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Involvement of microorganism components in the dialysate effluent of peritoneal dialysis patients

Research Project

Project/Area Number 13671668
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionOsaka City University

Principal Investigator

TSUCHIDA Kenji  Osaka City University Graduate School of Medicine, Department of Urology, Associate Professor of Medicine, 大学院・医学研究科, 講師 (90311919)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Keywordsperitoneal dialysis / dialysate effluent / endotoxin / peptideglycan / peritonitis
Research Abstract

The onset of sclerosing encapsulating peritonitis (SEP) is recently causing a problem, making peritonitis as one of the risk factors. In the present study, we determined the microorganism components in the effluent of peritoneal dialysis (PD) patients to investigate its clinical meaning.
The patients who gave informed consent to this research were used as the subjects (total 27 including 17 males and 10 females ; mean age 52.0±1.25 years old). The subjects were classified by the clinical status into 5 stages, that is, introductory, maintenance, mild peritonitis, intractable peritonitis and long-term stages. As the microorganism components, peptideglycan (PG), endotoxin (ET) and β-D-glucan (BG) were determined.
Of total 506 measurements, PG and ET were detected 65 times and 23 times, respectively. As to the 15 patients in the introductory stage, 10 of the 11 patients in which these components were detected contracted peritonitis later on. The 6 patients in the intractable peritonitis stage demonstrated large component volumes and the cases in which causative microorganism was identified demonstrated serious outcome. Of the 4 long-term stage patients, PG was found in the 2 patients whose peritoneal sclerosis was detected by image analysis.
The determination of microorganism components in peritoneal dialysate effluent during the introductory or maintenance stage can predict the onset of peritonitis and can estimate whether peritonitis, if it occurs, remains mild or develops into intractable peritonitis. Furthermore, there is a possibility that the microorganism components are involved in the onset and progress of SEP.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (4 results)

All 2001 Other

All Journal Article (2 results) Publications (2 results)

  • [Journal Article] 腹膜透析排液中の微生物菌体成分に関する検討-第2報-2001

    • Author(s)
      土田健司, 武本佳昭, 仲谷達也, 他
    • Journal Title

      腎と透析 別冊 腹膜透析'01 51

      Pages: 143-148

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Journal Article] Involvement of microorganism components in the dialysate effluent of peritoneal dialysis patients -Part II2001

    • Author(s)
      K.Tsuchida, Y.Takemoto, T.Nakatani, et al.
    • Journal Title

      Kidney and Dialysis 51

      Pages: 143-148

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 土田健司, 武本佳昭, 仲谷達也, 他: "腹膜透析排液中の微生物菌体成分に関する検討-第2報-"腎と透析 別冊 腹膜透析 '00. 47. 257-261 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 土田健司, 武本佳昭, 仲谷達也 他: "腹膜透析排液中の微生物菌体成分に関する検討-第2報-"腎と透析 別冊 腹膜透析 '00. 47. 257-261 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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