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Regulation of Reactive Amyloidosis via Activation of Peroxisome Proliferator Activated Receptor α

Research Project

Project/Area Number 13671496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

OGOSE Akira (2002)  NIIGATA UNIVERSITY University Medical Hospital. Lecturer, 医学部附属病院, 講師 (80323963)

羽生 忠正 (2001)  新潟大学, 大学院・医歯学総合研究科, 助教授 (20189591)

Co-Investigator(Kenkyū-buntansha) YAMADA Toshiyuki  Jyuntendo University, Faculty of Medicine, Associate professor, 医学部, 助教授 (50211636)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsReactive Amyloidsis / SAA / PPAR α / Fibrate / PPARα
Research Abstract

This study demonstrated that
1) Fenofibrate inhibited reactive AA-amyloidosis by reducing SAA in an inflammatory murine model.
2) Fenofibric acid inhibited the SAA production from hepatocyte (HepG2 cell) stimulated by pro-inflammatory cytokines such as IL-1β and IL-6.
3) Fenofibric acid inhibited the production of IL-1β and IL-6 from monocyte (RAW264 cell) stimulated by lipopolysaccharide.
4) The PPARα expression was not found in monocyte (macrophage) by RT-PCR. Peroxisome proliferator response element (PPRE), to which the PPARα-RXR heterodimer directly bind, was not found on the gene arrangement of IL-1, IL-6 and SAA.
5) The activation of nuclear factor κB (NF-κB), which regulates transcription of genes encoding inflammatory cytokines and SAA, was down regulated in the inflammatory condition in vitro.
6) Fenofibrate did not inhibit adjuvant arthritis in rat model. The expression of PPARα is not observed in the human synovium of rheumatoid arthritis.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] T.Yamada: "Relative serum amyloid A (SAA) values : the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis"Annals of the Rheumatic Diseases. 60(2). 124-127 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yamada: "Further characterization of serum amyloid A4 as a minor acute phase reactant and a possible nutritional marker"Clinical Chemistry and Laboratory Medicine. 39(1). 7-10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Murai: "Fenofibrate Inhibits Reactive Amyloidosis in Mice"Arthritis & Rheumatism. 46(6). 1683-1688 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Yamada: "Relative serum amyloid A (SAA) values: the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis"Annals of the Rheumatic Diseases. 60(2). 124-127 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Yamada: "Further characterization of serum amyloid A4 as a minor acute phase reactant and a possible nutritional marker"Clinical Chemistry and Laboratory Medicine. 39(1). 7-10 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Murai T: "Fenofibrate Inhibits Reactive Amyloidosis in Mice"Arthritis & Rheumatism. 46(6). 1683-1688 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Murai: "Fenofibrate inhibits reactive amyloidosis in mice"Arthritis & Rheumatism. 46(6). 1683-1688 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Murai: "Fenofibrate inhibits reactive amyloidosis in mice"Arthritis & Rheumatism. (in press). (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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