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Direct action of general anesthetics on vascular smooth muscle and endothelium of systemic resistance arteries in various pathological conditions with impaired endothelial function.

Research Project

Project/Area Number13671590
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AKATA Takashi  Kyushu University Hospital, Anesthesiology, Assistant Professor, 講師 (10260382)

Project Period (FY) 2001 – 2004
Project Status Completed(Fiscal Year 2004)
Budget Amount *help
¥4,000,000 (Direct Cost : ¥4,000,000)
Fiscal Year 2004 : ¥600,000 (Direct Cost : ¥600,000)
Fiscal Year 2003 : ¥700,000 (Direct Cost : ¥700,000)
Fiscal Year 2002 : ¥1,000,000 (Direct Cost : ¥1,000,000)
Fiscal Year 2001 : ¥1,700,000 (Direct Cost : ¥1,700,000)
KeywordsVascular smooth muscle / Vascular endothelium / Halogenated volatile anesthetic / Isoflurane / Sevoflurane / Halothane / Enflurane / Mesenteric resistance vessels / エトミデート / 静脈麻酔薬 / ケタミン
Research Abstract

Geriatric, hypertensive, and diabetic patients are at increased risk for cardiovascular instability during general anesthesia with volatile anesthetics. We have recently shown that in systemic resistance arteries, volatile anesthetic actions on vascular reactivity are greatly influenced by the presence of endothelium (Anesthesiology 2000;92:1426-40,2001;95:990-8). Since aging, hypertension, and diabetes mellitus are all associated with alterations in endothelial function, volatile anesthetics may influence vascular reactivity differently in those populations. This study was designed to investigate possible changes in vascular responsiveness to volatile anesthetics in the presence of aging, hypertension, and diabetes mellitus.
Isometric force was recorded in small mesenteric arteries from young (7-8 weeks), middle-aged (24-27 weeks), geriatric (81-84 weeks), streptozotocin-induced diabetic (24-27 weeks), and spontaneously hypertensive (24-27 weeks) rats. The experiments were performed in … More either presence of endothelium or in its absence.
The concentration-response curve to norepinephrine, the sympathetic neurotransmitter, in the presence of endothelium was shifted to the left in the hypertensive, diabetic, and geriatric rats compared with healthy young or middle-aged rats. The concentration-response (i.e.endothelium-dependent vasorelaxation) curve to acethylcholine was shifted to the right in the hypertensive, diabetic, and geriatric rats compared with healthy young rats. Isoflurane and sevoflurane, in clinical concentrations, enhanced both submaximal and maximal responses to norepinephrine in an endothelium-dependent manner in healthy young and middle-aged rats, but not in the hypertensive, diabetic, and geriatric rats. No significant differences were observed in the concentration-response curve to norepinephrine or the anesthetic action on norepinephrine response in the absence of endothelium.
In mesenteric resistance arteries from the hypertensive, diabetic, and geriatric rats, endothelial function appears to be impaired, leading to enhanced contractile response to norepinephrine, attenuated vasodilator response to acethylcholine, and altered vascular response to volatile anesthetics. The enhancing action of isoflurane or sevoflurane on contractile response to norepinephrine, which has been shown to be mediated by endothelium in small mesenteric arteries, is inhibited in the presence of hypertension, diabetics, and aging, possibly contributing to the cardiovascular instability often observed in the hypertensive, diabetic, and aged subjects during anesthesia with isoflurane or sevoflurane. Less

Report

(5results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report

Research Products

(80results)

All 2005 2004 2003 2002 2001 Other

All Journal Article Book Publications

  • [Journal Article] ノルエピネフリン収縮反応に及ぼす揮発性吸入麻酔薬の効果-糖尿病ラット摘出腸間膜小動脈における検討-2005

    • Author(s)
      吉野 淳, 赤田 隆, 高橋成輔
    • Journal Title

      Journal of Anesthesia 19(Suppl)(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 揮発性吸入麻酔薬の抵抗血管平滑筋薬理学-加齢、高血圧、糖尿病に伴う血管応答の変化に注目して-2005

