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Basic and clinical studies for development of peptide vaccine for colorectal cancer

Research Project

Project/Area Number 13671362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKurume University

Principal Investigator

SASATOMI Teruo md  KURUME UNIVERSITY, School of Medicine, Assistant, 医学部, 助手 (20196190)

Co-Investigator(Kenkyū-buntansha) UTOH Kyogo md  KURUME UNIVERSITY, School of Medicine, Professor, 医学部, 教授 (50125499)
SHIROUZU Kazuo md  KURUME UNIVERSITY, School of Medicine, Professor, 医学部, 教授 (20216203)
山名 秀明  久留米大学, 医学部, 教授 (30140669)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordscolorectal cancer / peptide vaccine / immunotherapy / 再発進行大腸癌 / 特異的CTL / 癌免疫療法 / ペプチド / 臨床第1相臨床試験 / 特異的免疫療法
Research Abstract

HLA-A24 or HLA-A2 positive 17 patients with recurrent colorectal cancers were accepted cancer vaccine therapy. All the patients was ineffective at chemotherapy. First, we had checked skin test and CTL precursor frequency of patient for our cancer peptide vaccines. Then, each patient had been tried 3mg of three or four most frequent cancer vaccines intradermaly three times bi-weekly, and at the fourth trial, cancer peptide vaccines and intravenous 5FU(750mg) and Leucovorin(250mg) combined therapy had been star every other weeks. We have been investigated CTL precursor frequency all the period. CTL precursor frequencies were increased in all the patients. At seven of 14 patients, Ig G antibodies for cancer peptide vaccines were increased. And there were no severe adverse effects. Tumor markers (CEA) and tumor sizes were decreased and alive more than ten months. Two ware survived more than 1 year and two ware survived more than 2 years. We think our combined cancer vaccine and chemotherapy, intravenous 5FU(750mg) and Leucovorin(250mg), may be effective for patients with recurrent colorectal cancers after sugery.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Sato Y, Satomi T. et al.: "A phase I trial of cytotoxic T-lymphocyte precursor-oriented peptide vaccines for colorectal carcinoma patients."Br J Cancer. 90. 1334-1342 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mine T, Sasatomi T. et al.: "Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides based on pre-existing, peptide-specific cellular responses"Clin Cancer Res.. 10. 929-937 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasatomi T, Itoh K, Shirouzu K. et al.: "Expression of tumor rejection antigens in colorectal carcinomas."Cancer. 94. 1636-1641 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyagi Y, Sasatomi T, Itoh K, Shirouzu K. et al.: "Induction of Cellular Immune Responses to Tumor Cells and Peptides in Colorectal Cancer Patients by Vaccination with SART3 Peptides"Clin Cancer Res.. 7. 3950-3962 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasatomi T, Yamana H, Shirouzu K. et al.: "Cellular immunotherapy for local recurrence of rectal cancer after surgery by activated lymphocyte administration--a case report"Gan To Kagaku Ryoho.. 28. 1692-1695 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Harashima N, Yamana H, Itoh K. et al.: "Recognition of the Lck tyrosine linase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases"Eur.J.Immunol.. 31. 323-332 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 笹富輝男, 白水和雄: "消化器癌のサーベイランス IV.トピックス 4.消化器癌に対する癌ワクチン療法"新興医学出版社 東京. 4 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato Y, Sasatomi T, Itoh K, et al.: "A phase I trial of cytotoxic T-lymphocyte precursor-oriented peptide vaccines for colorectal carcinoma patients."Br J Cancer.. 90. 1334-1342 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mine T, Sasatomi T, Shirouzu K, Itoh K, Yamana H.et al.: "Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides based on pre-existing, peptide-specific cellular responses."Clin Cancer Res.. 10. 929-937 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toh U, Yamana Sasatomi T, Shirouzu K. et al.: "Autologous tumor specific immunotherapy of refractory cancers with ex vivo-generated T cells stimulated by autologous tumor cell [Article in Japanese]"Gan To Kagaku Ryoho.. 30(11). 1566-1570 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K.: "Expression of tumor rejection antigens in colorectal carcinomas."Cancer.. 94. 