| Project/Area Number |
13671125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Jichi Medical School |
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Principal Investigator |
KUSANO Eiji Jichi Medical School, Div Nephrol, Professor, 医学部, 教授 (50102249)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Yasuhiro Jichi Medical School, Div Nephrol, Associate professor, 医学部, 助教授 (50212676)
KOMATSU Norio Jichi Medical School, Div Hematol, Associate professor, 医学部, 助教授 (50186798)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | signal transuduction / erythropoietin / hypertension / vasular smooth muscle cell / MAPK system / cAMP / endothelial progenitor cells / 透析患者 / 心血管系合併症 / 血管新生 / VEGF / cAMP / 血管平滑筋細胞 / MAPK / protein kinase A / 細胞増殖 / 培養血管平滑筋細胞 |
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| Research Abstract |
We have examined mechanism of pathogenesis of the eythropoietin (EPO)-induced hypertension until now in cultured vascular smooth muscle cell and by dialysis patients. Since antiplatelet drug & induces inducible nitric oxide synthase (iNOS). this drug brings about direct decrease of blood pressure with the stimulation of the NO production, and the possibility of inducing decrease of blood pressure by the induction of the apoptosis of vasucular smooth muscle through the remodeling of blood vessel has been reported. In the present study, we would like to clarify the mechanism of pathogenesis of the EPO-induced hypertension by investigating the signal transduction system in vascular smooth muscle cell.
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