| Project/Area Number |
13671350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon medical school |
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Principal Investigator |
TAJIRI Takashi Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20163462)
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| Co-Investigator(Kenkyū-buntansha) |
TANIAI Nobuhiko Nippon medical School, Assistant, 医学部, 助手 (20287725)
MAMADA Yasuhiro Nippon Medical School, Assistant, 医学部, 助手 (40312061)
YOSHIDA Hiroshi Nippon medical School, Assistant Professor, 医学部, 講師 (60246999)
恩田 昌彦 日本医科大学, 医学部, 教授 (70089697)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | liver cirrhosis / liver volume / portal hemodynamics / Scintiphotosplenoportography / Technetium-99m-diethylenetriaminepentaacetic acid-galactosylated human serum albumin / 代償性肥大 / 脾摘 / 肝再生 / 脾静脈血 |
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| Research Abstract |
We studied the distribution of splenic venous flow in the liver of patients with normal liver (NL group, n=15), chronic hepatitis (CH group, n=8), and liver cirrhosis (LC group, n=13) with the technique of scintiphotosplenoportography (SSP) after percutaneous intrasplenic injection of Technetium-99m-diethylenetriaminepentaacetic asid-galactosyl-human serum albumin (99mTc-GSA). The index of splenic venous flow volume per unit hepatocytes (V_<unit>) was calculated in each hepatic lobe. To compare V value of the left lobe (VL_<unit>) with that of the right lobe (VR_<unit>), predominant index of the left lobe (L/R index) was defined as L/R index=VL_<unit>/VR_<unit>. The median (interquartile range) of L/R index of LC group; 1.22 (1.06-1.70) was significantly higher than that of NL group; 0.83 (0.66-0.92), p<0.001 and CH group; 0.79 (0.69-0.92), p<0.001. L/R index reflects the change of portal hemodynamics in cirrhotic liver and is useful for discrimination between noncirrhosis and cirrhosis. These results suggest that in the liver exposed to continuous damages, splenic venous blood promotes liver fibrosis in the right lobe and eventually flows more into the left lobe with milder fibrosis.
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