| Project/Area Number |
13671621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TAKAHIRA Takahira Kansai Medical University, Faculty of Medicine, Instructor, 医学部, 助手 (70174901)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Shinichi Kansai Medical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (10207714)
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| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Chronic cerebral hypoperfusion / White matter lesion / Hypocapnia / Caudoputamen / Ketamine / NMDA受容体拮抗薬 / 慢性脳低灌流ラット / caudoputamen / ハロタン / イソフルラン / 脳慢性低灌流ラット / 術後譫妄 |
|---|
| Research Abstract |
White matter lesions are characteristic in a rat model of chronic cerebral hypoperfusion, which is a good model for patients with cerebrovascular diseases. Hypocapnia, induced by hyperventilation, caused specific further neuronal damage in the caudoputamen, which was ameliorated by ketamine pre-administration. These results suggest that hypocapnia during anesthesia may cause tissue damage in the caudoputamen, which may be responsible for long-lasting postoperative delirium and/or memory disturbances in patients with stroke and/or cerebrovascular dementia, and ketamine seems to be useful for preventing the damage.
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