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Free muscle transplantation: analysis of growth factor and its therapeutic effect

Research Project

Project/Area Number 13671513
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionYamaguchi University

Principal Investigator

IHARA Koichiro  Yamaguchi University Hospital, Associate Professor, 医学部附属病院, 助教授 (90184788)

Co-Investigator(Kenkyū-buntansha) 大藤 晃  山口大学, 医学部・附属病院, 医員(臨床)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsmuscle transplantation / growth factor / satellite cell / regeneration / gene analysis / reinnervation / 筋間細胞
Research Abstract

In 2001, free muscle transplantation model using Wister rat was created for the detection of growth factor, particularly b-FGF. Observation periods ranged from one day to 8 weeks, and the models were divided into 8 groups. In addition to histological examination, electromyogram was obtained for 2, 4 and 6 week model. M wave indicating reinnervation was detected in 4 week model, which was consistent with intraoperative findings of the muscle.
In 2002, PCNA stain and RT-PCR for b-FGF were performed. PCNA positive cell appeared the day after transplantation. It was also present 5 week postoperatively, although gradually decreased. Gene expression of b-FGF was also detected from one day to 5 week after transplantation, which suggested that b-FGF might be one of regulators for recovery of the transferred muscle

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Merida L, Shigetomi M, Ihara K, et al.: "Effects of vitamin D analog, 22-oxa-1,25-dihydroxyvitamin D(3), on bone reconstruction by vascularized bone allograft"Bone. 30・2. 422-427 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohno T, Shigetomi M, Ihara K, et al.: "Effects of cerivastatin on vascularized allogenic bone transplantation in rats treated with cyclosporine a"Calcif Tissue Int. 72・1. 50-56 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K, Shigetomi M, Muramatsu K, et al.: "Pedicle or free musculocutaneous flaps for shoulder defects after oncological resection"Ann Plast Surg. 50・4. 361-366 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 伊原公一郎, 重冨充則, 村松慶一, 他: "患肢温存手術における機能的筋肉移植の意義"別冊整形外科. 43. 198-203 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 伊原公一郎, 重冨充則, 村松慶一, 他: "骨軟部腫瘍治療における血管柄付き組織移植の有用性"骨・関節・靱帯. 16・4. 379-384 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K, Sakamoto S, Kawai S: "Computed tomography to evaluate postoperative changes in free functioning muscle"Eur J Plast Surg. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Merida L., Shigetomi M., Ihara K., et al.: "Effects of vitamin D analog, 22-oxa-l, 25-dihydroxyvitamin D (3), on bone reconstruction by vascularized bone allograft"Bone. 30. 422-427 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohno T., Shigetomi M., Ihara K., et al.: "Effects of cerivastatin on vascularized allogenic bone transplantation in rats treated with cyclosporine a"Calcif Tissue Int.. 72. 50-56 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K., Shigetomi M., Muramatsu K., et al.: "Pedicle or free musclocutaneous flaps for shoulder defects after oncological resection"Ann Plast Surg. 50. 361-366 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K., Shigetomi M., Muramatsu K., et al.: "Usefulness of functioning muscle transplantation in limb salvage surgery"Bessatsu Seikeigeka. 43. 198-203 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K., Shigetomi M., Muramatsu K., et al.: "The value of vascularized tissue transfer in musculoskeletal oncology"Kotsu・Kansetsu・Jintai. 16. 379-384 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ihara K., Sakamoto S., Kawai S.: "Computed tomography to evaluate postoperative changes in free functioning muscle"Eur. J. Plast. Surg.. In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Merida L, Shigetomi M, Ihara K, et al.: "Effects of vitamin D analog, 22-oxa-1,25-dihydroxyvitamin D(3), on bone reconstruction by vascularized bone allograft"Bone. 30.2. 422-427 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ohno T, Shigetomi M, Ihara K, et al.: "Effects of cerivastatin on vascularized allogemc bone transplantation in rats treated with cvclosuorine a"Calcif Tissue Int. 72.1. 50-56 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ihara K, Shigetomi M, Muramatsu K, et al.: "Pedicle or free musculocutaneous flaps for shoulder defects after oncological resection"Ann Plast Surg. 50(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Keiichi Muramatsu: "Vascular complication in free tissue transfer to the leg"Microsurgery. 21. 362-365 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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