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Protection of hepatic microcirculatory disturbance due to the ischemia-reperfusion injury

Research Project

Project/Area Number 13671278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

TODOROKI Takeshi  University of Tsukuba, Institute of clinical medicine, assistant professor, 臨床医学系, 助教授 (70114105)

Co-Investigator(Kenkyū-buntansha) HIRANO Takashi  National Insitute of Advanced Industrial Science and Technology, Generalige Risearcher, 分子細胞工学研究部門, 副研究部門長・総括研究員
MIYAUCHI Takashi  University of Tsukuba, Institute of clinical medicine, assistant professor, 臨床医学系, 講師 (60222329)
KAWAMOTO Toru  University of Tsukuba, Institute of clinical medicine, assistant professor, 臨床医学系, 講師 (30282354)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsliver microcirculation / ischemia-reperfusion injury / endothelin receptor antagonist / central venous flow / sinusoid perfusion / leukocyte adhesion / liver dysfunction / SB209670 / 肝阻血再潅流障害 / エンドセリン拮抗薬 / 中心静脈血行 / 胆汁排泄 / 肝酵素
Research Abstract

Abstract
[Background/Aim] A synthesized non-peptide endothelin receptor; SB209670 (SB) reported to inhibit vasoconstriction; however its effects on the post-ischemic liver microcirculation (PILMC) is still unclear. To clarify the effects of SB on the PILMC was the aim of this study.
[Material and Methods] We analyses the effects of SB on not only PILMC, but also release of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) and the hepatocyte morphology after ischemia by intravital fluorescent microscopy. [Results] SB significantly inhibited the sinusoidal vasoconstriction, leukocyte sticking and restored the perfusion rate than NaCl administration in comparison with those of non-ischemic liver, 94.1%; vs. 83.8%, 1.54/acini vs. 5.12/acini and 93.3% vs. 70. 2%, respective, however, it did not the vasoconstriction and leukocyte sticking in the post-sinusoidal venule. SB also did not prevent release of liver enzyme and the increase of the vacuolated hepatocyte number. [Conclusion] SB protects the post-ischemic microcirculatory disturbance in the sinusoid, however it did not prevent ischemic reperfusion liver injury provably due to the conflictive effects in the post-sinusoidal venule.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (21 results)

All 2003 2002 Other

All Journal Article (13 results) Book (1 results) Publications (7 results)

  • [Journal Article] 血行再建を伴う胆のう癌切除術2003

    • Author(s)
      轟健
    • Journal Title

      手術 57・2

      Pages: 151-156

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] The blood circulation rebuilding and gallbladder cancer exsection to be accompanied with2003

    • Author(s)
      T.Todoroki
    • Journal Title

      Operation 57(2)

      Pages: 151-156

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expression of Cyclooxygenase-2 in the Subserosal Layer Correlates with Postsurgical Prognosis of Pathological Tumor Stay Carcinoma of the Gallbladder2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Int.J.Cancer 8・4

      Pages: 427-434

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Synthesis and Properties of Poly[N-(2-hydroxypropyl)methacrylamide] Conjugates of Superoxide Dismutase2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Journal of Bioactive and Compatible Polymers 196・13

      Pages: 105-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expression of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder : Crucial Role of Arachidonate Metabolism in Tumors with Progres2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Clinical Cancer Research 8

      Pages: 1157-1167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] E-cadherin Expression in the Primary Tamors and Metastatic Lymph Nodes of poorly Differentiated Types of Rectal cancer.2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Surgery Today 32・2

      Pages: 123-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Role of platelet-activating factor in hepatectomy with Pringle's maneuver2002

    • Author(s)
      轟健
    • Journal Title

      手術 56・9

      Pages: 1291-1296

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Synthesis and Properties of Poly [N-(2-hydroxyproprl)ethacrylaide] Conjugates of Superoxide Dismutase2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Journal of Bioactive and Compatible Polymers 196(13)

      Pages: 105-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expression of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder : Crucial Role of Arachidonate Metabolism in Tumors with Progress2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Clinical Cancer Research 8

      Pages: 1157-1167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] E-cadherin Expression in the Primary Tumors and Metastatic Lymph Nodes of poorly Differentiated Types of Rectal cancer2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Surgery Today 32(2)

      Pages: 123-128

    • NAID

      10017517562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Role of platelet-activating factor in hepatectomy with Pringle's maneuver2002

    • Author(s)
      T.Todoroki
    • Journal Title

      Operation 56(9)

      Pages: 1291-1296

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Expression of Cyclooxygenase-2 in the Subserosal Layer Correlates with Postsurgical Prognosis of Pathological Tumor Stage Carcinoma of the Gallbladder

    • Author(s)
      T.Todoroki
    • Journal Title

      Int.J.Canser 8(4)

      Pages: 427-434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Fire extinguisher surgery12 A topic around a fire extinguisher image

    • Author(s)
      T.Todoroki
    • Journal Title

      Heath Publication

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Book] 消化器外科12 消化器画像をめぐる話題2002

    • Author(s)
      轟健
    • Total Pages
      6
    • Publisher
      へるす出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Todoroki: "Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder"Int.J.Cancer. 98. 427-434 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Todoroki: "Synthesis and Properties Poly [N-(2-hydroxypropyl) methacrylamide] Conjugates of Superoxide Dismutase"Journal of Bioactive and Compatible Polymers. 17. 105-122 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Todoroki: "Expressions of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder : Crucial Role of Arachidonate Metabolism in Tumor Growth and Progression^1"Clinical Cancer Research. 8. 1157-1167 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Todoroki: "E-Cadherin Expression in the Primary Tumors and Metastatic Lymph Nodes of Poorly Differentiated Types of Rectal Cancer"Surgery Today. 32・2. 123-128 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 轟健: "上中部胆管癌に対する胆道切除・再建"手術. 56・9. 1291-1296 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 轟健: "血行再建を伴う胆のう癌切除術"手術. 57・2. 151-156 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 轟健: "消化器外科 12 消化器画像をめぐる話題"へるす出版. 6 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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