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Study of Lower Urinary Tract Dysfunction According to Aging Using Senescence Accelerated Mouse (SAM)

Research Project

Project/Area Number 13671642
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionShinshu University

Principal Investigator

SATOH Tomoya  Shinahu University, School of Medicine, Assistant, 医学部, 助手 (30291272)

Co-Investigator(Kenkyū-buntansha) ISHIZUKA Osamu  Shinshu University, School of Medicine, Assistant Professor, 医学部, 助教授 (20184541)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsAging / Urinary Bladder / Senescence accelerated mouse / SAM / 排尿機能 / 蓄尿機能
Research Abstract

We studied the urodynamic problems according to aging using SAM
Female 1 years old SAM and 2 years old normal mice (without senescence accelerated symptoms from the same strain) were used as aged group, 14 weeks and 1 year-old normal mice were used as control group. Under urethane anesthesia, polyethylene tube connected to pressure transducer and infusion pump inserted into urinary bladder through the dome. Physiological saline was infused 0.02 ml/min and bladder pressure was monitored under single cystometric condition
In control group, there was no difference in any parameters between 14 weeks old and 1 year old normal mice. In 14 weeks old formal mice, parameters for bladder function were following the pressure threshold for micturition reflex was 9.4 cmH2, bladder compliance was 0.018ml/cmH2O, maximum bladder pressure during voiding was 36.9 cmH2O.In aged group, there was no difference between 1 year old SAM and 2 years old normal mice. In 1 years old SAM, parameters for bladder function were following ; the pressure threshold for micturition reflex was 36.3 cmH2O, bladder compliance was 0.007 ml/cmH2O, maximum bladder pressure during voiding was 44.4 cmH2O. The volume threshold was significantly increased and the bladder compliance was significantly decreased from the control group without altering the maximum pressure of bladder contraction. These data suggested that afferent systems from the bladder and the sympathetic nerve systems were injured in aged mice

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 佐藤智哉, 井川靖彦: "加齢と下部尿路機能と形態"腎と透析. 52. 279-282 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤智哉: "尿道と排尿"脳21. 5. 262-266 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomoya Satoh, Yasuhiko Igawa: "Age-related changes of lower urinary tract in human"Jin to Touseki. 52(3). 279-282 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tomoya Satoh: "Urethra and voiding reflex"Nou 21. 5(3). 262-266 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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