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A study on the mechanism of General Anesthesia-inuduced sleep-relation to endogenous sleep related substances

Research Project

Project/Area Number 13671560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHirosaki University

Principal Investigator

MATSUKI Akitomo  Hirosaki University School of Medicine Professor, 医学部, 教授 (20003543)

Co-Investigator(Kenkyū-buntansha) KUBOTA Takeshi  Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員
KUSHIKATA Tetsuya  Hirosaki University, University Hospital Instructor, 医学部附属病院, 医員 (80250603)
HIROTA Kazuyoshi  Hirosaki University, University Hospital Lecturer, 医学部附属病院, 講師 (20238413)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsGeneral anesthetic agents / Sleep / Noradrenaline / Sleep Related Substance
Research Abstract

We studied an interaction among general anesthetics and endogenous sleep-related substance. It is suggested that post anesthesia sleep was affected by ketamine, a general anesthetics. We found that non-rapid eye movement sleep (NREMS) was reduced but REMS was increased after a few days later of ketamine anesthesia On the other hand, orexin, a wake-promote substance thus sleep-related substance, decreased anesthesia-induced loss of consciousness duration by several intravenous general anesthetics ; pentobarbital, thiopental and phenobarbital. Our results suggest that there would be some interaction among general anesthetics and endogenous sleep-related substance.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] Tetsuya Kushikata, Kazuyoshi Hirota, Hitoshi Yishida, Naoki Kotani, Akitomo Matsuki: "Orexin Decreases Barbiturates-Induced Sleeping Time"Anesthesiology. 95. A1371 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, Tsuyoshi Kudo, David G.Lambrt, Akitomo Matsuki: "Orexin A and b evoke noradrenaline release from rat cerebrocortical slices"British Journal of Pharmacology. 134. 1461-1466 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tetsuya Kushikata, Kazuyoshi Hirota, Hitoshi Yishida, et al.: "Orexin Decreases Barbiturates-Induced Sleeping Time"Anesthesiology. 95. A1371 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, et al.: "Orexin A and b evoke noradrenaline release from rat cerebrocortical slices"British Journal of Pharmacology. 134. 1461-1466 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tetsuya Kushikata, Kazuyoshi Hirota, Hitoshi Yishida, Naoki Kotani, Akitomo Matsuki: "Orexin Decreases Barbiturates-Induced Sleeping Time"Anesthesiology. 95. A1371 (2001)

    • Related Report
      2002 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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