| Project/Area Number |
13671741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical School |
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Principal Investigator |
SUZUKI Masami Saitama Medical School, Faculty of Medicine, Associate professor, 医学部, 助教授 (50049847)
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| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Nobuko Saitama Medical School, Faculty of Medicine, Assistant, 医学部, 助手 (00322412)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | endometrial cancer / extracted RNA / DNA chip method / estrogen induced gene / エストロゲン依存症 / エストロゲン誘導体遺伝子 / 子官内膜癌 / 子宮内膜細胞増殖因子 / DNAchip法 / efp下流遺伝子の単離 |
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| Research Abstract |
Estrogen may play an important role also in functional regulation of bone metabolism besides cardiovascular system and central nervous system. Furthermore, estrogen having broad physiological function which in multiplication and canceration of mammary gland or endometrium for estrogen target organ is also well known. However these details are unknown. Endometrium easily influenced one of organ with estrogen. Estrogen is a risk-factor of playing the role central as breast cancer, endometrial cancer and endometrial hyperplasia. For clinical use studies, an estrogen supplement treatment positively performed for the prevention and the medical treatment purpose of osteoporosis or ischemic heart disease which are known as climacteric disturbance after a menopause. This research solved the mechanism related to cell multiplication and canceration of estrogen on the moleculer levels. The new estrogen induced gene was isolated from extracted RNA and searched for the endometrium growth factor.
The rate of discovery of the oncogene in endometrial cancer was lowered and that relation with a new estrogen induced gene was not made clearly. Considering this experiment result, the method of isolated a new gene from RNA extracted using the DNA chip method rather than isolation of the gene by classical handmade method is efficient, and the analysis method by which sufficient result is expected is seemed.
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