"Kidney International. 62. 1628-1637 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamijo A, Kimura K et al.: "Urinary fatty acids bound to albumin is an aggravating factor for the tubulointerstitial damage in chronic renal disease"Journal of American Society of Nephrology. 12 abstract issue, 680A. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kamijo A, Kimura K et al.: "Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage"Kidney International. 62. 1628-1637 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 上條敦子, 木村健二郎: "尿中肝臓型fatty acid binding protein (L-FABP)の意義"Annual Review腎臓2001(編集:伊藤克己、浅野泰、遠藤仁、御手洗哲也、東原英二). 53-57 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamijo A, Kimura K et al.: "Urinary Fatty Acids Bound to Albumin is an Aggravating Factor For the Tubulointerstitial Damage in Chronic Renal Disease"Journal of American Society of Nephrology. 12・(Abstract Issue). 680A (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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