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Evaluation of risk factors for recurrence after potentially curative surgery for colorectal carcinoma using cDNA array

Research Project

Project/Area Number 13671333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionJichi Medical School

Principal Investigator

KAWAMURA Yutaka  Faculty of Medicine, Jichi Medical School. Assistant Professor, 医学部, 講師 (80301109)

Co-Investigator(Kenkyū-buntansha) OKADA Masaki  Faculty of Medicine, Jichi Medical School. Associate Professor, 医学部, 助教授 (40254924)
KONISHI Fumio  Faculty of Medicine, Jichi Medical School. Professor, 医学部, 教授 (20142242)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordscDNA array / colorectal cancer / chemotherapy / recurrence / 術後再発 / 肝転移 / 補助療法 / 血行性転移 / 再発
Research Abstract

Standard adjuvant therapy after potentially curative surgery for colorectal cancer is chemotherapy using 5-fluorouracil and leucovorine. The indication have been determined according to TNM stage ; Patients with stage III disease, or with lymph node metastasis, are candidates for adjuvant chemotherapy. Therefore, many patients without occult metastasis have been received unnecessary chemotherapy due to the lack of precise method for determine the risk factors for postoperative recurrence. On the other hand, patients with occult metastasis, but without lymph node metastasis, were not considered to be indicated for postoperative chemotherapy.
This study was conducted to develop precise method to determine patients with occult metastasis after apparently curative resection using cDNA array on which 550 cancer-related genes were blotted.
Patients with colorectal carcinoma who had undergone potentially curative resection and survived without recurrence for 5 years (Group A) and those with hepatic metastasis (Group B) were compared in terms of gene expression profile determined by cDNA array.
We found 9 genes with higher and 22 genes with lower expression in patients in Group B compared to those in Group A.
Using this gene expression profile, the risk of hepatic recurrence can be determined with the accuracy of 80%, which is much better than conventional TNM stage-related decision making.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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