| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
In the present study the effects of bisphenol A (BPA) on tooth development of Wistar rat offspring were observed after pregnant rats were administered orally with doses of 10, 100, 500 and 750mg/kg body weight (b.w.)/day in gestation days from 13 to 19. The weight of whole body and testis (including epididymis) were measured in 13-day-old offsprings. Their lower right first molars were scanned by cone-beam type micro focus x-ray computed tomography system. And then, the volume of them was calculated by 3D reconstruction image analysis software. However, the offsprings of 750mg/kg b.w./day were born dead. The testis weight of sham group was significantly than both 100mg/kg b.w./day and 500mg/kg b.w./day groups. In all groups, the mean body weights of male offsprings were heavier than those of female ones. The higher dose group showed the less sex difference of body weight. In the male offsprings, the higher dose group showed the less body weight. In the female offspring, however, 10mg/k
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g b.w./day group was heaviest and followed by sham, 500 and 100mg/kg b.w./day group. In all groups, the volume of the lower first molar of female offsprings averaged higher than those of male offsprings. In the male offsprings, sham group showed the highest average of molar volume and was followed by 10,500 and 100mg/kg b.w./day groups. In the female offspring, however, the higher dose group showed the less volume of the molar. The effects of the dose of BPA and sex difference for the body weight or the molar volume were investigated by the two-way ANOVA. The dose of BPA and sex difference showed statistically significant effects for either body weight or the molar volume. However, interaction of the dose of BPA and sex difference was not observed. The Turkey's Least Significant Difference observed the statistically significant difference in the body weight observed only between 10mg/kg b.w./day group and 100mg/kg b.w./day group. On the other hand, the statistically significant differences in the molar volume were observed between sham group and all other groups. Less
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