Involvement of microorganism components in the dialysate effluent of peritoneal dialysis patients
| Project/Area Number |
13671668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka City University |
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Principal Investigator |
TSUCHIDA Kenji Osaka City University Graduate School of Medicine, Department of Urology, Associate Professor of Medicine, 大学院・医学研究科, 講師 (90311919)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | peritoneal dialysis / dialysate effluent / endotoxin / peptideglycan / peritonitis |
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| Research Abstract |
The onset of sclerosing encapsulating peritonitis (SEP) is recently causing a problem, making peritonitis as one of the risk factors. In the present study, we determined the microorganism components in the effluent of peritoneal dialysis (PD) patients to investigate its clinical meaning.
The patients who gave informed consent to this research were used as the subjects (total 27 including 17 males and 10 females ; mean age 52.0±1.25 years old). The subjects were classified by the clinical status into 5 stages, that is, introductory, maintenance, mild peritonitis, intractable peritonitis and long-term stages. As the microorganism components, peptideglycan (PG), endotoxin (ET) and β-D-glucan (BG) were determined.
Of total 506 measurements, PG and ET were detected 65 times and 23 times, respectively. As to the 15 patients in the introductory stage, 10 of the 11 patients in which these components were detected contracted peritonitis later on. The 6 patients in the intractable peritonitis stage demonstrated large component volumes and the cases in which causative microorganism was identified demonstrated serious outcome. Of the 4 long-term stage patients, PG was found in the 2 patients whose peritoneal sclerosis was detected by image analysis.
The determination of microorganism components in peritoneal dialysate effluent during the introductory or maintenance stage can predict the onset of peritonitis and can estimate whether peritonitis, if it occurs, remains mild or develops into intractable peritonitis. Furthermore, there is a possibility that the microorganism components are involved in the onset and progress of SEP.
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Report
(3 results)
Research Products
(4 results)
