| Project/Area Number |
13671377
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyorin University (2002-2003)
The University of Tokyo (2001) |
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Principal Investigator |
KUBOTA Hiroshi Kyorin University, Department of Cardiovascular Surgery, Associate Professor, 医学部, 助教授 (00262006)
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| Co-Investigator(Kenkyū-buntansha) |
KOTSUKA Yutaka Tokyo University, Cardiac Surgery, Associate Professor, 医学部, 助教授 (10126055)
TAKAMOTO Shinichi Tokyo University, Cardiac Surgery, Professor, 医学部, 教授 (60137833)
FUJIKI Tatsuo Kyorin University, Cardiovascular Surgery, Assistant Professor, 医学部, 助手
SUDO Kenichi Kyorin University, Cardiovascular Surgery, Professor, 医学部, 教授 (10111527)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | atrial fibrillation / maze procedure / ablation / surgical treatment / infrared ablation / cryoablation / arrhythmia / thoracoscope / 心房凝固 / 低侵襲外科治療 / 手術 / 心拍動下手術 / 心房アブレーション / MAZE手術 |
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| Research Abstract |
Recently, surgical treatment of arrhythmia has been widespread. Especially, the surgical treatment of the atrial fibrillation : MAZE procedure has been noticed and has been done by many cardiac surgeon. This procedure can cure the atrial fibrillation by means of cutting and sewing both atrium to recover sinoatrial conduction. However, there are several drawbacks e.g. complicated cutting line, prolongation of the aortic crosclamp time, bleeding. Instead of cut and sew technique, other ablation devices have been developed to solve these problems, there is no device which solve all of these problems. We focused on cryoablation and infrared coagulation systems.
Epicardial cryoablation technique (LAVIE) was applied to seven patients. All patient except one has recovered sinus rhythm several weeks after the procedure spontaneously. These are the first cases in the world and presented in The Annals of Thoracic Surgery in 2004. The efficacy of the infrared coagulator also demonstrated in the animal experience using canine and the results will be published in The Annals of Thoracic Surgery this year.
The first clinical application of infrared coagulator has been done in 2005, however it failed because of the carbonization of the atrial tissue. We noticed that not only the ablation duration but also energy output is important to control the depth of coagulation, and modified the coagulator to be an energy output controllable one.
These results were presented at the 20^<th> Meeting of Japanese pacing and electrophysiological Society in May 2005.
The latest model of infrared coagulator is ready to use clinically.
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