    • Author(s)
      赤田 隆
    • Journal Title

      日本臨床麻酔学会誌 25(8)(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of the direct action of sevoflurane on contractile response to norepinephrine in mesenteric resistance arteries between hypertensive and normotensive rats.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Anesthesia and Analgesia 100(2S):S-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Alterations in vascular responsiveness to volatile anesthetics in mesenteric resistance arteries from the streptozotocin-induced diabetic rats.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Anesthesia and Analgesia 100(2S):S-40

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct action of etomidate on contractile response to norepinephrine in rat small mesenteric arteries.2005

    • Author(s)
      Nakagawa A, Yoshino J, Akata T, Takahashi S
    • Journal Title

      Anesthesia and Analgesia 100(2S):S-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Age-related changes in volatile anesthetic actions on contractile response to norepinephrine in rat mesenteric resistance arteries.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Anesthesia and Analgesia 100(2S):S-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of the direct action of sevoflurane on contractile response to norepinephrine in mesenteric resistance arteries between hypertensive and normotensive rats.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Anesthesia and Analgesia 100(2S)

      Pages : S-39

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Alterations in vascular responsiveness to volatile anesthetics in mesenteric resistance arteries from the streptozotocin-induced diabetic rats.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Anesthesia and Analgesia 100(2S)

      Pages : S-40

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct action of etomidate on contractile response to norepinephrine in rat small mesenteric arteries.2005

    • Author(s)
      Nakagawa A, Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Anesthesia and Analgesia 100(2S)

      Pages : S-45

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Age-related changes in volatile anesthetic actions on contractile response to norepinephrine in rat mesenteric resistance arteries.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Anesthesia and Analgesia 100(2S)

      Pages : S-44

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of enflurane on vascular reactivity in isolated systemic resistance arteries. -Endothelium significantly influences vascular reactivity during exposure to enflurane-2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      8th America-Japan Anesthesia Congress Program Syllabus

      Pages : 12/S-8100

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Halothane influences vascular reactivity through multiple actions in isolated mesenteric resistance arteries.2005

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      8th America-Japan Anesthesia Congress Program Syllabus

      Pages : 12/S-8099

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Reliability of fingertip skin-surface temperature and its related thermal measures as indices of peripheral perfusion in the clinical setting....2004

    • Author(s)
      Akata T, Kanna T, et al.
    • Journal Title

      Anaesthesia and Intensive Care 32(4)

      Pages : 519-529

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of sevoflurane on contractile response to norepinephrine in systemic resistance arteries isolated from hypertensive rats.2004

    • Author(s)
      Yoshino J, Akata T, et al.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.)

      Pages : 289-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of etomidate on contractile response to norepinephrine in isolated systemic resistance arteries2004

    • Author(s)
      Nakagawa A, Yoshino J, Akata T, et al.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.)

      Pages : 288-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Age-related changes in volatile anesthetic actions on contractile response to norepinephrine in systemic resistance arteries.2004

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.)

      Pages : 288-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 摘出高齢ラット腸間膜小動脈におけるノルエピネフリン収縮反応に対するイソフルランとセボフルランの作用2004

    • Author(s)
      吉野 淳, 泉 薫, 赤田 隆, 他
    • Journal Title

      Journal of Anesthesia 18(Suppl)

      Pages : 124-P2C06

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ノルエピネフリン収縮反応に対するエンフルランの作用-摘出ラット腸間膜小動脈における検討-2004

    • Author(s)
      吉野 淳, 泉 薫, 赤田 隆, 他
    • Journal Title

      Journal of Anesthesia 18(Suppl)

      Pages : 124-P2C03

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ノルエピネフリン血管応答に対するハロタンの直接作用とその機序-摘出ラット腸間膜小動脈における検討-2004

    • Author(s)
      泉 薫, 吉野 淳, 赤田 隆, 他
    • Journal Title

      Journal of Anesthesia 18(Suppl)

      Pages : 139-P2M12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 揮発性吸入麻酔薬に対する血管応答性の加齢に伴う変化2004

    • Author(s)
      吉野 淳, 赤田 隆, 高橋成輔
    • Journal Title

      日本臨床麻酔学会誌 24(8)

      Pages : S61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] 未治療高血圧存在下のセボフルランに対する血管応答性2004

    • Author(s)
      吉野 淳, 赤田 隆, 高橋成輔
    • Journal Title

      日本臨床麻酔学会誌 24(8)

