STUDY ON PROKIFERATIVE DIABETIC RETINOPATHY OF DIABTIC RAT(WBN/Kob)

• Project/Area Number: 13671860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: SETSUNAN UNIVERCITY
• Principal Investigator: MATSUURA Tetsuro SETSUNAN UNIVERCITY, FACULTY OF PHARMACEUTICAL SCIENCES, ASSISTANT PROFESSOR, 薬学部, 講師 (20268494)
• Co-Investigator(Kenkyū-buntansha): OZAKI Kiyokazu SETSUNAN UNIVERCITY, FACULTY OF PHARMACEUTICAL SCIENCES, ASSISTANT PROFESSOR, 薬学部, 助手 (40268496) ; NARAMA Isao SETSUNAN UNIVERCITY, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (80268490)
• Project Period (FY): 2001 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥1,500,000 (Direct Cost: ¥1,500,000); Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: Retinopathy / Diabetic retinopathy / Neovascularization / WBN / Kob / Rat

Research Abstract

We investigate the histopathological changes of the fundus in aged male rats of WBN/Kob strain to ascertain whether proliferative diabetic retinopathy is induced or not. Severe hyperglycemia and glucosuria lasted from 10 months to 24 months of age in male rats. In male rats, the vitreous body was partially or entirely filled with fibrous tissue corresponding to the grossly white mass on both sides. The newly formed vessels remarkably increased within the fibrous tissue in the vitreous body. In non-diabetic females, these changes were not seen. WBN/Kob rats are likely to be one of the diabetic animal models for progressive diabetic retinopathy and may provide further informations to cause of retinal angiogenesis.

Research Products

• [Publications] T Matsuura, K.Ozaki, Y Kodama, Y.Kondo, I.Narama: "Proliferative changes in the fundus of diabetic rats (WBN/Kob)"Folia Opthalmologica Japanica. 54・3. 168-171 (2003)
• [Publications] Terai, T., Osakabe, K., Katai, M., Sakaguchi, K., Narama, I., Matsuura, T., Katakawa, J., Tetsumi, T.: "Preparation of 9-hydroxy grayanotoxin derivatives and their acute toxicity in mice"Chem Pharm Bull (Tokyo). 51. 351-353 (2003)
• [Publications] Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: "A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology"Toxicol Pathol. 16. 1-17 (2003)
• [Publications] Ozaki, K., Yamagami, T., Haritani, Y., Tsutsumi, Y., Narama, I.: "Abscess-forming inflammatory granulation tissue with gram-positive cocci and prominent eosinophil infiltration in cats : possible infection of methicillin-resistant stapylococcus"Vet pathol. 40. 283-287 (2003)
• [Publications] K.Ozaki, T.Matsuura, I, Narama: "Histochemical and morphological analysis of skeletal muscle in spontaneous diabetic WBN/Kob rat"Acta Neuropathol. 102. 264-270 (2001)
• [Publications] 松浦哲郎, 前野亜紀子, 尾崎清和, 奈良間功: "WBN/Kobラットの網膜および硝子体に認められた増殖性変化"Diabetes Frontier. 12. 806-807 (2001)
• [Publications] K.Ozaki, T.Matsuura, I, Narama: "Histochemical and morphological analysis of skeletal muscle in spontaneous diabetic WBN/Kob rat"Acta Neuropathol. 102. 264-271 (2001)
• [Publications] 松浦哲郎, 前野亜紀子, 尾崎清和, 奈良間功: "WBN/Kobラットの網膜および硝子体に認められた増殖性変化"Diabetes Frontier. 12. 806-807 (2001)
• [Publications] 尾崎清和, 松浦哲郎, 奈良間功: "Histochemical and morphological analysis of skeletal muscle in spontaneous diabetic WBN/Kob rat"Diabetes Frontier. 12. 809-809 (2001)
• [Publications] T Matsuura, K.Ozaki, Y Kodama, Y.Kondo, I.Narama: "Proliferative changes in the fundus of diabetic rats (WBN/Kob)"Folia Opthalmologica Japonica. 54・3. (2003)