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Leaching behavior and the estrogenic activity of phthalate monoesters

Research Project

Project/Area Number 13672071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionFukuoka Dental College

Principal Investigator

KAWAGUCHI Minoru  Fukuoka Dental College, Faculty of Dentistry, Research Assistant, 歯学部, 助手 (10122780)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Yutaka  Fukuoka Dental College, Faculty of Dentistry, Professor, 歯学部, 教授 (50154878)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsdental soft polymer / phthalate ester / leaching / estrogenicity / human saliva / hydrolysis / 歯科用軟性裏装材 / 内分泌攪乱作用 / 唾液 / 可塑剤 / ティッシュコンディショナー / 内分泌撹乱作用 / 環境ホルモン
Research Abstract

The commercially-available dental soft polymers contain various types of phthalate esters as plasticizer. Phthalate esters reportedly have estrogenic activity. The purpose of this study was to investigate the leaching behavior of phthalate esters from dental soft polymers under various immersing mediums. The phthalate esters showed continuous leaching for 14-days immersion. The amount of leached phthalate esters from the soft polymers immersed in ethanol solution was greater than that immersed in distilled water. The similar leaching behavior was observed for the experimental soft polymers (based on three types of phthalate esters). Additional experiment was carried out for the experimental soft polymers under immersed in human saliva to examine the leaching behavior under intra-oral conditions. The leaching of phthalate esters immersed in human saliva showed a different pattern from immersed in distilled water. The experimental soft polymers leached less amount phthalate esters when immersed in human saliva than those immersed in water. This findings would be due to the hydrolysis of phthalate esters by various enzymes in human saliva.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 川口 稔: "ティッシュコンディショナーからの可塑剤成分の溶出性"日本補綴歯科学会雑誌. 45. 504-511 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiya Hashimoto: "asurement of estrogenic activity of chemicals for the development of new dental polym"Toxivology in Vitro. 15. 421-425 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiya Hashimoto: "Estrogenic activity of tissue conditioners in vitro"Dental Materials. 19. 341-346 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Minoru Kawaguchi: "Leaching of plasticizers from tissue conditioners"J Jpn Prosthodont Soc. vol. 45. 504-511 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiya Hashimoto: "Measurement of estrogenic activity of chemicals for the development of new dental polymers"Toxicology in Vitro. vol. 15. 421-425 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiya Hashimoto: "Estrogenic activity of tissue conditioners in vitro"Dental Materials. vol. 19. 341-346 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 川口 稔: "ティッシュコンディショナーからの可塑剤成分の溶出性"日本補綴歯科学会雑誌. 45・4. 504-511 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y.Hashimoto: "Measurement of estrogenic activity of chemicals for the development of new dental polymers"Toxicology in Vitro. 15・4. 421-425 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] 川口稔, 他5名: "ティッシュコンディショナーからの可塑剤成分の溶出性"日本補綴歯科学会雑誌. 45巻4号. 504-511 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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