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Biochemical and molecular biological study on FSH signal transduction in granulosa cell

Research Project

Project/Area Number 13671749
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTOKYOU DENTAL COLLEGE

Principal Investigator

TANABE Kyoo  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY,PROFESSOR, 歯学部, 教授 (10101916)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsguanulos a cell / c-fos / jun-B / PKA / PKC / MARK / 卵胞発育 / シグナル伝達 / FSH / jun B
Research Abstract

The expressions of mRNA of c-fos and jun-B were significantly increased byaddition of FSH in granulosa cell. These phenomena were also observed by addition of PMA in dose dependent manner. The action of FSH was suppressed by staurosporine, but not by Rp-CAMP. MAPK activity in granulosa cell was increased in the presence of FSH. The addition of PMA induced the activityofMAPK activity, whereas forskolin and 8Br-CAMP gave no significant influences.The activation of MAPK in the presence of FSH was significantly suppressed by coexistence of staurosporine.
The above results suggested the possibility that the influences of FSH might beappeared by the expression of mRNA of c-fos and jun-B, and the signaltransductionadvanced through PKC pathway, but not through PKA pathway. Furthermore,MAPK was also activated by FSH and its singal transduction also might path through PKC system.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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