      Pages : S62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Reliability of fingertip skin-surface temperature and its related thermal measures as indices of peripheral perfusion in the clinical setting of the operating theatre.2004

    • Author(s)
      Akata T, Kanna T, Yoshino J, Higashi M, Fukui K, Takahashi S.
    • Journal Title

      Anaesthesia and Intensive Care 32(4)

      Pages : 519-529

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Effects of sevoflurane on contractile response to norepinephrine in systemic resistance arteries isolated from hypertensive rats.2004

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.):289(109)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of etomidate on contractile response to norepinephrine in isolated systemic resistance arteries.2004

    • Author(s)
      Nakagawa A, Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.):288(107)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Age-related changes in volatile anesthetic actions on contractile response to norepinephrine in systemic resistance arteries.2004

    • Author(s)
      Yoshino J, Akata T, Takahashi S
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl.):288(108)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of sevoflurane on contractile response to norepinephrine in systemic resistance arteries isolated from hypertensive rats.2004

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl)

      Pages : 289

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of etomidate on contractile response to norepinephrine in isolated systemic resistance arteries.2004

    • Author(s)
      Nakagawa A, Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl)

      Pages : 288

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Age-related changes in volatile anesthetic actions on contractile response to norepinephrine in systemic resistance arteries.2004

    • Author(s)
      Yoshino J, Akata T, Takahashi S.
    • Journal Title

      Cardiovascular Anesthesia 8(Suppl)

      Pages : 288

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct actions of three volatile anesthetics on vascular smooth muscle activity in mesenteric resistance arteries.2003

    • Author(s)
      Akata T, Izumi K, et al.
    • Journal Title

      Anesthesiology 99

      Pages : A-676

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle in mesenteric resistance arteries.2003

    • Author(s)
      Akata T, Kanna T, et al.
    • Journal Title

      Anesthesiology 99

      Pages : A-747

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of endothelium in the action of halothane on vascular smooth muscle of isolated mesenteric resistance arteries.2003

    • Author(s)
      Yoshino J, Izumi K, Akata T, et al.
    • Journal Title

      Anesthesiology 99

      Pages : A-716

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct action of halothane on rat mesenteric arteries.2003

    • Author(s)
      Yoshino J, Izumi K, Akata T, et al.
    • Journal Title

      Journal of Pharmacological Sciences 91(suppl. I)

      Pages : 265P-3P27

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane vascular smooth muscle of rat small mesenteric arteries2003

    • Author(s)
      Akata T, Kanna T, et al.
    • Journal Title

      Journal of Pharmacological Sciences 91(suppl. I)

      Pages : 265P-3P276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 摘出腸間膜動脈に対するイソフルランの直接抑制作用とその機序 -第2報-2003

    • Author(s)
      赤田 隆, 漢那朝雄, 吉野 淳, 他
    • Journal Title

      Journal of Anesthesia 17(Suppl)

      Pages : 250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ハロタンの内皮依存性ノルエピネフリン収縮反応増強作用の機序-摘出ラット腸間膜小動脈における検討-2003

    • Author(s)
      吉野 淳, 泉 薫, 赤田 隆, 他
    • Journal Title

      Journal of Anesthesia 17(Suppl)

      Pages : 252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 麻酔薬の血管平滑筋への直接作用-その機序-2003

    • Author(s)
      赤田 隆
    • Journal Title

      Journal of Anesthesia 17(Suppl)

      Pages : 252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct actions of three volatile anesthetics on vascular smooth muscle activity in mesenteric resistance arteries.2003

    • Author(s)
      Akata T, Izumi K, Yoshino J, Kanna T, Takahashi S.
    • Journal Title

      Anesthesiology 99:A-676

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle in mesenteric resistance arteries.2003

    • Author(s)
      Akata T, Kanna T, Yoshino J, Takahashi S
    • Journal Title

      Anesthesiology 99:A-747

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of endothelium in the action of halothane on vascular smooth muscle of isolated mesenteric resistance arteries.2003

    • Author(s)
      Yoshino J, Izumi K, Akata T, Takahashi S
    • Journal Title

      Anesthesiology 99:A-716

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Direct action of halothane on rat mesenteric arteries.2003

    • Author(s)
      Yoshino J, Izumi K, Akata T, Takahashi S
    • Journal Title

      Journal of Pharmacological Sciences 91(Suppl.I):265P-3P275

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane vascular smooth muscle of rat small mesenteric arteries.2003

