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Thoracoscopic treatment of atrial fibrillation on the beating heart

Research Project

Project/Area Number 13671377
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKyorin University (2002-2003)
The University of Tokyo (2001)

Principal Investigator

KUBOTA Hiroshi  Kyorin University, Department of Cardiovascular Surgery, Associate Professor, 医学部, 助教授 (00262006)

Co-Investigator(Kenkyū-buntansha) KOTSUKA Yutaka  Tokyo University, Cardiac Surgery, Associate Professor, 医学部, 助教授 (10126055)
TAKAMOTO Shinichi  Tokyo University, Cardiac Surgery, Professor, 医学部, 教授 (60137833)
FUJIKI Tatsuo  Kyorin University, Cardiovascular Surgery, Assistant Professor, 医学部, 助手
SUDO Kenichi  Kyorin University, Cardiovascular Surgery, Professor, 医学部, 教授 (10111527)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsatrial fibrillation / maze procedure / ablation / surgical treatment / infrared ablation / cryoablation / arrhythmia / thoracoscope / 心房凝固 / 低侵襲外科治療 / 手術 / 心拍動下手術 / 心房アブレーション / MAZE手術
Research Abstract

Recently, surgical treatment of arrhythmia has been widespread. Especially, the surgical treatment of the atrial fibrillation : MAZE procedure has been noticed and has been done by many cardiac surgeon. This procedure can cure the atrial fibrillation by means of cutting and sewing both atrium to recover sinoatrial conduction. However, there are several drawbacks e.g. complicated cutting line, prolongation of the aortic crosclamp time, bleeding. Instead of cut and sew technique, other ablation devices have been developed to solve these problems, there is no device which solve all of these problems. We focused on cryoablation and infrared coagulation systems.
Epicardial cryoablation technique (LAVIE) was applied to seven patients. All patient except one has recovered sinus rhythm several weeks after the procedure spontaneously. These are the first cases in the world and presented in The Annals of Thoracic Surgery in 2004. The efficacy of the infrared coagulator also demonstrated in the animal experience using canine and the results will be published in The Annals of Thoracic Surgery this year.
The first clinical application of infrared coagulator has been done in 2005, however it failed because of the carbonization of the atrial tissue. We noticed that not only the ablation duration but also energy output is important to control the depth of coagulation, and modified the coagulator to be an energy output controllable one.
These results were presented at the 20^<th> Meeting of Japanese pacing and electrophysiological Society in May 2005.
The latest model of infrared coagulator is ready to use clinically.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All 2005 2004 2003 Other

All Journal Article (6 results) Book (1 results) Publications (7 results)

  • [Journal Article] Epicardial Maze Procedure on the Beating Heart With an Infrared Coagulator2005

    • Author(s)
      Kubota H, Takamoto S, Furuse A, Sato M, Endo H, Fujiki T, Sudo K
    • Journal Title

      Annals of Thoracic Surgery (In Press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Epicardial Maze Procedure on the Beating Heart With an Infrared Coagulator2005

    • Author(s)
      Kubota H, Takamoto S, Furuse A, Sato M, Endo H, Fujiki T, Sudo K
    • Journal Title

      Annals of thoracic surgery (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Epicardial pulmonary vein isolation with a hook-shaped cryoprobe to treat atrial fibrillation2004

    • Author(s)
      Kubota H, Takamoto S, Ohtsuka T, Endo H, Sato M, Fujiki T, Sudo K.
    • Journal Title

      Annals of Thoracic Surgery 78

      Pages: 1056-1059

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Epicardial pulmonary vein isolation with a hook-shaped cryoprobe to treat atrial fibrillation2004

    • Author(s)
      Kubota H, Takamoto S, Ohtsuka T, Endo H, Sato M, Fujiki T, Sudo K.
    • Journal Title

      Annals of thoracic surgery 78

      Pages: 1056-1059

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Epicardial Pulmonary Vein Isolation to Treat Non-Valvular Atrial Fibrillation. Using Cryoablation as Concomitant Cardiac Surgery2003

    • Author(s)
      Kubota H, Takamoto S, Morota T, Ohtsuka T, Motomura N, Kotsuka Y, Sudo K.
    • Journal Title

      Annals of Thoracic Surgery 75

      Pages: 590-593

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Journal Article] Epicardial Pulmonary Vein Isolation to Treat Non-Valvular Atrial Fibrillation Using Cryoablation as Concomitant Cardiac Surgery2003

    • Author(s)
      Kubota H, Takamoto S, Morota T, Ohtsuka T, Motomura N, Kotsuka Y, Sudo K.
    • Journal Title

      Annals of thoracic surgery 75

      Pages: 590-593

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Book] Annual Review 循環器 V.心臓血管外科と遠隔成績 3.心房細動に対する低侵襲手術2003

    • Author(s)
      窪田博
    • Total Pages
      276
    • Publisher
      中外医薬社、東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 窪田 博: "心臓外科と遠隔成績:心房細動に対する低侵襲手術"Annual Review循環器、東京、中外医薬社. 225-230 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroshi Kubota et al.: "Cryoablation as Concomitant Cardiac Surgery to Treat Non-Valvular Atria 1 Fibrillation "LAVIE Technique""ICPES proceedings MONDUZZI EDITORE. D219C0274. 129-132 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroshi KUBOTA: "Epicardial Pulmcnary Vein Isolation to Treat Non-Valvular Atrial Fibrillation Using Cryoablation as Concomitant Cardiac Surgery"Annals of Thoracic Surgery. 75(2). 590-593 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroshi KUBOTA: "Epicardial Pulmonary Vein Isolation by Cryoablation as Concomitant Cardiac Surgery to Treat Non-Valvular Atrial Fibrillation "Lavie Technque""ICPES proceedings, MONDUZZI EDITORE. D219CO274. 129-132 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 窪田 博(分担): "Annual Review 循環器V.心臓血管外科と遠隔成績(3.心房細動に対する低侵襲手術)"中外医薬社. 6(225-230) (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroshi Kubota, et al.: "Thoracoscopic epicardial pulmonary vein isolation"Circulation. 104・17. II-48 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiroshi Kubota, et al.: "Beating MAZE procedure using an infrared coagulator"Journal of the American College of Cardiology. 37・2. 109-A (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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