Molecular biological study on pathogenesis of thymic epithelial tumors by microarray method

• Project/Area Number: 13671384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: OKUMURA Meinoshin Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (40252647)
• Co-Investigator(Kenkyū-buntansha): OHTA Mitsunori Osaka University, School of Medicine, Assistant Professor, 医学系研究科, 助手 (30203805) ; MINAMI Masato Osaka University, School of Medicine, Assistant Professor, 医学系研究科, 助手 (10240847)
• Project Period (FY): 2001 – 2002
• Project Status: Completed (Fiscal Year 2002)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000); Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: Thymoma / WHO histological classification / DNA chip

Research Abstract

WHO histological classification of thymic epithelial tumors has been shown to reflect their biological behavior. This study was designed to determine whether WHO histological classification reflects difference of expression of the specific genes
RNAs were obtained from the primary culture of thymomas, and were subjected to the microarray study. RNAs derived from type AB tumor and type B2 tumor were compared. Assay was done twice in 2 independent sets of tumors
There were 333 genes whose expression was more than two times in type B2 tumor than in type AB tumor,,and 395 genes whose expression was more than 2 times in type AB tumor than in type B2 tumor, reproducibly

Research Products

• [Publications] Meinoshin Okumura, et al.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms A study of 146 consecutive tumors"The American J.Surgical Pathology. 25・1. 103-110 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Meinoshin Okumura, et al.: "Three-color flow cytometric study on lymphocytes derived from thymic diseases"J.Surgical Research. 101. 130-137 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Meinoshin Okumura, et al.: "The World Health Organization histologic classification system reflects the oncologic behavior of thymoma A clinical study of 273 patients"Cancer. 94・3. 624-632 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Okumura M, Miyoshi S, Fujii Y, Takeuchi Y, Shiono H, Inoue M, Fukuhara K, Kadota Y, Tateyama H, Eimoto T, Matsuda H.: "Clinical and functional significance of WHO classification on human thymic epithelial neoplasms A study of 146 consecutive tumors"The American J.Surgical Pathology. 25(1). 103-110 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Okumura M, Fujii Y, Miyoshi S, Shiono H, Inoue M, Kadota Y, Fukuhara K, Matsuda H.: "Three-color flow cytometric study on lymphocytes derived from thymic diseases"J.Surgical Research. 101. 130-137 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Okumura M, Ohta M, Tateyama H, Nakagawa K, Matsumura A., Maeda H, Tada H, Eimoto T, Matsuda H, Masaoka A.: "The World Health Organization histologic classification system reflects the oncologic behavior of thymoma : a clinical study of 273 patients"Cancer. 94(3). 624-632 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Meinoshin Okumura, et al.: "Clinical and functional significance of WHO classification on human thymic epitelial neoplasms A study of 146 consecutive tumors"The American J. Surgical Pathology. 25・1. 103-110 (2001)
• [Publications] Meinoshin Okumura, et al.: "Three-color flow cytometric study on lymphocytes derived from thymic diseases"J. Surgical Research. 101. 130-137 (2001)
• [Publications] Meinoshin Okumura, et al.: "The World Health Organization histologic classification system reflects the oncologic behavior of thymoma A clinical study of 273 patients"Cancer. 94・3. 624-632 (2002)