    • Author(s)
      Akata T, Kanna T, Yoshino J, Takahashi S
    • Journal Title

      Journal of Pharmacological Sciences 91(Suppl.I):265P-3P276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sevoflurane and bradykinin-induced calcium mobilization in pulmonary arterial valvular endothelial cells in situ.2002

    • Author(s)
      Kanna T, Akata T, et al.
    • Journal Title

      Journal of Cardiovascular Pharmacology 40(5)

      Pages : 714-724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle of mesenteric resistance arteries.2002

    • Author(s)
      Akata T, Kanna T, et al.
    • Journal Title

      Anesthesiology 99(3)

      Pages : 666-677

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 摘出腸間膜動脈に対するイソフルランの直接抑制作用とその機序2002

    • Author(s)
      赤田 隆, 漢那朝雄, 高橋成輔
    • Journal Title

      Journal of Anesthesia 16(Suppl)

      Pages : 177

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 消化管抵抗血管トーヌス制御機構と揮発性吸入麻酔薬2002

    • Author(s)
      泉 薫, 赤田 隆, 高橋 成輔
    • Journal Title

      Journal of Anesthesia 16(Suppl)

      Pages : 107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Sevoflurane and bradykinin-induced calcium mobilization in pulmonary arterial valvular endothelial cells in situ.2002

    • Author(s)
      Kanna T, Akata T, Izumi K, et al.
    • Journal Title

      Journal of Cardiovascular Pharmacology 40(5)

      Pages : 714-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle of mesenteric resistance arteries.2002

    • Author(s)
      Akata T, Kanna T, Yoshino J, Takahashi S
    • Journal Title

      Anesthesiology 99(3)

      Pages : 666-677

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of volatile anesthestic actions on intracellular Calcium stores of vascular smooth muscle.2001

    • Author(s)
      Akata T, Nakashima M, Izumi K
    • Journal Title

      Anesthesiology 94(5)

      Pages : 840-850

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries.2001

    • Author(s)
      Akata T, Izumi K, Nakashima M
    • Journal Title

      Anesthesiology 95(2)

      Pages : 452-462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Role of endothelium in the action of isoflurane on vascular smooth muscle of isolated mesenteric resistance arteries.2001

    • Author(s)
      Izumi K, Akata T, Takahashi S
    • Journal Title

      Anesthesiology 95(4)

      Pages : 990-998

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 内臓抵抗血管に対するケタミンの直接作用とその機序2001

    • Author(s)
      赤田 隆, 泉 薫, 中島幹夫
    • Journal Title

      Journal of Anesthesia 15(Suppl)

      Pages : 21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 内臓抵抗血管においてノルエピネフリン収縮反応に及ぼすハロタンの効果2001

    • Author(s)
      泉 薫, 赤田 隆, 高橋成輔
    • Journal Title

      Journal of Anesthesia 15(Suppl)

      Pages : 24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparison of volatile anesthestic actions on intracellular calcium stores of vascular smooth muscle.2001

    • Author(s)
      Akata T, Nakashima M, Izumi K
    • Journal Title

      Anesthesiology 94(5)

      Pages : 840-850

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple actions of halothane on contractile response to noradrenaline in isolated mesenteric resistance arteries.

    • Author(s)
      Yoshino J, Akata T, Izumi K, Takahashi S.
    • Journal Title

      Naunyn-Schmiedeberg's Archives of Pharmacology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multiple actions of halothane on contractile response to noradrenaline in isolated mesenteric resistance arteries.

    • Author(s)
      Yoshino J, Akata T, Izumi K, Takahashi S.
    • Journal Title

      Naunyn-Schmiedeberg's Archives of Pharmacology (in press)

    • Related Report
      2004 Annual Research Report
  • [Book] Vascular Reactivity.In Anesthesic Pharmacology (edited by Alex S.Evers and Mervyn Maze)2004