1636-1641 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Miyagi Y, Imai N, Sasatomi T, Yamada A, Mine T, Katagiri K, Nakagawa M, Muto A, Okouchi S, Isomoto H, Shirouzu K, Yamana H, Itoh K.: "Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides."Clin Cancer Res.. 7. 3950-3962 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sasatomi T, Toh U, Miyagi Y, Ishibashi N, Araki Y, Ogata Y, Yamana H, Shirouzu K.: "Cellular immunotherapy for local recurrence of rectal cancer after surgery by activated lymphocyte administration--a case report [Article in Japanese]"Gan To Kagaku Ryoho.. 28. 1692-1695 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suefuji Y, Sasatomi T, Shichijo S, Nakagawa S, Deguchi H, Koga T, Kameyama T, Itoh K.: "Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients."Br J Cancer.. 84. 915-919 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Harashima N, Tanaka K, Sasatomi T, Shimizu K, Miyagi Y, Yamada A, Tamura M, Yam ana H, Itoh K, Shichijo S.: "Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases."Eur J Immunol.. 31. 323-332 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mine T, Sasatomi T, Itoh K et al.: "Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides based on pre-existing, peptide-specific cellular responses"Clinical Cancer Research. 10(1). 929-937 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toh U, Sasatomi T, Yamana H et al.: "Autologous tumor specific immunotherapy of refractory cancers with ex vivo-generated T cells stimulated by autologous tumor cell"Gan To Kagaku Ryoho. 30(11). 1566-1570 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sasatomi T, Itoh K, Shirouzu K et al.: "Expression of tumor rejection antigens in colorectal carcinomas."Cancer. 94(6). 1636-1641 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nozoe Y, Ogata Y, Sasatomi T, Shirouzu K et al.: "Up-regulation in dihydropyrimidine dehydrogenase activity by raltitrexed causes antagonism in combination with 5-fluorouracil"Anticancer Research. 23(6). 4663-4669 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Miyagi Y, Sasatomi T, Shirouzu K, Yamana H, Itoh K et al.: "Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides"Clinical Cancer Research. 7(12). 3950-3962 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shirouzu K, Ogata Y, Araki Y, Sasatomi T et al.: "Total mesorectal excision, lateral lymphadenectomy and autonomic nerve preservation for lower rectal cancer : significance in the long-term follow-up study"Kurume Medical Journal. 48(4). 307-319 (2001)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Sasatomi, K Ito, K Shirouzu et al.: "Expression of the tumor-rejection antigens in colorectal cancers"Cancer. (in press). (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshiaki Miyagi, Teruo Sasatomi, Kyogo Ito, Kazuo Shirouzu et al.: "Induction of Cellular Immune Responses to Tumor Cellsand Peptides in Colorectal Cancer Patients by Vaccination with SART3 Peptides"Clinical Cancer Reseach. 7. 3950-3962 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Teruo Sasatomi, Kazuo Shirouzu et al.: "Total mesorectal excision, lateral lymphadectomy and automatic nerve preservation for lower rectal cancer : significance in the long-term follow-up study"Kurume Medical Journal. 48. 307-319 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Sasatomi, K Ito, K Shirouzu et al.: "Expression of the tumor-rejection antigens in colorectal cancers"Cancer. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshiaki Miyagi, Teruo.Sasatomi, Kyogo Ito, Kazuo Shirouzu et al.: "Induction of Cellular Immune Responses to Tumor Cellsand Peptides in Colorectal Cancer Patients by Vaccination with SART3 Peptides"Clinical Cancer Reseach. 7. 3950-3962 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Sasatomi, K Ito, K Shirouzu et al.: "Expression of the SART1 tumor-rejection antigens in colorectal cancers"Dis Colon Rectum. 43. 1754-1758 (1999)

    • Related Report
      2001 Annual Research Report
  • [Publications] Teruo.Sasatomi, Kazuo Shirouzu et al.: "Total mesorectal excision, lateral lymphadectomy and automatic nerve preservation for lower rectal cancer : significance in the long-term follow-up study"Kurume Medical Journal. 48. 307-319 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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