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Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses

Research Project

Project/Area Number 13671828
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

USUI Tomoaki  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (90303122)

Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsElectroretinogram(ERG) / Retinal function / Retinitis pigmentosa / Retinoschisis / Oguchi disease / Gene analysis / 錐体ジストロフィー / 網膜中心静脈閉塞症
Research Abstract

The study, entitled "Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses", tried to analyze retinal function in normal controls and patients with various ophthalmological diseases using rod and cone a-wave(P3) models, derived P2 model, and ON/OFF ERG responses to long flash stimulation.
At first we recorded conventional(scotopic and photopic) ERGs and ON/OFF responses to 200 msec flash stimulation in 30 normal volunteers, and measured the normal values of amplitudes and peak latencies from the wave components (a-,b-,d-, OP-waves, and so on). After that, we calculated the parameters(Rm,S,td,etc) of the P3-and derived P2-models in normal controls. The values from various patients with ophthalmological disease(ex.retinitis pigmentosa, cone dystrophy, congenital retinoschisis, Oguchi disease, vitamin A deficiency, central retinal vein occlusion) were compared with those from normal controls. Other results of ophthalmological examinations, including visual acuity, visual field, ocular Hindus, dark adaptation curves, gene analysis, were also analyzed in the patients.
It would be beneficial for patients to see the precise retinal function objectively from several examinations. New ERG methods to estimate retinal function shown in this study would be used in gene therapy and retinal transplantation in retinal degeneration in the near future.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Usui T: "Rod and cone a-waves in three cases of Bietti crystalline chorioretinal dystrophy"American Journal of Ophthalmology. 132. 395-402 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayakawa Y: "Cross-axis adaptation of pursuit initiation in humans"Investigative Ophthalmology and Visual Science. 42. 668-674 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi M: "Adaptive changes in dynamic properties of human disparity-induced vergence"Investigative Ophthalmology and Visual Science. 42. 1479-1486 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogawa R: "Bilateral optic disc drusen with severe progressive visual field defect"Neuro-ophthalmology. 20. 229-232 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki K: "Multifocal electroretinogram in patients with central serous chorioretinopathy"Japanese Journal of Ophthalmology. 46. 308-314 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ando T: "Pupillary and cardiovasucular responses to a video movie in senior human subjects"Autonomic Neuroscience : Basic and Clinic. 97. 129-135 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanimoto N: "Electroretinographic findings in three family members with X-linked juvenile retinoschisis associated with a novel Pro192Thr mutation of the XLRS1 gene"Japanese Journal of Ophthalmology. 46. 568-576 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Cone dysfunction with negative electroretinogram and ring scotoma ; a case report"Neuro-ophthalmology. 27. 111-120 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekiya K: "Long-term fundus change of fundus albipunctatus associated with mutations in the RDH5 gene"Archives of Ophthalmology. 121. 1057-1059 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 尾山 徳秀: "Senior-Loken症候群の2例"日本眼科学会雑誌. 108. 29-37 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 池田 純: "網膜静脈閉塞症の多局所網膜電図"日本眼科学会雑誌. 108. 84-91 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Rod a-wave in Oguchi disease"Vision Research. 44. 535-540 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome"Retina. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanimoto N: "Central and peripheral visual interactions in disparity-induced vergence eye movements : I.Spatial interaction"Investigative Ophthalmology and Visual Science. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Rod and cone a-waves in three cases of Bietti crystalline chorioretinal dystrophy."American Journal of Ophthalmology. 132. 395-402 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hayakawa Y: "Cross-axis adaptation of pursuit initiation in humans"Investigative Ophthalmology and Visual Science. 42. 668-674 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takagi M: "Adaptive changes in dynamic properties of human disparity-induced vergence"Investigative Ophthalmology and Visual Science. 42. 1479-1486 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ogawa R: "Bilateral optic disc drusen with severe progressive visual field defect"Neuro-ophthalmology. 20. 229-232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki K: "Multifocal electroretinogram in patients with central serous chorioretinopathy"Japanese Journal of Ophthalmology. 46. 308-314 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ando T: "Pupillary and cardiovasucular responses to a video movie in senior human subjects"Autonomic Neuroscience : Basic and Clinic. 97. 129-135 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanimoto N: "Electroretinographic findings in three family members with X-linked juvenile retinoschisis associated with a novel Pro192thr mutation of the XLRS1 gene"Japanese Journal of Ophthalmology. 46. 568-576 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Cone dysfunction with negative electroretinogram and ring scotoma ; a case report"Neuro-ophthalmology. 27. 111-120 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekiya K: "Long-term fundus change of fundus albipunctatus associated with mutations in the RDH5 gene"Archives of Ophthalmology. 121. 1057-1059 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Oyama T: "Two cases of Senior-Loken syndrome"Journal of Japanese Ophthalmological Society. 108. 29-37 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda J: "Multifocal electroretinograms in patients with retinal vein occlusion"Journal of Japanese Ophthalmological Society. 108. 84-91 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Rod a-wave in Oguchi disease"Vision Research. 44. 535-540 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Usui T: "Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome"Retina. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanimoto N: "Central and peripheral visual interactions in disparity-induced vergence eye movements : I.Spatial interaction"Investigative Ophthalmology and Visual Science. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tomoaki Usui: "Rod a-wave in Oguchi disease"Vision Research. 44. 535-540 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 尾山 徳秀: "Senior-Loken症候群の2例"日本眼科学会雑誌. 108. 29-37 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 池田 純: "網膜静脈閉塞症の多局所網膜電図"日本眼科学会雑誌. 108. 84-91 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Keigo Sekiya: "Long-term fundus change of fundus albipunctatus associated with mutations in the RDH5 gene"Archives of Ophthalmology. 121. 1057-1059 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tomoaki Usui: "Ocular fundus images by scanning laser ophthalmoscopy in a patient with enhanced S-cone syndrome"Retina. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] Naoyuki Tanimoto: "Central and peripheral visual interactions in disparity-induced vergence eye movements : I. Spatial interaction"Visual Science. 印刷中.

    • Related Report
      2003 Annual Research Report
  • [Publications] Usui T: "Cone dysfunction with negative electroretinogram and ring scotoma ; a case report"Neuro-ophthalmology. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki K: "Multifocal electroretinogram in central serous chorioretonopathy"Japanese Journal of Ophthalmology. 46. 308-314 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanimoto N: "Electroretinographic findings in three family members with X-linked juvenile retinoschisis associated with a novel Pro192Thr mutation of the XLRS1 gene"Japanese Journal of Ophthalmology. 46. 568-576 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ando T: "Pupillary and cardiovasucular responses to a video movie in senior human subjects"Autonomic Neuroscience : Bacsic and Clinic. 97. 129-135 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tanimoto N: "Electroretinographic findings in three family members with X-linked juvenile retinoschisis associated with a novel Pro192Thr mutation of the XLRS1 gene"Japanese Journal of Ophthalmology. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki K: "Multifocal electroretinogram in central serous chorioretonopathy"Japanese Journal of Ophthalmology. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui T: "Rod and cone a-waves in three cases of Bietti's crystalline chorioretinal dystrophy"American Journal of Ophthalmology. 132. 395-402 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takagi M: "Adaptive changes in dynamic properties of human disparity-induced vergence"Investigative Ophthalmology and Visual Science. 42. 1479-1486 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui T: "Rod a-wave in Oguchi disease"Investigative Ophthalmology and Visual Science. 42. S73 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hasegawa S: "Topographic mapping of contrast sensitivity by multifocal visual-evoked potentials"Investigative Ophthalmology and Visual Science. 42. S790 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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