    • Author(s)
      Tsuneyoshi I, Akata T, Boyle WA III
    • Total Pages
      297-321
    • Publisher
      Harcourt, Inc., Orlando, U.S.A.
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle of mesenteric resistance arteries."Anesthesiology. 99・3. 666-677 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane vascular smooth muscle of rat small mesenteric arteries."Journal of Pharmacological Sciences. 91・Suppl. 265 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S: "Direct action of halothane on rat mesenteric arteries."Journal of Pharmacological Science. 91・Suppl. 265 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane on isolated resistance arteries.-2^<nd> report-"Journal of Anesthesia. 17・Suppl. 250 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S: "Mechanisms of the endothelium-dependent enhancing action of halothane on contractile response to norepinephrine."Journal of Anesthesia. 17・Suppl. 252 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akata T, Izumi K, Yoshino J, Kanna T, Takahashi S: "Direct actions of three volatile anesthetics on vascular smooth muscle activity in mesenteric resistance arteries."Anesthesiology(Abstracts of Scientific Papers,2003 Annual Meeting). CD. A-676 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane on vascular smooth muscle in mesenteric resistance arteries."Anesthesiology(Abstracts of Scientific Papers,2003 Annual Meeting). CD. A-747 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S: "Role of endothelium in the action of halothane on vascular smooth muscle of isolated mesenteric resistance arteries."Anesthesiology(Abstracts of Scientific Papers,2003 Annual Meeting). CD. A-716 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Izumi K, Yoshino J, Akata T, Takahashi S: "Mechanisms of direct action of halothane on vascular response to norepinephrine in isolated rat mesenteric arteries."Journal of Anesthesia. 18・Suppl(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S: "Effects of isoflurane and sevoflurane on contractile response to norepinephrine in small mesenteric arteries isolated from aged rats."Journal of Anesthesia. 18・Suppl(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S.: "Effects of enflurane on contractile response to norepinephrine in isolated rat mesenteric resistance arteries."Journal of Anesthesia. 18・Suppl(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tsuneyoshi I, Akata T, Boyle WA III: "Anesthesic Pharmacology(edited by Alex S.Evers and Mervyn Maze)"Vascular reactivity. 297-321 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanna T, Akata T, Izumi K et al.: "Sevoflurane and bradykinin-induced calcium mobilization in pulmonary arterial valvular endothelial cells in situ"Journal of Cardiovascular Pharmacology. 40・5. 714-724 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akata T, Kanna T, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane on isolated resistance arteries"Journal of Anesthesia. 16・Suppl. 177 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S.: "Direct action of halothane on rat mesenteric arteries"Japanese Journal of Pharmacology. 91・Suppl(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane vascular smooth muscle of rat small mesenteric arteries"Japanese Journal of Pharmacology. 91・Suppl(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yoshino J, Izumi K, Akata T, Takahashi S.: "Mechanisms of the endothelium-dependent enhancing action of halothane on contractile response to norepinephrine"Journal of Anesthesia. 17・Suppl(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akata T, Kanna T, Yoshino J, Takahashi S: "Mechanisms of direct inhibitory action of isoflurane on isolated resistance arteries. -2^<nd> report-"Journal of Anesthesia. 17・Suppl(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Akata T, Nakashima M, Izumi K: "Comparison of volatile anesthestic actions on intracellular calcium stores of vascular smooth muscle -Investigation in isolated systemic resistance arteries-"Anesthesiology. 94・5. 840-850 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akata T, Izumi K, Nakashima M: "Mechanisms of direct inhibitory action of ketamine on vascular smooth muscle in mesenteric resistance arteries"Anesthesiology. 95・2. 452-462 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Izumi K, Akata T, Takahashi S: "Role of endothelium in the action of isoflurane on vascular smooth muscle of isolated mesenteric resistance arteries"Anesthesiology. 95・4. 990-998 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 赤田 隆, 泉 薫, 中島幹夫: "内蔵抵抗血管に対するケタミンの直接作用とその機序"Journal of Anesthesia. 15・Suppl. 21 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 泉 薫, 赤田 隆, 高橋成輔: "摘出内蔵抵抗血管においてノルエピネフリン収縮反応を及ぼすハロタンの効果"Journal of Anesthesia. 15・Suppl. 24 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 赤田 隆, 漢那朝雄, 高橋成輔: "摘出腸管膜動脈に対するイソフルランの直接抑制作用とその機序"Journal f Anesthesia. (印刷中). (2002)

    • Related Report
      2001 Annual Research Report

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Published : 2001-04-01   Modified : 2016-04-21  

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